Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Chronic wound"”.
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Antibacterial activity of polyunsaturated fatty acids related to chronic wound infections
Wound infections present major health problems worldwide. It has been revealed thatbacterial biofilm communities frequently colonise chronic wounds.Biofilms with Multidrugresistant organisms (MDRO) such as Methicillin Resistant Staphylococcus aureus (MRSA)and Pseudomonas aeruginosa are increasingly …
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Development and characterisation of medicated wound dressings for chronic wound healing
Chronic wounds are difficult to heal and exhibit physiological features including prolonged inflammatory phase, mixed bacterial flora resistance and formation of biofilms, ineffectiveness of topical antimicrobials and high volumes of wound exudate. Polymeric gels of Polyox (POL) and blends of POL …
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Laser-processed parchment paper for fabrication of chronic wound dressings with selective oxygenation
<p>Chronic non-healing wounds (e.g., diabetic foot ulcers and bed sores) impact over 6.5 million Americans per year, costs in excess of $25 billion to treat on an annual basis, and are on the rise due to increasing levels of obesity and diabetes compounded by an aging population. A major inhibitor …
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Using Optimal Control Theory to Optimize the Use of Oxygen Therapy in Chronic Wound Healing
… million people in the United States suffer from chronic wounds, which are defined as wounds that do not heal in 30 days time; an estimated $25 billion per year is spent on their treatment in the United States. In our work, we focused on treating chronic wounds with bacterial infections using …
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Application of a Numerical Method and Optimal Control Theory to a Partial Differential Equation Model for a Bacterial Infection in a Chronic Wound
… differential equations arising from a problem in wound healing. Optimal control theory is a generalization of calculus of variations, as well as the method of Lagrange Multipliers. Both of these techniques have seen prevalent use in the modern theories of Physics, Economics, as well as in the …
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Identifying barriers to accessing healthcare for chronic wounds in the Khayelitsha sub-district: a mixed methods study
Background: Chronic wounds impose a significant burden on health systems, as delayed access to care contributes to poorer clinical outcomes and increased healthcare costs. These delays are particularly pronounced within resource-constrained systems such as the South African public healthcare …
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The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… applications including possible cancer therapy, chronic wound healing and nanoparticulate drug delivery systems. However, due to their individual complexities, there is limited physico-chemical analysis relevant to their drug delivery applications. The aims of this research are the systematic …
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Developing information systems technology within NHS wound clinics: an evaluation
… Health Service (NHS) healthcare organisation. Chronic wound healing is a complex activity, with a long history and strong dependence on data, as observed and recorded by clinicians, to treat and heal patients. Wound clinics that are part of the NHS, which is currently actively pursuing a …
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Development of a simplified negative pressure wound device
… constraints. For these reasons, a successful, chronic wound treatment, known as negative pressure wound therapy (NPWT), has not been readily used, although many patients would benefit. Aiming to expand this therapy, the viability of inexpensive, purely mechanical simplified negative pressure …
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Green synthesis and characterization of gold nanoparticles from capparis sepiaria-tabernaemontana elegans cocktail and investigation of their biological effects in vitro.
Wounds have a significant impact on the global healthcare system, adding heavy load on the economy and society. therefore, there is an urgent need to develop treatments that can facilitate rapid wound healing. to make matters worse wound infection by antimicrobial-resistant bacteria may result in …
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Fibroblasts as matrix modulating cells in asthma and COPD
Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound …
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How adults with type 2 diabetes and a chronic lower extremity wound understand the link between their wound and their diabetes management
… do people with type 2 diabetes who also have a chronic lower wound understand about the management of their condition and the complication of a wound? With the number of people with type 2 diabetes in New Zealand growing so rapidly so are the number of people experiencing complications …
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HORMONE EPIMERS REGULATE ER STRESS AND CORE REGULATORY GENES: NETWORK ANALYSIS WITH APPLICATIONS TO GLIOMA AND CHRONIC PRESSURE ULCERS
… signaling pathways and core regulators. Chronic pressure ulcers represent a significant health problem and are characterized by hypoxia, bacterial infection, repetitive ischemia/reperfusion and altered cellular and systemic stress responses. Whole genome microarray analysis was utilized …
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Exploring the Biomedical Applications of Polyurethane-based Foams, Films, and Hydrogels
… use in tissue engineering, drug delivery, and wound healing applications.<p>In the second chapter, low density porous foams with tunable degradability were developed for their use in tissue engineering applications. In vitro degradation profiles were compared to in vivo degradation profiles to …
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Improving the precision of leg ulcer area measurement with active contour models.
A leg ulcer is a chronic wound of the skin that, at best, takes many months to fully heal and causes great distress to the patient. Treating leg ulcers places a large financial burden upon the National Health Service in the United Kingdom, estimated to be in excess of £300M …
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A WIRELESS ELECTRICAL STIMULATION SYSTEMFOR WOUND HEALING THERAPYWITH BIPHASIC HIGH-VOLTAGE PULSED CURRENT OUTPUT
… systems have been developed for use in wound electrotherapy. These self-contained, battery-powered bandages have been demonstrated in-vivo using both a rat chronic wound model and a pig infected wound model and provide a new means to investigate the physiological mechanisms of wound …
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Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
BACKGROUND: Periodontitis is a chronic inflammatory disease characterized by progressive destruction of tooth-supporting tissues and can be conceptualized as a dysregulated, non-healing wound. While bulk transcriptomic studies have provided insight into inflammatory pathways, single-cell RNA …
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The role of ERK5 signalling in macrophage behaviour during wound healing
… individuals worldwide are affected by impaired wound healing, which can lead to chronic wound pathologies that often require lower limb amputations. Impaired wound healing is particularly prevalent in two growing demographics: aged and diabetic populations. Impaired wound healing continues to …
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Studying Myeloid Cell Heterogeneity After Spinal Cord Injury via Time-Resolved Single-Cell RNA Sequencing
… We now understand that compared to the normal wound healing observed in the periphery, tissue recovery after SCI is dysregulated and results in a chronic wound state characterized by persistent inflammation and functional deficits. The primary drivers of this inflammation are central nervous …
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