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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 21 for “"Chronic myeloid leukemia"”.

  1. Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia

    Hansen, NilsDivision of Clinical Genetics, Lund University2013

    Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. However, …

    lund Repository record

  2. Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia

    Saglio, Giuseppe, Houshmand, MohammadUniversità degli Studi di Torino2021

    unito Repository record

  3. USE OF Drosophila melanogaster AS A MODEL TO STUDY CHRONIC MYELOID LEUKEMIA

    Cilloni, Daniela, Signorino, ElisabettaUniversità degli Studi di Torino2020

    unito Repository record

  4. Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia

    Zhang, Hui2013

    <p>Chronic myeloid leukemia (CML), a myeloproliferative disorder, represents approximately 15-20% of all adult leukemia. The development of CML is clearly linked to the constitutively active protein-tyrosine kinase BCR-ABL, which is encoded by <em>BCR-ABL</em> fusion gene as the result of …

    uthsc Repository record

  5. Investigating the Determinants of Treatment-Free Remission in Chronic Myeloid Leukemia: Insights from a Nationwide Real-World Study (ITALYTFR Registry)

    Cilloni, Daniela, Bonuomo, ValentinaUniversità degli Studi di Torino2026

    unito Repository record

  6. Evolução da leucemia mielóide crônica frente à terapia com inibidores de tirosina cinase.

    Medeiros, Leanio Eudes dos SantosUniversidade Federal da Paraíba2014

    The Chronic Myeloid Leukemia (CML ) is a myeloproliferative disease by developing skilled clone of hematopoietic cells carrying Philadelfia chromoso me ( Ph ) , deriving the respective translocation between the long arms of chromosomes 9 and 22 , t( 9:22) (q34;11 ). As a result of this molecular …

    brazil-ufpb Repository record

  7. Ocorrência de eventos adversos relacionados a inibidores de tirosina quinase de primeira e segunda geração : revisão de literatura

    Nascimento, Mayara Maciel doUniversidade Federal da Paraíba2016

    Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a translocation between the long arms of chromosomes 9 and 22. The translocation of these chromosomes results in the juxtaposition ABL oncogene on chromosome 9 wit h the BRC housekeeping gene of chromosome …

    brazil-ufpb Repository record

  8. Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants

    Rogers, Rosemary, <p>https://orcid.org/0000-0002-1799-238X</p>2022

    <p>Therapy-related myeloid neoplasms (t-MN) are rare and deadly hematologic malignancies that develop following exposure to cytotoxic therapies such as radiation, chemotherapy, and poly (adenosine diphosphate-ribose)-ADP polymerase (PARP) inhibitors. Preliminary evidence suggests that germline …

    uthsc Repository record

  9. Trim24 In Normal & Malignant Hematopoiesis

    Shaw, Justin, <p>https://orcid.org/0000-0001-7166-1322</p>2019

    <p>Treatment for acute myeloid leukemia (AML) has changed little in the past four decades. For the majority of AML patients, current treatment options include chemotherapy and allogeneic stem cell transplants, which also involves high-dose chemotherapy or radiation treatment. These options have …

    uthsc Repository record

  10. The Relationship Between Uncertainty in Illness and Anxiety in Patients With Cancer

    Vera, NaimaDigital Commons @ University of South Florida2009

    … cancer (n=3), or pancreatic cancer (n=2), acute myeloid leukemia (n=2), sarcoma (n=2), lung cancer (n=2), myeloma (n=2), chronic myeloid leukemia (n=1), glioblastoma (n=1), and rectal cancer (n=1). Seventy percent of the patients had stage IV disease. The results of the study showed a significant …

    usf Repository record

  11. Development and application of a general method for somatic cell genetics

    Wang, TimMassachusetts Institute of Technology2017

    … proliferation and survival of the nearhaploid chronic myeloid leukemia cell line, KBM7. The unusual karyotype of these cells also allowed an independent screening approach, involving gene-trap insertional mutagenesis, to find cell-essential genes. Together, these screens converged on a highly …

    mit Repository record

  12. Lariat peptide inhibitors of Abl kinase

    Vellalore Maruthachalam, BharathikumarUniversity of Saskatchewan2013

    … against Abl kinase, a drug target important in chronic myeloid leukemia and other disorders. Using a yeast two-hybrid approach, we first isolated two related lariats, named A1 and A2, from a pool of five million lariats, which interact with the catalytic domain of Abl kinase. In vitro studies …

    sask Repository record

  13. Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms

    Ågerstam, HelenaSection of clinical genetics2010

    … underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, chronic phase that after some time progresses into acute myeloid or lymphoid …

    lund Repository record

  14. GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA

    Abrishami, MahsaUniversity of Saskatchewan2019

    … to block innate imatinib resistance in chronic myeloid leukemia (CML). Tyrosine kinase inhibitor (TKI), imatinib, is the standard therapy for CML. Although many patients respond to the conventional TKI chemotherapy, the majority relapse upon withdrawal of treatment (Ross et al., 2013) …

    sask Repository record

  15. Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma

    Vishwamitra, Deeksha2010

    … of IGF-IR in some types of T-cell lymphomas and chronic myeloid leukemia. Constitutively active IGF-IR induces its oncogenic effects through the inhibition of apoptosis and induction of transformation, metastasis, and angiogenesis. Previous studies have shown that signaling through IGF-IR leads …

    uthsc Repository record

  16. Exploration of Transition Metal Catalyzed C−C and C−N Bond Formation to Access Synthetically Elusive Small Molecules

    Dixon, Alexandre

    … Pfizer in 2012 for the treatment of late stage chronic myeloid leukemia (CML). Bosutinib acts as a Src selective non-Receptor Tyrosine Kinase (nRTK) inhibitor, and it has also shown inhibition of breast and prostate cancer cells and suppression of solid tumors. Until recently, Src was originally …

    syracuse-diss Repository record

  17. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

    Vidovic, KarinaLund University, Faculty of Medicine2010

    … into mature blood cells. However, most primary leukemias express high levels of WT1 at diagnosis and this is an independent predictor of adverse outcome. In paper I, I demonstrate that WT1 expression is induced by tyrosine kinase signalling from BCR/ABL1 via the PI3K/Akt pathway. Chronic myeloid …

    lund Repository record

  18. Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications

    CIAFFAGLIONE, VALERIAUniversità degli studi di Catania2022

    … for new TK/HO-1 hybrid inhibitors to target chronic myeloid leukemia (CML). Their cytotoxic effects were studied on NIL-resistant and sensitive K562 cells. Docking studies explained the different interactions with BCR-ABL and HO-1 proteins. The last stage of this thesis was the design and …

    catania Repository record

  19. COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN

    Pearce, ClaireUniversity of Birmingham2009

    … down in the human haematopoietic cell line and chronic myeloid leukemia model, K562. Both knockdowns had similar consequences for CRL activity whilst having divergent effects on the levels of SRS mRNA. Knockdown of either subunit also resulted in a common sequential proteasome-dependent loss of …

    birmingham Repository record

  20. Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins

    Shen, Min2013

    … bortezomib-resistant counterparts generated by chronic drug exposure were used. In this study, I found that paired bortezomib-sensitive and -resistant multiple myeloma cells were about equally sensitive to AMPK activators metformin and AICAR. Although carfilzomib is developed as next-generation …

    wayne-thes Repository record

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