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Showing 1 to 20 of 122 for “"Ciprofloxacin"”.
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Investigation of ciprofloxacin antibacterial combinations.
Ciprofloxacin, one of the most active fluoroquinolone antimicrobial agents, is bactericidal against a broad spectrum of Gram-positive and Gram-negative microorganisms, including Staphylococcus aureus and Pseudomonas aeruginosa. However, reports of decreased susceptibility to ciprofloxacin during …
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Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages
… and mechanism of accumulation for liposomal ciprofloxacin (Lipo-CPFX) into the rat alveolar macrophage NR8383 cells were studied in vitro, in comparison to unformulated ciprofloxacin (CPFX). Upon incubation with CPFX or Lipo-CPFX, cellular drug accumulation was determined from the cell …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
<p>Liposomal ciprofloxacin (Lipo-CPFX) is being developed for inhalation, with a goal of sustaining the therapeutic activity, compared to unformulated ciprofloxacin (CPFX). However, the kinetics and mechanism of its sustained local lung retention and pharmacological activity are yet to be fully …
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Synthesis, Physicochemical And Biopharmaceutical Characterisation Of Pro-Antibiotic Esters; Free Bases Of Ciprofloxacin
… This study was designed to synthesise esters of Ciprofloxacin, a model drug using alcohol co-formers (isopentanol, n-butanol and isobutanol) with a view to improving the physicochemical and biopharmaceutical properties of Ciprofloxacin. Three esters of ciprofloxacin were synthesised, i.e., …
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An integrated approach to ciprofloxacin susceptibility analysis and high-throughput bacterial phenotyping in Salmonella
… of Salmonella Typhimurium (S. Typhimurium) to ciprofloxacin, a fluoroquinolone, using a combination of methodologies. In particular, this work was targeted at better understanding ciprofloxacin susceptibility in invasive non-typhoidal S. Typhimurium in sub-Saharan Africa. I began by assessing …
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A Study of Antibiotic Resistance Plasmids in Fresh Produce and In Wastewater Environments Using Functional Approaches, Comparative Genomics and Abundance Analysis
… found in non-pathogenic environmental bacteria. Ciprofloxacin, meropenem and erythromycin are important clinical antibiotics due to their broad applications in the treatment of Gram-positive and Gram-negative infections. The capacity to capture, mobilise and control the expression of resistance …
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The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
… sensing to coordinate its group behaviours. Ciprofloxacin and trimethoprim were chosen as the antibiotic partners. Ciprofloxacin is commonly used against \textit{P. aeruginosa} but resistance to it is developing, whereas \textit{P. aeruginosa} is inherently resistant to trimethoprim. It was …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… and painless administration. Saquinavir and Ciprofloxacin, an antiretroviral and an antibiotic respectively, were chosen for their optimal properties, including bioavailability, half-life, and dosage. Saquinavir was encapsulated in the organic phase of biodegradable poly(lactide-co-glycolide) …
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Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
… to compare the ability of the fluoroquinolones ciprofloxacin and moxifloxacin to select resistance over three mutational steps, correlate changes in fluoroquinolone susceptibility with mutations in the QRDRs, examine the role of efflux using phenotypic tests, and investigate the expression of …
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Chemical Control and Understanding of Horizontal Gene Transfers, Drug-Resistance Development, and Filament and Biofilm Formation
… on tetracycline-enhanced plasmid transformation, ciprofloxacin-enhances PAPI-1 transduction, and PAPI-1 conjugation. Further study of ciprofloxacin-resistance development in P. aeruginosa is conducted by using serial passage assay. The inhibited development of MIC of ciprofloxacin suggest that …
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Evaluation of Antibiotic Drug Synergisms Against Periodontal Aggregatibacter Actinomycetemcomitans
… between amoxicillin plus metronidazole, between ciprofloxacin plus metronidazole, and between spiramycin and metronidazole, against clinical periodontal isolates of A. actinomycetemcomitans of United States origin. Methods: Standardized cell suspensions, equivalent to a 1.0 McFarland turbidity …
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Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
… and detoxification systems in the evolution of ciprofloxacin resistance under gradual or sudden antimicrobial exposure; and (iii) to determine the impact of deletion of the recA gene (the SOS response activator, also required for homologous recombination in E. coli) on the reversal of …
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Indagine sulla presenza di Helicobacter pullorum in allevamenti avicoli italiani
… poultry isolates, with different MIC values for ciprofloxacin and nalidixic acid, were compared. According to the PCR and PCR-RFLP results, 306 out of 366 animals examined were positive for H. pullorum (83,6%) and 96,1% of farms resulted infected. All positive samples showed a high number of …
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Stenotrophomonas maltophilia induzierte Endophthalmitis
… (TMP-SMX) 960mg bid i.v. and Ciprofloxacin 400mg -750mg bid p.o. for 10 days and TMP-SMX 960mg bid p.o. and Ciprofloxacin 250mg or 500mg bid p.o. for further 20 days, complemented with i.v. Fluorcortolone and topical treatment. Vision was examined before and during, 1 and 6 …
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Risk Factors for Acute Prostatitis after Transrectal Biopsy of the Prostate
… 10 patients who refused to be hospitalized, and ciprofloxacin was administered as antibiotic prophylaxis. The incidence, clinical features, pathogenic bacteria and potential risk factors associated with acute prostatitis after prostate biopsy were evaluated. RESULTS: Acute prostatitis developed …
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Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media
… We compare excised chinchilla TMs treated with ciprofloxacin (fluoroquinolone antibiotic) alone and with different combinations of sodium lauryl sulfate, limonene, and bupivacaine, with respect to resultant changes in TM electrical resistance and trans-TM ciprofloxacin flux. We also investigate …
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TOWARD A BETTER CLEANING AND SELECTIVITY IN ELECTROANALYSIS: TIO2-BASED SENSORS AND ENANTIOSELECTIVE MATERIALS
… for the photoelectrochemical detection of ciprofloxacin, a fluoroquinolone antibiotic. Titanium dioxide was coupled with gold nanoparticles (AuNPs) to enhance its signal and with mesoporous silica to increase the selectivity of the devices. At first, the focus was on the study of the aging …
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Computational Study on MFP MexA in MexAB-OprM and RND transporter AcrB in AcrAB-TolC Efflux Pumps
… AcrB variant showed an increased resistance to ciprofloxacin, suggesting a key role of the mutation in conferring the MDR. To study how the mutation, which is located in the distal binding pocket, might increase the efflux of ciprofloxacin we modeled AcrB structures for the wild type and the …
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