Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Circulating cell-free DNA"”.
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Investigating the role of circulating cell-free dna as a mechanistic biomarker in inflammatory bowel disease: development of an integrated precision-medicine enabled platform in Scotland
BACKGROUND: Circulating cell-free DNA (cfDNA) represents a class of biological molecules whose role in inflammation remains poorly understood. Inflammatory bowel disease (IBD), from ulcerative colitis to Crohn’s disease, comprises a spectrum of chronic immune-mediated conditions with complex …
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A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
… it can spread throughout the body. Evaluation of circulating cell-free DNA (cfDNA), specifically, detection of circulating tumor DNA (ctDNA), is being explored as an approach for non-invasive ‘liquid biopsy’ that can be deployed widely and cost-effectively to screen for early signs of disease. DNA …
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Modular CRISPR-diagnostics for Infectious Diseases
… by applying it to the detection of plasma circulating cell-free DNA in tuberculosis, highlighting its potential as a liquid biopsy test for infectious disease management.
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… into the potential utility of these circulating biomarkers as analytic test measures complementing radiological imaging have been occasioned by the invasive nature of malignant tumour tissue biopsy, the need for serial evaluation of tumour burden during therapy, and the need for …
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… to serial sampling. Liquid biopsies contain circulating cell free DNA (cfDNA) released from widespread tumor cells, potentially uncovering the full tumor landscape. By using next generation sequencing on cfDNA obtained from plasma, I developed strategies aimed at systematically tracking the …
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Investigating the Mechanisms and Kinetics of Circulating Tumour DNA Release to Improve its Clinical Utility
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with distinct subtypes, molecular features and clinical behaviours. Significant advances to better define this heterogeneity have revealed new targets and attempted to stratify patients into clinically meaningful groups. Human …