Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Chromosome Conformation Capture (3C)"”.
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Patterns and processes driving chromosome organization
… analysis of interaction maps generated from Chromosome Conformation Capture (3C) technologies. We begin by analyzing data generated using a novel Micro-C protocol and assess its performance in comparison to established Hi-C. New computation tools are developed to extract, quantify and compare …
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Computational Analysis of Transcriptional Regulation
… for early cervical carcinogenesis with a novel Chromosome Conformation Capture (3C) method that specifically enriches for interactions involving viral integrants. Integration occurs without disrupting host 3D chromatin structure but alters the expression of many neighbouring host genes. The …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
… gene regulation. At the very largest scales, chromosomes are known to occupy distinct chromosome territories, intermingling only at the borders. At the very smallest scale, chromatin is known to be organised into a beads on a string like structure of nucleosomes. Until the advent of Chromosome …
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Transcript Regulation within the Kcnq1 Domain
… that distinguish the maternal from the paternal chromosomes in the form of methylation. Methylation marks can influence transcript expression, resulting in only one allele being expressed. One imprinted domain is the Kcnq1 domain located on chromosome 11p15.5 in humans and chromosome 7 in the …
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The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription
Nukleare Hormonrezeptoren (NHRs) sind Liganden-abhängige Transkriptionsfaktoren mit breitem physiologischem sowie pathophysiologischem Funktionsspektrum. Molekulare Therapien die sich gegen NHRs richten, stellen eine optimale Behandlung einiger humaner Krankheiten dar. Der Östrogenrezeptor ist …