Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Circulating tumor cell"”.
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Apoptotic cells promote circulating tumor cell survival and metastasis
During tumor progression and especially following cytotoxic therapy, cell death of both tumor and stromal cells is widespread. Despite clinical observations that high levels of apoptotic cells correlate with poorer patient outcomes, the physiological effects of dying cells on tumor progression …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …
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An optofluidic platform for longitudinal circulating tumor cell studies in mouse models of cancer
… for over 90% of cancer-related deaths. Circulating tumor cells (CTCs) that are shed from primary tumors represent the disseminating "seeds" that give rise to distant malignant growths. Despite their importance to metastasis, understanding of their role has been hindered by the extreme …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… reprogramming is considered a major factor in cellular transformation and tumor initiation, but whether or how metabolism supports tumor metastasis remains an open question. This study seeks to identify metabolic predictors of metastasis, with the rationale that understanding metabolic changes …
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A blood exchange method to study circulation kinetics of tumor cells in the blood
Blood is an essential compartment for tumor cell trafficking. In solid epithelial-derived tumors, blood serves as the major vehicle for metastasis, whose principal cell is the circulating tumor cell (CTC). These cells originate from the primary tumor and are shed at low concentrations into the …
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Development of High-speed Photoacoustic Imaging technology and Its Applications in Biomedical Research
… spectrum. For example, hemoglobin in red blood cells is of particular interest in PAT since it is one of the dominant absorbers in tissue at the visible wavelength.The main focus of this dissertation is to develop high-speed PA microscopy (PAM) technologies. Novel optical scanning, ultrasonic …
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Measurement of Tumor Extent and Effects of Breast Compression in Digital Mammography and Breast Tomosynthesis
… the detrimental effect of the projected anatomy. Tumor size is an important predictor of prognosis and treatment effect. We hypothesized that the tumor outline would be better defined in BT and therefore tumor measurement in BT would be more accurate compared with DM. The results showed that …
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Microfluidic Technology for Low-Input Epigenomic Analysis
… and regulation, and are highly involved in cellular processes such as stem cell pluripotency/differentiation and tumorigenesis. Chromatin immunoprecipitation (ChIP) is the technique of choice for examining in vivo DNA-protein interactions and has been a great tool for studying epigenetic …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… how AC shapes clonal evolution from primary tumors (PT) to metastatic sites, and establishes a platform to recover and characterize metastasis‐derived circulating tumor cells (CTCs), with the goal of revealing actionable vulnerabilities. I adapted a human TNBC (MDA‐MB‐231) xenograft to a …