Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 491 for “"Circadian"”.
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Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome
… Chronic misalignment of an organism’s internal circadian clock with diurnal, cyclic changes in the external environment, prevalent in professions that require shift work, contributes significantly to Type 2 Diabetes development. Experimentally, only short-term models of circadian disruption have …
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Circadian Influences in Cocaine Reinforcement
… has been our belief that there is an endogenous circadian control that underlies (at least in part) self-administration behavior. This control can be over-ridden after extended self-administration and with higher dosing and access parameters. The neurobiological correlates of this control could …
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Exploring circadian blood pressure patterns
… offers a powerful tool in the analysis of circadian patterns and short-term BPV. The main aims of this thesis were to explore and identify circadian BP patterns between individuals and groups, and extract meaningful measures that describe these patterns while appropriately accounting for …
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Metabolic Regulation of Circadian Timekeeping
Circadian rhythms are self-sustained endogenous biological oscillations with a period of approximately 24 hours. These rhythms are observed widely across kingdoms and at all levels of biological scale. Recent work has shown there to be circadian variation in metabolism, both at the organismal and …
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Circadian Regulation of Protein Homeostasis
Circadian rhythms orchestrate physiology across all kingdoms of life to anticipate the differing demands of day and night. Circadian timekeeping has a cell-autonomous basis, amenable to study in cultured mammalian cells, where daily rhythms have been shown to affect most biological processes. In …
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Circadian Rhythm in Intrinsic Heart Rate
… stroke, and sudden cardiac death) show circadian patterns. Circadian HR fluctuations are traditionally thought to be controlled by the autonomic nervous system (ANS). However, recent studies have concluded that diurnal HR variation arise from intrinsic remodeling in SA node. To …
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Adolescent sleep and the circadian pacemaker
… mental development. Adolescents often exhibit a circadian phase delay in which they tend to go to bed later and wake up later compared to adults. This thesis seeks to understand the adolescent phase delay and its relationship to the circadian pacemaker, the body’s master clock. Using a dynamic …
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Circadian Orchestration of the Cellular Proteome
Circadian rhythms are biological oscillations with a period length of roughly 24 hours. They confer an adaptive advantage as they enable the prediction of the regular environmental changes caused by the rotation of the Earth, and so they are highly conserved. Circadian coordination of biology is an …
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Circadian Control of Cell Cycle Progression
Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint …
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Circadian Secretion of Glucagon-like Peptide-1
Circadian rhythms are 24-hour biological rhythms within organisms that have developed over evolutionary time due to pre-defined environmental changes, mainly the light-dark cycle. Interestingly, metabolic tissues, which have been found to express cell-autonomous clocks that are entrained by food …
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Reliability and circadian rhythmicity of blood lactate
The reliability in measurement of, the circadian variation in, and the effects of catecholamine concentration on venous and arterialized lactate during rest and exercise were examined in twelve trained males (26.4 ± 5.4 yrs, 76.7 ± 8.5 kg , 180.5 ± 8.5 cm, and 58.1 ± 4.6 ml-kg⁻¹•min⁻¹). The …
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Architecture of the Mammalian Circadian Repressive Complex
… their physiology to the solar day. Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRY1/2 and PER1/2). To understand what drives periodicity within this clock, I took structural approaches with the …
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The circadian Control of DNA end Resection
… this thesis, we uncovered a novel role for the circadian clock in the regulation of DNA end resection, the licensing step of HDR. Thus, we demonstrated that the circadian factor CRY1 drives circadian oscillations in DNA end resection, which results in circadian fluctuations in HDR. …
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Roles of AMPK in Drosophila circadian clock
국문요약 ⅰ 차례 ⅳ 그림 차례 ⅵ 표 차례 ⅶ Ⅰ. 서론 1 Ⅱ. 재료 및 방법 5 A. Schneider 2 (S2) 세포에서 발현시키기 위한 plasmid 5 B. S2 세포의 배양과 transfection 6 C. 형질전환 초파리 6 D. Locomotor Activity Monitoring System 8 E. 초파리 entrainment와 수확 8 F. 단백질액 추출 (lysis) 9 1. S2 세포에서 단백질액 추출 9 2. 초파리 머리에서 단백질액 추출 9 G. Immunoblotting (western …
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Cholinergic regulation of a mammalian circadian clock
… carbachol, has been shown to shift the phase of circadian rhythms in rodents when injected intracerebroventricularly. However, the site and receptor type mediating this action have been unknown. The suprachiasmatic nuclei (SCN), the primary circadian pacemaker in mammals, continue to show a …
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Coordination of the Arabidopsis thaliana circadian clock
… plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant. Thus, the clock may be set separately in cells creating discrepancies in …
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Protein localization during the cyanobacterial circadian cycle
Circadian clocks are ubiquitous throughout the living world. Of these circadian clocks, the simplest one is found in cyanobacteria - unicellular, photosynthetic marine organisms. Studies of the circadian clock of Synechococcus Elongatus PCC 7942 have shown that the circadian clock is independent of …
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Genetic noise in the cyanobacterial circadian oscillator
… creating a noisy intracellular environment. Circadian rhythms, driven by oscillators which provide cells with an internal clock that controls the gene expression program, have been observed in a wide range of organisms from cyanobacteria to mammals. To explore the impact of stochastic …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… cells may control distinct components of circadian behavior although these assignments are not rigid, and depend critically upon environmental conditions. Plasticity in the neural circuits controlling circadian behavior allow the animal flexibility in responding to fluctuations in …
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