Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Chronic Constriction Injury"”.
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Über den Zusammenhang von Galaninexpression und Capsaicinempfindlichkeit in Spinalganglionneuronen von Ratten mit experimentellen Nervenverletzungen
… von Ratten mit experimenteller Axotomie oder „chronic constriction injury“ des N. ischiadicus wurden mit entsprechenden Neuronen von unverletzten Ratten unter Kulturbedingungen verglichen. Der gleichzeitige Nachweis beider Eigenschaften erfolgte in isolierten Neuronen durch eine Doppelfärbung, …
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
… side effects than other treatments. However, chronic cyclooxygenase inhibition also causes gastrointestinal inflammation and increased risk of cardiac events. Like NSAIDs, cannabinoids have analgesic and anti-inflammatory properties and reduce neuropathic pain in preclinical models. The …
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Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy.
… pain was developed by advancing the existing chronic constriction injury model. Sciatic nerve and subcutaneous chromic gut sutures were varied, resulting in ‘dose-dependent’ behavioural allodynia. Allodynia was correlated with microglial activation marker expression in the ipsilateral lumbar …
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Charakterisierung von Spinalganglienneuronen intakter und lädierter Afferenzen
… einer experimentellen Mononeuropathie (chronic constriction injury, CCI) wurde bei Ratten die Expression von Zytokinen (TNF-α, IL-10), Vanilloidrezeptor 1 (VR1) und Neuropeptiden in Spinalganglienneuronen immunhistochemisch analy-siert. Durch retrograde Anfärbung mit den Tracern …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… Using CXB-NE in rats that have peripheral nerve injury constricting the sciatic nerve relieves hypersensitivity, a pain-like behavior. The treatment also decreases inflammation associated with this chronic constriction injury (Janjic et al, 2018; Saleem et al, 2019b; Stevens et al, 2019). In this …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… we utilised an animal model of peripheral nerve injury, sciatic nerve chronic constriction injury (CCI), and 2 animal models of chemotherapy-induced peripheral neuropathy (CIPN). The immune profile of the meninges, CP, and lymphoid tissue was compared across male and female mice in acute stages …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
… noxious probes. Rats with a thoracic spinal cord injury (SCI), lumbar spinal nerve transection, or chronic constriction injury of the sciatic nerve, as well as their sham controls, exhibited heightened pain-avoidance behavior compared to uninjured controls. These findings have important …
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The role of potassium buffering and apoptosis of trigeminal satellite glial cells in the induction and maintenance of orofacial neuropathic pain in rats
… vivo endpoints were evaluated after performing chronic constriction injury (CCI) of the infraorbital nerve (IoN). NP signs and behavior were evaluated at 5, 10, 20 40 and 80 hours after injury. We evaluated the potassium buffering capacity of SGC by measuring the intracellular potassium …
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Charakterisierung von IL-4 Knockout-Mäusen und ihrer Zytokin- und Opioidrezeptor-Expression im peripheren und zentralen Nervensystem
… einer experimentellen Mononeuropathie (engl. chronic constriction injury, CCI) untersucht. Zentrale Fragestellung der Studie war, ob IL-4 knockout(ko)-Mäuse im Vergleich zu Wildtyp(wt)-Mäusen mit einem gesteigerten Schmerzverhalten sowie einer veränderten Zytokinantwort und …
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Mechanisms Underlying Chronic Pain
… on duration, pain is categorized as acute and chronic pain. Acute pain is a short-term phenomenon that resolves after the noxious stimulus is removed or the injury is healed. On the other hand, chronic pain is a long-lasting debilitating condition. In a substantial number of cases, acute pain …
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Schmerzhafte Mononeuropathie an C57BL/6 Mäusen: Studien mit neutralisierenden Antikörpern gegen Tumor-Nekrose-Faktor Alpha an zwei verschiedenen Läsionsmodellen
Die vorliegende Arbeit befaßt sich mit zwei Modellen einer schmerzhaften Mononeuropathie an der C57BL/6-Maus sowie deren Beeinflussung durch neutralisierende AK gegen TNF. Dafür wurden die Nn. ischiadici der Mäuse operativ manipuliert, zum einen in Form der CCI durch drei den Nerven einschnürende …
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Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
… stress triggering adaptive responses, whereas chronic stress and chronic neuropathic pain lead to persistent alterations in neural circuits regulating affective and sensory processing. These processes are tightly interlinked at multiple levels, and prolonged nociceptive states can induce …
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Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
… impact, the management of pain, particularly chronic pain remains a significant challenge. Current treatments often provide insufficient relief, and only a limited number of findings from basic research have successfully translated into effective therapies. This translational gap underscores …