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Showing 1 to 2 of 2 for “"Cicaprost"”.
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Asymmetrische Totalsynthese des hochwirksamen Prostacyclin-Analogons Cicaprost
An asymmetric synthesis of cicaprost and a formal asymmetric synthesis of isocicaprost by a new strategy are described. The key steps of theses syntheses are the coupling of chiral bicyclic C6-C14 alkyne building blocks with a chiral C15-C20 omega-side chain Weinreb-amide building block at the …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… MG was examined following 24 hr stimulation with cicaprost (CCP). A decrease in fibronectin and p27 was observed in cell lysates, and an increase in matrix metalloproteinase-2; CCP had no effect on thymidine or leucine incorporation. In response to 24 hr and 4 day HG, CCP- and iloprost (ILP)-cAMP …