Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Cilia"”.
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Dynamics of Cilia and Flagella
Cilia and flagella are hair-like appendages of eukaryotic cells. They are actively bending structures that exhibit regular beat patterns and thereby play an important role in many different circumstances where motion on a cellular level is required. Most dramatic is the effect of nodal cilia whose …
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Characterisation of primary cilia in human hypothalamic neurons
Primary cilia are sensory organelles that protrude from the plasma membrane of most mammalian cells, including neurons. Among their roles, they are recognised to be involved in the control of feeding and energy expenditure by the hypothalamus. However, how cilia exert their role as signalling hubs …
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Ultrastructure and function of respiratory cilia in critical illness
… in the intensive care unit (ICU). The mucociliary transport system is the major defence mechanism against such infection and whilst its efficiency has been shown to be decreased in ICU patients there are few reports in the literature describing the ultrastructure of the respiratory …
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Role of WDR35 in the formation of functional cilia
Cilia are microtubule-based organelles present on the surface of almost all mammalian cells that play key sensory and sometimes motile functions. Defects in cilia structure or function lead to a group of human diseases called the ciliopathies. In order to function, cilia must maintain a distinct …
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Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
Primary cilia are non-motile organelles having 9+0 microtubules that project from the basal body of the cell. While the main purpose of motile cilia in mammalian cells is to move fluid or mucus over the cell surface, the purpose of primary cilia has remained elusive for the most part. Primary cilia …
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
Primary cilia (PC) are important sensory organelles which protrude from the epithelial cells lining bile ducts (cholangiocytes), where they serve as sensors of bile composition, flow and osmolality. PC malformation has been reported in cholangiocarcinoma (CCA), a neoplasia that originates from …
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TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
<p>Primary cilia are a small microtubule based signaling organelle. Primary cilia can be found on almost every mammalian cell, including neurons and glia. Tau Tubulin Kinase 2 (TTBK2) is a critical regulator of the building of primary cilia, and mutations within Ttbk2 cause the adult-onset, …
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The Roles of Primary Cilia in Cardiovascular Diseases and Cancer
<p>Primary cilia are sensory organelles present in most mammalian cell types and regulate cell cycle and signaling pathways. Biochemical and molecular dysfunctions of primary cilia are associated with a wide range of diseases, including cancer, ciliopathies polycystic kidney disease (PKD, liver …
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Understanding the Collective Dynamics of Motile Cilia in Human Airways
… rely on the coordinated beating of motile cilia for a multitude of fundamental reasons. In smaller organisms, such as Paramecium and the single cell alga Chlamydomonas reinhardtii, it is a matter of propulsion, to swim towards a higher concentration of nutrients or away from damaging …
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Immunohistochemical characterization of neuronal cilia in the rat central nervous system.
An anti-G"11 antibody was used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as …
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Structural characterization of primary cilia using accelerated piezoelectrically driven STED nanoscopy
Primary cilia are non-motile, hair-like projections occurring on most mammalian cell types. They play essential roles in transduction of chemical and mechanical signals across the cell membrane. For example, primary cilia are able to transduce sonic hedgehog signals, necessary in embryonic …
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The role of hydrodynamic forces in synchronisation and alignment of mammalian motile cilia
Fluid flow generated by a ciliated epithelium is a fascinating evidence of collective behaviour in nature. In many organs and eukaryotic organisms, thousands of microscale whip-like structures called 'motile cilia' beat aligned at the same frequency and in a coordinated fashion. This dynamics, …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
<p><strong>Background: </strong>Primary cilia are cellular organelles project from the cell surface of mammalian cell and play important roles in vertebrate development, organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in …
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Stiffness controls primary cilia position and length: mechanisms and potential in reversing osteoarthritis phenotypes
… to examine the role of substrate stiffness on cilia frequency, length and centriole position as well as cell and nuclei area over time in mouse articular chondrocytes. Contrary to other cell types, this study shows that chondrocyte primary cilia shorten on softer substrates demonstrating …
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Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons
… polarized transport to axons, dendrites and cilia in neurons are only partly understood. In this thesis, I describe my effort at understanding how neuronal proteins are asymmetrically localized. I pursued a genetic approach, employing the C. elegans nervous system as an in vivo model system …
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Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in a mouse model of spinal muscular atrophy
… the involvement in processes related to primary cilia. Assessments of primary cilia in the CNS in vivo and in primary neuronal cultures in vitro confirmed the presence of a primary cilia phenotype in SMA. Finally, to demonstrate that this observed novel phenotype is SMN-dependent, and amenable to …
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Sensory Primary Cilium is a Distinct Signaling Compartment
… from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship …
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Exploring Ciliary Dynamics: Assessing Motility and Induced Velocity in Human Airway Cell Cultures
… to the terminal bronchioles is lined by a mucociliated epithelium. Here, cilia underpin an essential defence mechanism known as MCC. This process clears inhaled pathogens and contaminants from the airways and exhibits various degrees of complexity. Differently from the case of microorganisms, …
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Identifying The Roles of miR-17 in Ciliogenesis and Cell Cycle
… suggests a significant contribution of primary cilia to cell division and proliferation mechanisms. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, …
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