Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 275 for “"Chronic inflammation"”.
-
Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury
This thesis investigated the influence of chronic inflammation on several neural/behavioural disorders following spinal cord injury (SCI) including depression, cognitive impairment, neuropathic pain, and somatic nerve deficits. Ample evidence exists to suggest that the immune system communicates …
-
Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
Sepsis and chronic inflammation remain unresolved clinical challenges due to immune dysregulation. Innate immune cells, particularly monocytes, are key regulators of inflammation and its resolution. However, unbalanced or prolonged stimulation can drive these cells into dysfunctional states. These …
-
The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
Fibroblasts are important regulators of inflammatory processes. The phenotype of fibroblasts differ according to anatomical site which may dtermine immune functions such as leukocyte accumulation and predilection for inflammatory disease in certain tissues. This thesis describes the expression …
-
Obesity in chronic inflammation using rheumatoid arthritis as a model: definition, significance, and effects of physical activity & lifestyle
Background: Inflammation is the natural reaction of the body to an antigen. In some conditions, this reaction continues even after the elimination of the antigen, entering a chronic stage; it targets normal cells of the body and causes extensive damage. Rheumatoid arthritis (RA) is such a …
-
Identification of potassium channel subtypes mediating the PGE2-induced sensitization of sensory neurons and regulation of potassium channel gene expression by chronic inflammation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Social antecedents and health consequences of productive activity
… replicating analyses of productive activity and chronic inflammation in a Korean sample, and (c) examining sleep as a potential mediator and moderator of the relationship between productive activities and chronic inflammation. Chapter 2 attempted to contribute to the knowledge on productive aging …
-
Developing a vector for expressing serratiopeptidase in Lactococcus lactis
<p>Chronic inflammation stems from the inability of the body to resolve acute inflammation. Chronic inflammation is a growing health concern, as nearly 60% of Americans reported coping with at least one chronic condition (as of 2014). On a world scale, three fifths of deaths result from a chronic …
-
DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
… It is thought that cancer risk is based on chronic inflammation of the gastrointestinal mucosa. There have been many studies, which have supported this idea and have made progress toward understanding the link between chronic inflammation and cancer. In both UC and CD, it is known that there …
-
Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes
While a link between chronic inflammation and cancer has been established, the mechanisms of genotoxicity in inflammatory environments remain poorly understood. We hypothesized that inflammation may provide cues that allow cells to survive in the face of significant DNA damage as well as cues that …
-
Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
… proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since galectins have been …
-
Relationships between psychological factors and immune dysregulation in context: a life-course approach
… adversities predict onsets of each disease. Chronic as opposed to acute adversities are salient for rheumatoid arthritis onset, which is consistent with existing theory that chronic stress contributes to immune dysregulation. Depressive symptoms mediate an association between childhood …
-
Refinement of the Docking Component of Virtual Screening for PPAR
… applications for treating a wide variety of chronic inflammation-related diseases. Type 2 diabetes (T2D), which is a metabolic disease influenced by chronic inflammation, is quickly reaching epidemic proportions. Although some treatments are available to control T2D, more efficacious …
-
Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… etiologies such as insulin resistance (IR) and chronic inflammation. While it was once believed that the brain was not susceptible to the peripheral environment, it has now been demonstrated that systemic conditions impact the brain, especially so in metabolic conditions such as T2D, where blood …
-
Safety of Slow Release Lipopolysaccharide (LPS) Pellet in a Swine Model and Development of an Exogenous Reference Control for Real Time PCR
<p>Natural induction modes of chronic inflammation associated with obesity (CIAO) are difficult to characterize and even more difficult to replicate in humans due to interand intra-variation in individuals and initiating conditions. Variables that can influence resistance to the development of CIAO …
-
The emerging role of mesenchymal stromal cells among therapeutic options for chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Smoking is the primary known risk factor in the development of COPD. Noxious particle or gas exposure to cells in the lungs leads to a chronic and sometimes irreversible state of airway inflammation, …
-
Inflammatory Biomarkers, Genetics, and Survival among Colorectal Cancer Patients
Chronic inflammation significantly increases the risk of colorectal cancer (CRC) through inflammation-mediated mechanisms. Current evidence regarding the connection between circulating inflammatory biomarkers and CRC prognosis is limited to C-reactive protein (CRP) and interleukin (IL)-6. However, …
-
Non-resolving pro-inflammatory macrophage polarization by super-low doses of bacterial endotoxin
… has been observed in patients suffering from chronic inflammatory diseases such as atherosclerosis, diabetes, and obesity. However, the link between this condition and chronic inflammation is poorly understood. Previous work from our lab has shown that chronic exposure to super-low doses of …
-
Intestinal cancer : linking infection, inflammation and neoplasia
… Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular targets, including DNA. The multistep model of cancer proposes that cancer is a genetic disease in which mutations are …
-
Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… therapy (ART) continue to suffer from chronic inflammation, dental diseases, and increased rates of depression, despite substantial viral suppression. The endoplasmic reticulum (ER) stress sensor, protein kinase R–like endoplasmic reticulum kinase (PERK), encoded by EIF2AK3, is a …
Page 1 of 14