Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Chronic low-grade inflammation"”.
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… unhealthy phenotype, which is characterized by chronic low-grade inflammation, insulin resistance, and ectopic lipid accumulation. Research has implicated synthetic (i.e., Bisdehydrodoisynolic acid, BDDA) and natural (i.e., genistein and daidzein) xenoestrogens in the protection against …
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Proposed in vitro model of neutrophil swarming in a chronic, low-level inflammatory state
Chronic, low-grade inflammation is an underlying condition across a globally increasing number of debilitating diseases. These diseases include obesity, atherosclerosis, and diabetes and their resultant low-grade inflammation can be effectivity modeled with low dose stimulants such as …
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Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
… presence of macrophages, possibly reflecting a chronic, low-grade inflammation. We also found that crypt fission, not cell proliferation, was the main repair mechanism after one week post-irradiation and onwards. In Papers III & IV, we studied the effect of bioprocessed oat bran, rich in dietary …
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A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
… cardiometabolic disease features, biomarkers of chronic low-grade inflammation and type 2 diabetes; (3) to explore whether central adiposity indices provide additional information regarding disease and risk status, compared to general adiposity characterised by body mass index (BMI); (4) to …
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Obesity Related Perturbations On Cardiovascular, Immune And Endocrine Response To Active And Passive Stress
… simultaneously. The internal environment of chronic low-grade inflammation, which characterizes obesity, leaves individuals vulnerable to disease. Cardiovascular dysfunction represents a consequential effect of obesity. An early indicator of cardiovascular disease is an impaired stress …
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Oxidative Stress and Inflammation in the Heterogeneity of Metabolic Health
… indicators such as body mass index (BMI). Chronic low-grade inflammation and oxidative stress are key mechanisms linking metabolic dysfunction to cardiometabolic disease, but their interaction across metabolic health phenotypes and clinical conditions remains insufficiently understood. This …
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Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging
Obesity and aging are often accompanied by chronic low-grade inflammation in adipose tissue. Metabolic endotoxemia (elevated circulating lipopolysaccharide [LPS] level) is the inducer of systemic and adipose tissue inflammation and dysfunction, which is developed during obesity and aging. As a …
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Prebiotic supplementation with inulin and exercise influence gut microbiome composition and metabolic health
… a metabolically "atypical" state associated with chronic low-grade inflammation, overweight and obesity, lack of exercise, and detrimental changes to the gut microbiome. Dietary intake and exercise are modifiable lifestyle factors for reducing T2D risk; however, several questions remain unanswered …
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GENETIC CHARACTERIZATION OF THE ST. KITTS-ORIGIN VERVET MONKEY (CHLOROCEBUS AETHIOPS SSP.) AS A MODEL OF POLYGENIC OBESITY
… (TNF) is a cytokine with critical roles in inflammation, and in mediating an intersection of chronic, low-grade inflammation and concurrent metabolic dysregulation associated with obesity and its comorbidities. As part of an ongoing initiative to further characterize the St. Kitts-origin …
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The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity
… metabolic dysregulation occurs in concert with chronic low-grade inflammation. Toll-like receptors (TLR) are transmembrane receptors that play an important role in innate immunity and the induction of inflammatory responses. Our laboratory has observed that TLR4 expression is elevated in the …
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… diseases. Obesity is also linked with chronic low-grade inflammation. The placenta plays a central role in mediating metabolic and inflammatory effects of the gestational environment on fetal growth and serves as a critical determinant of long-term offspring health. This project aims to …
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Hempseed oil as a novel source of polyunsaturated fatty acids and its effect on inflammation in sedentary horses
Chronic, low-grade inflammation is a contributing factor in diseases that impact the health and well-being of horses. Pharmaceutical treatments reduce inflammation, but their use results in negative digestive and kidney disturbances. Polyunsaturated fatty acids (PUFA) play a role in mitigating the …
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A influência da perda de peso no perfil inflamatório de mulheres com síndrome dos ovários policísticos
… insulin resistance (IR), visceral obesity, chronic low-grade inflammation and dyslipidemia. Due to the high frequency of obesity associated with PCOS, weight loss is considered as the first-line treatment for the syndrome by improving metabolic and normalizes serum androgens, restoring …
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Long COVID related inflammatory processes. What is its impact on bone, joints and musculoskeletal microvascular haemodynamics?
… Long COVID (LC) refers to persistent symptoms following acute COVID-19 recovery, including fatigue, musculoskeletal (MSK) pain, and reduced quality of life. It has been hypothesised that chronic low-grade inflammation in LC could affect bone metabolism, joint health, and skeletal muscle …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
Introduction: Obesity is a chronic complex disease that poses the risk of developing a plethora of serious health complications (e.g., type 2 diabetes, cardiovascular and cerebrovascular disease, and cancers). Browning of white adipose tissue (WAT) can drain excess nutrients via thermogenesis and …
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AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
… and maintenance of an optimal weight, and the chronic low-grade inflammation that accompanies obesity is implicated as a causal factor in the development of cancer. Flaxseed, a rich plant source of anti-inflammatory omega-3 fatty acids and lignans which act as phytoestrogens and antioxidants, …
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The effects of whole-diet interactions on vascular health and inflammatory and fatty acid status.
… acid (EPA) and docosahexaenoic acid (DHA)) on chronic low grade inflammation (primary end-point) in 1250 older adults (aged 65-79 years) in five EU centres. As part of this thesis, the impact of intervention on vascular ‘health’ was established. In addition, a diet score for older adults was …
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Lifestyle and exercise effects on circulating progenitor cells in children and adults
… obesity in adulthood. Obesity is associated with chronic low-grade inflammation characterized by elevating inflammatory proteins and a chronically activated immune system, which is maintained by circulating progenitor cells (CPCs). CPCs are a heterogeneous population of cells that are capable of …
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The effect of single nucleotide polymorphisms of oxidative stress genes and low grade inflammation upon pulse wave contour analysis, a useful non invasive, intermediate vascular phenotype.
… both biochemical markers of oxidative stress and low grade chronic inflammation as well as a non invasive vascular phenotype, pulse wave analysis. This thesis reports a series of studies (utilising the techniques described in chapter 2) which aimed to ascertain:- The reproducibility of pulse …
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Epigenetics, a signal sensor of dietary components, is involved in the hepatic gene regulation
… consequently contribute to the early onset of chronic disease and metabolic disorder [3]. Sustained high fat feeding leads to obesity and metabolic syndrome, accompanied by low-grade inflammation, insulin resistance, and dyslipidemia. In general, the prevalence of an inflammatory response is …