Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Chromosome dynamics"”.
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Chromosome dynamics of the early meiotic cell cycle in S. cerevisiae
… to produce haploid progeny. The reduction in chromosome number obtained during meiosis requires specialized mechanisms that are absent during the canonical mitotic cell cycle. Although previous studies found strong similarities between pre-mitotic and pre-meiotic DNA replication, pre-meiotic S …
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Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes.
… that they are preferentially anchored to human chromosomes at sites adjacent to the telomeres, resulting in a random segregation pattern of DMs to post-mitotic neuroblastoma cells. Furthermore, by making human/murine hybrids we showed that DMs do not bind to specific positional elements in human …
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Chromosome dynamics during cell divisions in Drosophila melanogaster: The role of Rad21 in meiotic cohesion and dynamic analysis of the condensin subunit CapG in early embryonic mitotic divisions
… regions. The compaction process is known as chromosome condensation, which is a prerequisite for accurate segregation of sister chromatids in anaphase. Chromosome condensation and sister chromatid cohesion require multisubunit protein complexes, the condensin and the cohesin complexes, …
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Regulation of meiosis I chromosome segregation by Spol3 and Cdc5 in Saccharomyces cerevisiae
… to the next generation. The reduction of chromosome number by half is brought about two chromosome segregation phases following a single DNA replication phase. In the first division, homologs segregate away from each other and in the second division the sister chromatids separate. These …
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Mitotic Dynamics of Normally and Mis-attached Chromosomes and Post-mitotic Behavior of Missegregated Chromosomes
… that assemble on each chromatid of each mitotic chromosome. By combining computational modeling and quantitative light microscopy, we established a quantitative model of the forces and regulators controlling metaphase chromosome movement in the mammalian cell line derived from Potorous …
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Characterization of the DNA repair role of the Saccharomyces cerevisiae NSE1 gene
In eukaryotes, the structural maintenance of chromosomes (SMC) complexes play important roles in chromosome dynamics. The Saccharomyces cerevisiae Smc5-Smc6 complex is composed of eight essential subunits and is particularly required for a normal response to DNA damage. Hypomorphic mutations in …
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Analysis of the Nucleioprotein Complexes Essential for P1 Plasmid Partition
… plasmids. Low-copy-number plasmids and bacterial chromosomes encode active partition systems to ensure their inheritance within a bacterial cell population. One of the well-studied models of partition is that of the P1 plasmid in E. coli. The partition system encoded by the P1 plasmid is known as …
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Studies of Aurora and Polo Kinases During Cell Division in C. elegans
Accurate chromosome segregation during cell division requires the precisely regulated release of chromosome cohesion. In mitosis, sister chromatids are linked by chromosome cohesion until the proteolysis of the cohesion Scc1 by separase triggers the separation of sister chromatids at anaphase. …
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Mechanistic Insights into the Microtubule-Mediated Differential Modulations of Aurora B Substrate Structures for Accurate Chromosome Segregation
<p>Faithful chromosome segregation during eukaryotic cell division depends on the ability of sister kinetochores on duplicated chromatids to attach microtubules from opposite spindle poles. Failure in this process causes aneuploidy and drives cancer formation. To maintain genomic integrity, …