Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Circadian disruption"”.
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PHYSIOLOGICAL CONSEQUENCES OF CIRCADIAN DISRUPTION BY NIGHTTIME LIGHT EXPOSURE
… organisms have developed endogenously driven circadian rhythms which are synchronized to this light/dark cycle. In recent years, daily light schedules have become artificial and irregular due to the use of electric lighting. In this dissertation, I propose that exposure to light at night (LAN) …
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Circadian Disruption by Light at Night: Implications for Mood
… has adapted to a consistent 24-h solar cycle. Circadian rhythms in physiology and behavior remain synchronized to the environment using light as the most potent entraining cue. During the past century, however, the widespread adoption of electric light has led to `round-the-clock’ societies. …
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Exploring the epigenetic link in circadian disruption induced breast cancer
… women worldwide. Evidence is also mounting that circadian disruption (CD) is probably carcinogenic to humans and is linked to breast cancer development. The aim of this thesis is to provide new insights into the epigenetic links involved in CD-induced breast cancer. The results presented here …
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Markers of Circadian Disruption and Reproductive Risk Factors for Breast Cancer
Background: Circadian disruption is hypothesized to impact reproductive signaling, which in turn has long been linked to breast cancer. The melatonin hypothesis holds that increased exposure to artificial light at night and resulting inhibition of nocturnal melatonin may account for recent …
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Chronic Circadian Disruption Alters Behaviour, Cardiac Function and Glucose Regulation in Mice
The circadian system regulates many physiological functions including the cardiovascular system, metabolism, and stress response. Accordingly, circadian misalignment in mammals contributes to cardiometabolic disease and stress-induced emotional disorders. The BTBR mouse strain shows several …
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The intersection of pain, disease severity, and circadian disruption in experimental autoimmune encephalomyelitis
… an emerging area of research in the MS field: circadian rhythms, the 24-hour biological rhythms governing a significant number of functions at the behavioural, systems, cellular, and molecular levels. Evidence suggests that people with MS experience disruption in their circadian rhythms, and …
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Circadian disruption causes deficits in attention and response inhibition in adult Long-Evans rats
Circadian rhythms are endogenous rhythms governing behavior and physiology. Circadian disruption is an environmental factor that impacts cognition and increases the risk of neurodegenerative disease by altering the circadian clock at a molecular level. Conventional sources of circadian disruption …
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Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome
… Chronic misalignment of an organism’s internal circadian clock with diurnal, cyclic changes in the external environment, prevalent in professions that require shift work, contributes significantly to Type 2 Diabetes development. Experimentally, only short-term models of circadian disruption have …
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The effect of circadian regulation and sleep disruption on metabolic homeostasis
Sleep and circadian disruption are ubiquitous in modern society. While the National Sleep Foundation recommends adults sleep 7-9 hours per night, the average sleep duration of American adults has decreased from ~8.8 hours to ~6.8 hours over the last century, with 1 in 3 people report sleeping fewer …
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Early Life Circadian Rhythm Disruptions Alters Brain and Behavior in Adulthood
… aim of this study is to investigate sleep and circadian rhythm disruptions during postnatal period on behavior in adulthood using an animal model (C57B/6 mice) where it is possible to disentangle these various confounding factors. In particular, the current study is examining the consequences …
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White Adipose Tissue Remodeling by Intermittent Fasting
… analysis revealed significant enrichment of circadian pathway within the APs, which could be a key mediator of IF-induced WAT remodeling. Interestingly, animal models with circadian disruption exhibited higher WAT mass and pro-fibrotic WAT remodeling, suggesting that circadian disruption is a …
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Distribution of sleep structure is maintained, but adjusted in an acute circadian shift: a study by continuous long-term local field potential recording
Evidence suggests that the disruption of circadian rhythms has a negative impact on memory retention. It is therefore speculated that circadian disruption influences some property of sleep responsible for memory retention, but little is known about this relationship. In order to investigate this …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… in a diurnal fashion as regulated by the master circadian (daily) clock in the suprachiasmatic nuclei ( SCN). Signaling in this regard is at least partially responsible for entraining circadian clocks outside of the SCN. Just as shifts in glucocorticoid exposure are associated with metabolic …
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Estradiol exerts activational and organizational control over the expression of daily and circadian activity rhythms in mice
Robust sex differences in daily and circadian activity rhythms, as well as the manifestation of circadian disruption-associated pathologies, have been reported in numerous species, including humans and laboratory models. These differences are mediated, at least in part, by sexually dichotomous …
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Non-Photic Mechanisms of Entrainment In Bmal1 Deficient Conditions
<p>Maintaining our internal circadian (i.e. 24 -hour) clock is imperative to our daily biological and mental well-being. Large epidemiological studies have shown that disruptions of our circadian rhythms can lead to poor mental health, metabolic diseases, and various types of cancer. Various …
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Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
… that dim-light would interfere with the circadian rhythm of C57Bl/6 mice and induce both depressive-like and anxiety-like behaviours and that there would be sex-specific differences. Animals were either singly or group housed for a three week period where locomotor activity was measured. …
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Impairment in mitochondrial oxidative phosphorylation alters clock gene expression
… disrupt our normal 24- hour internal clock or circadian rhythm. The molecular mechanisms that link chronic circadian disruption to disease are not well understood. Since light exposure at night is known to decrease melatonin levels, some researchers have hypothesized that a reduction in the …
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Circadian modulation of the estrogen receptor alpha transcription
The circadian clock is a molecular mechanism that synchronizes physiological changes with environmental variations. Disruption of the circadian clock has been linked to increased risk in diseases and a number of disorders (e.g. jet lag, insomnia, and cancer). Period 2 (Per2), a circadian protein, …
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Breast Cancer and Cortisol Secretion in Relation to the Per3 Vntr, Chronotype, and Sleep
<p>Background: Circadian rhythm disruption, sleep abnormalities, and shift work have emerged as cancer risk factors. Genetic variation of clock genes, which aid in circadian rhythm control, may increase cancer susceptibility or lead to disruption of hormone secretion. A Period 3 (Per3) clock gene …
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