Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Circulating Tumor Cells"”.
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Technologies for the isolation of circulating tumor cells
Metastasis, the spread and growth of tumor cells from the primary site to distant organs, is arguably the most devastating and deadly attribute of cancer, and is ultimately responsible for 90% of cancer-related deaths. Circulating tumor cells (CTCs) are exceedingly rare cells found in the whole …
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Selective Isolation of Circulating Tumor Cells in Antibody-Functionalized Microsystems
Attachment of circulating tumor cells in microfluidic devices functionalized with proper antibodies was studied. Under static experimental conditions, microchambers were utilized to study the parameters such as cell suspension concentration, incubation time or ambient temperature that may affect …
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Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
Circulating tumor cells (CTCs) represent a unique source of information that might help clarifying numerous aspects of metastasis biology and finding new clinically relevant biomarkers. On the hypothesis that CTCs possess a distinct profile compared to solid primary and secondary lesions, the …
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Context Dependent Roles of MDMX (MDM4) and MDM2 in Breast Cancer Proliferation and Circulating Tumor Cells
… promotes proliferation in ER+ T47D breast cancer cells in a p53-independent manner. Whether MDM2 elicits <em>in vivo</em> p53-independent proliferative functions in T47D breast cancer cells has not been determined. Furthermore it has been shown that ectopic expression of MDM2 targets E-Cadherin …
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Novel approaches to investigate behaviors of bacteria by atomic force microscopy and circulating tumor cells through microfluidics
… and apparent ingenuity of renegade and intruding cells within the human body present formidable challenges in warding off disease. As the longevity of humans increases, cancer will afflict greater numbers, and if bacteria continue to grow resistant to conventional antibiotics, new treatment …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… how AC shapes clonal evolution from primary tumors (PT) to metastatic sites, and establishes a platform to recover and characterize metastasis‐derived circulating tumor cells (CTCs), with the goal of revealing actionable vulnerabilities. I adapted a human TNBC (MDA‐MB‐231) xenograft to a …
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Detecting cells and analyzing their behaviors in microscopy images using deep neural networks
… the power of deep neural network in the Circulating Tumor Cells detection and mitosis event detection. We will introduce the Convolutional Neural Networks and the designed training methodology for Circulating Tumor Cells detection, a Hierarchical Convolutional Neural Networks model and a …
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Zein films as substrates for cell attachment
Circulating tumor cells (CTCs) are cells that have shed into the vasculature from a primary tumor and circulate in the blood stream. Circulating tumor cells play an important role in metastasis. The long term goal of this project is to capture and remocve CTC’s from the blood stream. Numerous …
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Characterization of Photoacoustic Flow Cytometry Signals
… to clinically determine the presence of melanoma circulating tumor cells (CTCs). Further investigation was conducted into the morphology of detection signals and how they could be manipulated to allow for further classification. Novel features were extracted from waveforms that appear to have …
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An optofluidic platform for longitudinal circulating tumor cell studies in mouse models of cancer
… for over 90% of cancer-related deaths. Circulating tumor cells (CTCs) that are shed from primary tumors represent the disseminating "seeds" that give rise to distant malignant growths. Despite their importance to metastasis, understanding of their role has been hindered by the extreme …
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Measurement of Tumor Extent and Effects of Breast Compression in Digital Mammography and Breast Tomosynthesis
… the detrimental effect of the projected anatomy. Tumor size is an important predictor of prognosis and treatment effect. We hypothesized that the tumor outline would be better defined in BT and therefore tumor measurement in BT would be more accurate compared with DM. The results showed that …
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Photoacoustic detection of metastatic melanoma in the human circulatory system
Detection of disseminating tumor cells can function as an early warning system, alerting the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease while late stage detection can serve as an indicator of the effectiveness of …
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Development of High-Throughput Platforms for Single-Cell Analysis
… deal with highly heterogeneous populations of cells where the contributions of individual players cannot be ignored. Single-cell technologies aim to resolve this heterogeneity by analyzing many individual cells in a high-throughput manner. Here we developed two examples of such tools that rely …
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Experimental Validation of Heteroclinic Orbit Dynamics in Inertial Microfluidics
… the goal of improving label-free isolation of circulating tumor cells (CTCs) for liquid biopsy applications. CTCs are extremely rare in blood, making their separation both technically challenging and clinically significant. Inertial microfluidics offers a promising alternative to traditional …
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Genome sequencing and phenotypic analysis of single cells in cancer
… genome profiling (~99%) is done on primary tumors; yet, metastatic cancer is attributed to >90% of cancer-related deaths. The underlying challenge is that metastatic cancer is difficult to sample: surgical resections are less common, metastatic biopsies are not part of clinical routine, and …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
… considered as a late event in the primary tumor process. Recent evidence suggests that tumor cells dissemination may occur when the tumor is at a size that does not normally warrant a systemic treatment. Current breast cancer models developed as part of the Cancer Intervention and …
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Bioengineered surfaces and hydrogels for specific cell capture and release from whole blood
… is no reliable method to release the target cells from the capture surface while preserving their integrity. This work presents the development and evaluation of a functional hydrogel coating that supplements microfluidic capture devices to enable both specific capture and release. The …
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Passivated-Electrode Insulator-Based Dielectrophoretic Chips for Rare Cell Analysis
… One powerful technique for the analysis of cells is the use of dielectrophoresis (DEP) forces for the manipulation of particle movement. DEP is a particle transport phenomenon, induced by the presence of non-uniform electric fields. The dependence on intrinsic electrical properties of cells, …
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Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells
Metastasis is a multistep process during which tumor cells separate from a primary tumor, penetrate the bloodstream, evade host defenses, and colonize distant organs. This final and fatal step in tumor development is the cause of more than 90% of cancer related deaths. Therapies and diagnostics can …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
… and treatment. Recently, liquid biopsy and circulating cancer biomarkers such as circulating tumor cells (CTC), extracellular vesicles (EV), and cell free DNA (cfDNA) have gained great attentions for early diagnosis, prognosis, and treatment monitoring of cancer patients because they can be …
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