Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Chronic lymphocytic leukemia (CLL)"”.
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Development and study of a monoclonal antibody to the human HLA-class II invariant chain
… to the peripheral blood cells of a patient with chronic lymphocytic leukemia (CLL). It was initially hoped that such an antibody, if directed against an idiotypic determinant on the malignant B-cell surface, may prove to be useful therapeutically by virtue of its specificity and limited …
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From Oncogenesis to Immunotherapy: Mathematical Modeling of Heterogeneous Cancers
… with substantial mutational heterogeneity: chronic lymphocytic leukemia (CLL) and mismatch-repair deficient colorectal cancer (MMR-D CRC). First, to study the progression of CLL into an aggressive lymphoma, Richter’s Syndrome (RS), we analyze data from a recent mouse model and utilize a …
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Cll Metabolism Is Regulated By Prognostic Factors, Modulated By Stroma and Abrogated By Pi3K Inhibition
<p>Metabolism of chronic lymphocytic leukemia (CLL), a disease characterized by the relentless accumulation of mature B cells has been little explored. Bone marrow stromal cells provide a survival benefit to CLL cells, in part through PI3K/AKT pathway. Compared with proliferative B-cell lines, …
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Biological and medical implications of discordance in CpG methylation
… heterogeneity, and adverse clinical outcome in chronic lymphocytic leukemia (CLL). Our analytic approach introduces a novel perspective on utilizing epigenomic sequencing data, which we anticipate will be a valuable tool in understanding the regulation of DNA methylation and its contribution to …
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Cancer risk prediction with next generation sequencing data using machine learning
… the problem in the whole exome NGS data of the chronic lymphocytic leukemia (CLL) available at dbGaP. Initially, raw reads from samples are aligned to the human reference genome using burrows wheeler aligner. From the samples, structural variants, namely, Single Nucleotide Polymorphism (SNP) and …
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Untersuchungen über Veränderungen des Epigenoms bei der chronischen lymphatischen Leukämie
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. Apart from chromosomal alterations comprising deletions and numeric aberrations there is increasing evidence that epigenetic processes contribute to the malignant phenotype of CLL. There is no known pathogenic …
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EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES
… large B-cell lymphoma (DLBCL), acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL), alongside two cohorts of healthy donors. We identified 21, 19, and 16 disease-specific heteroplasmic mtDNA missense mutations in DLBCL, AML, and CLL, respectively. These alterations frequently …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… well-annotated tumor cohorts of CRC and chronic lymphocytic leukemia (CLL) patients. The ncUCE mutation rate correlates well with clinical features of CRC, while CLL patients with the worst prognosis, Richter Transformation, harbor ncUCE mutations in regulators of key cancer genes for …
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The role of type I interferon in chronic lymphocytic leukemia
… of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult leukemia. CLL cells were found to exhibit the capacity to both produce and respond to autocrine IFN. Leukemic cells from patients with clinically aggressive disease expressed higher IFN …
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Subclonal Evolution of Chronic Lymphocytic Leukemia After Allogeneic T Cell Therapies
<p><strong>Subclonal evolution of chronic lymphocytic leukemia after allogeneic T-cell therapies</strong></p> <p>Haven Garber, MD</p> <p>Advisory Professor: Jeffrey Molldrem, MD</p> <p>Intratumoral genetic heterogeneity describes the molecular differences among subclones within a tumor and is a …
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Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia
<p>In chronic lymphocytic leukemia (CLL), one of the best predictors of outcome is the somatic mutation status of the immunoglobulin heavy chain variable region (IGHV) genes. Patients whose CLL cells have unmutated IGHV genes have a median survival of 8 years; those with mutated IGHV genes have a …
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Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
<p>Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia diagnosed in Western countries and is characterized by clonal expansion of B cells. The clinical course of CLL is diverse and nearly 50% of patients present with chromosomal abnormalities. Deletion of the short arm on …
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TOX2 and TOX at the intersection of central memory and exhaustion in human CAR T cells
… showing remarkable efficacy in cancers such as leukemia and lymphoma. However, the success of CAR T therapy in treating solid tumors has been limited due to T cell exhaustion, which limits their proliferation and cytotoxicity when chronically stimulated with antigen, such as in cancer. Genetic …
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Role of Gsh Metabolism In Mediating Stromal-Leukemia Interaction and Promoting Cell Survival and Drug Resistance In Chronic Lymphocytic Leukemia
<p>Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries. The interaction between CLL cells and the bone marrow stromal environment is thought to play a major role in promoting the leukemia cell survival and drug resistance. My dissertation works proved a …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
<p>Chronic lymphocytic leukemia (CLL) is a B-cell malignancy. High levels of Bcl-2 and IAP family proteins are responsible for apoptotic-resistance and accumulation of mature CLL lymphocytes in bone-marrow, lymph nodes and peripheral blood. Besides pro-survival proteins, supporting stromal cells as …
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Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
… tumors and in hematologic malignancies.</p> <p>Chronic lymphocytic leukemia (CLL) is driven by B-cell receptor (BCR) signaling that promotes B-cell proliferation and survival. PI3K is a critical node in BCR pathway and PI3Kδ has a pivotal role in B-cell development and maintenance and this …
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Épissage alternatif et mutations ponctuelles de Pax5 chez la leucémie lymphoîde chronique et les lymphomes de cellules B
… as non-Hodgkin lymphoma and acute lyrnphoblastic leukemia. Recent studies have revealed that the Pax5 transcript is subject to alternative splicing, thus producing multiple protein isoforms. Certain splicing events create a shift in the reading-frame and thus generate novel protein sequences, …
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Array based genetic profiling of chronic lymphocytic leukemia
… no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas …
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“Watch and Wait” - Examining the potential impact of uncertainty in illness on the mental health of individuals with Chronic Lymphocytic Leukemia and Low Grade Lymphomas
Chronic lymphocytic leukemia (CLL) and non-localised low grade or indolent lymphomas (LGL) are two of the common cancers that individuals are diagnosed with in the UK. Both of these chronic illnesses are considered slow growing and these individuals are often diagnosed when one is not exhibiting …
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GENOMIC AND EPIGENETIC APPROACHES IN THE CLINICAL AND PROGNOSTIC STRATIFICATION OF CHRONIC LYMPHOCYTIC LEUKEMIA
Chronic lymphocytic leukemia (CLL) is characterized by highly clinical heterogeneity; the identification of factors that could predict the clinical course of early-stage CLL represents a crucial objective in this malignancy. The aim of the study is to identify novel biological markers that may be …
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