Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Chronic lung disease"”.
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Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease
Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension …
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The effect of long-term azithromycin treatment on the respiratory microbiota of HIV-infected children with chronic lung disease
Background: HIV-associated chronic lung disease (HCLD), predominantly obliterative bronchiolitis, affects more than 30% of perinatally HIV-infected children in Sub-Saharan Africa. There are currently no treatment guidelines for HCLD. A recent clinical trial demonstrated that long-term azithromycin …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5 - 8 million individuals worldwide and 200,000 individuals in the United States alone. Although prevalent, we do not know what causes IPF and no effective curative treatment exists for this disease. Our laboratory has …
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A retrospective review of lung disease in adolescents living with human immunodeficiency syndrome
Chronic lung disease (CLD) is common in adolescents living with Human Immunodeficiency Virus (ALHIV), many of whom have survived early childhood respiratory infections and immune dysregulation. Little is known about the characteristics of ALHIV with CLD. Understanding the characteristics of this …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
Chronic lung diseases and acute lung injuries are two distinctive pulmonary disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through …
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Bronchiectasis in African children: disease burden, aetiology and clinical spectrum at a paediatric tertiary hospital in Cape Town, South Africa
Childhood bronchiectasis is a common cause of chronic lung disease globally, particularly in lower-middle-income countries (LMIC). Data from LMIC is lacking. We aimed to describe the disease burden, aetiology, and clinical spectrum of bronchiectasis in children attending a tertiary hospital in Cape …
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Lung function in perinatally HIV-infected adolescents on antiretroviral therapy in Cape Town, South Africa
Background: Lung disease is a common complication of human immunodeficiency virus (HIV) infection in children and adolescents. As antiretroviral programmes have strengthened and HIV diagnosed earlier, survival of perinatally HIV-infected children has improved. Therefore, an increasing number of …
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The effect of hypoxia on the cytotoxicity of diesel exhaust particles and a novel oxygenating therapeutic in four cell lines.
… in tissue below 2% and is implicated in many diseases and adverse health outcomes including chronic lung disease, neurodegenerative diseases, and delayed wound-healing. Many solutions for tackling hypoxia to alleviate such conditions have been proposed but all carry significant limitations. …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …
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Immune Dysfunction in Cystic Fibrosis
… of the most widespread life-shortening genetic diseases. CF is often diagnosed at birth; there is no cure, and many CF patients die from chronic lung disease at a young age. Patients with CF experience declining pulmonary function related to chronic airway infection, inflammation and scarring. …
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SOCIOECONOMIC STATUS, AIR QUALITY, AND ASTHMA PREVALENCE TO ASSESS ENVIRONMENTAL JUSTICE IN PHILADELPHIA
… in the United States suffer from asthma, a chronic lung disease that makes it difficult to breathe. Environmental factors, such as air quality, contribute to asthma prevalence. Unfortunately, socioeconomic status is also a key risk factor for asthma, where people of color or of low-income …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… and has been implicated in the pathogenesis of chronic lung diseases. Previous studies have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> adenosine receptor in various cell types, including alveolar macrophages. IL-6 is elevated in mouse …
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Efeitos dos programas de qualidade de vida dos usuários do SUS com doença obstrutiva crônica: Revisão da Literatura
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that decreases the ability to breath. The physical, emotional and intellectual limitations that come with the disease, with consequences in the lives of patients and their families , generate human suffering , …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix …
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Antimicrobial and immuno-modulatory peptides as a treatment for lung disease and delivery by nebulisation
… are of significant concern for individuals with chronic inflammatory lung diseases and there is an unmet need for novel antibiotics. Antimicrobial peptides possess antibiotic potential due to their antimicrobial and/or immunomodulatory properties. The project aim was to assess the therapeutic …
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Hypoxia and the regulation of host responses to acute bacterial pulmonary infections
… morbidity and mortality. However, patients with chronic lung disease function in the community with chronic systemic hypoxaemia and bacterial colonisation with much lower acute mortality. The HIF/PHD pathway tightly regulates neutrophilic responses to hypoxia and bacteria. Here, using acute …
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Adenovirus-associated pneumonia in South African children : presentation, clinical course and outcome
… Outcome measures were death and development of chronic lung disease (CLD). Results: 1910 respiratory samples were submitted to the NHLS from which 206/1910 (11%) AVP cases were identified. The median age was 12 months (IQR 6-24), 70 (34%) children were malnourished and 14 (7%) HIV-infected. …
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