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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Chronic hypoxia"”.
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Chronic Hypoxia and Cardiovascular Dysfunction in Sleep Apnea Syndrome
… current study was to test the hypothesis that chronic hypoxia associated with sleep-disordered breathing relates to abnormal Nitric Oxide (NO) production and vascular endothelial growth factor (VEGF) expression patterns that contribute to aberrancy of specific determinates of cardiovascular and …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
… of this project was to elucidate the role of chronic hypoxia in the programming of the cardio-protective gene, Protein Kinase C epsilon (PKCε) in fetal rat heart. We used an animal, organ base, and cell culturing with the rat embryonic cell line H9c2 to determine the molecular events …
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VEGF and Sympathetic Perivascular Nerves Contribute to Hypoxic Remodeling of Ovine Cranial Arteries
Chronic hypoxia complicates many pregnancies and can result in postnatal pathologies that include compromised fetal cardiovascular structure and function. Mechanisms involved remain unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis …
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Expression and Function of Ca2+-Activated K+ Channels in Uterine Arteries
<p>Chronic hypoxia during pregnancy is one of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
<p>Intrauterine hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases …
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The role of acute ambient hypoxia in the regulation of myostatin
When exposed to chronic hypoxia by pathophysiological or environmental causes humans show muscle atrophy, challenging homeostasis and increasing mortality rate. Chronic hypoxia also presents with elevated myostatin peptide, a negative regulator of muscle size. This work induced acute hypoxia in …
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Effects of Long-Term, High-Altitude Hypoxemia on Fetal Ovine Coronary Arteries
… arteries. We have found that in response to chronic hypoxia, isolated fetal ovine coronary arteries exhibit attenuated contractile responsiveness to potassium and the thromboxane A2 mimetic. U46619. Furthermore, long-term, high-altitude hypoxia produced no significant alteration in the …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
Chronic hypoxia, in animals and man, results in remodelling of the pulmonary vasculature with consequent pulmonary hypertension. The pulmonary artery fibroblast (PAF) has been shown to play an early and important role in hypoxia-induced pulmonary vascular remodelling. In acute and chronic hypoxia …
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Hypoxia signalling regulates human lung epithelial cell fates
… tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of …
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Pathophysiological changes in cardiomyocyte metabolism and bioenergetics during stress-induced cardiomyopathy.
… were expose to extreme dose of isoprenaline and chronic hypoxia. Real-time cell metabolic analysis, total lipid analysis, high-performance liquid chromatography (HPLC) and mass spectrometry for lipidomic spectrum detection, real-time polymerase chain reaction (RT-PCR) and Western blot for …
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Investigating Environmental Change Due To Hypoxic Conditions On The Louisiana Continental Shelf: A Geochemical Approach
The Louisiana (LA) shelf is chronically affected by seasonal hypoxia that has been shown to be spatially expanding and growing progressively more severe. Hypoxic conditions on the shelf have been closely linked to the large quantities of nutrients delivered to the Gulf of Mexico via the Mississippi …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
<p>Hypoxia caused by inadequate oxygenation has profound effects on the normal functioning of the brain in mammals. Acute or chronic hypoxic insults occur in the brain depending on the duration of hypoxic exposure. Hypoxia is known to occur in the human womb and exerts adverse effects on the …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
<p>Hypoxia caused by inadequate oxygenation has profound effects on the normal functioning of the brain in mammals. Acute or chronic hypoxic insults occur in the brain depending on the duration of hypoxic exposure. Hypoxia is known to occur in the human womb and exerts adverse effects on the …
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Effects of Sickle Cell Disease on Growth of the Craniofacial Complexes
… are small at all ages, probably as a result of chronic hypoxia due to hemolytic anemia. (2) There was no discernible difference in severity between SC and SS genotypes. (3) In contrast, females regardless of genotype typically were more severely affected than males. (4) Children became …
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Effect of nicotine and alcohol exposure in utero on vascular intima medial thickness, endothelial function, and the development of cardiometabolic risk factors in children in a low-income setting.
… and alcohol such as oxidative stress, induced by chronic hypoxia in utero which affects nitric oxide (NO) bioavailability in the vascular endothelium. Aim: The aim of this study is to determine the effect of in utero exposure to nicotine and alcohol on vascular structure and function, and the …
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Development of small-molecule probes for photoacoustic imaging of hypoxia
Hypoxia occurs when tissue oxygen supply is restricted, inhibiting normal physiological processes. Because of the irregular vasculature of rapidly growing tumors, hypoxia is a hallmark of cancer and exists in 50-60% of solid tumors. Hypoxia-induced changes in gene expression lead to treatment …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… and local factors to maintain homeostasis. Hypoxia stimulates capillary angiogenesis to effectively match metabolic demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic …
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Identification of potential drug targets in glioblastoma using proteogenomic platforms
… located inside the tumour mass characterised by hypoxia, acidic stress, and/or glucose restriction. Hypoxia has been shown to promote a stem-like state in tumour cells by activating pro-migratory and pro-invasive factors. Therefore, modulating its mechanisms could contribute to the development of …
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Preeclampsia Link to Gestational Hypoxia
… uteroplacental perfusion, triggering placental hypoxia and oxidative stress. In turn, placental dysfunction is thought to be a common denominator between upstream adverse effects on the mother and downstream adverse effects on the fetus. Maternal adverse effects include the angiogenic imbalance …
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Patterns of protein expression in tissues of the killifish, Fundulus heteroclitus and Fundulus grandis
… enzymes in liver and skeletal muscle during chronic exposure (28d) of Fundulus heteroclitus. The fish was exposed to four different oxygen treatments: hyperoxia, normoxia, moderate hypoxia, and severe hypoxia. The time course of changes in maximal glycolytic enzyme specific activities was …
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