Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Chromosomal structure"”.
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Study of meiotic chromosomal structure and molecular mechanisms of meiotic prophase I
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Transposable prophage Mu exists as an independent chromosomal domain in E. coli
… was observed at two structurally different chromosomal locations, and was specific to the Mu prophage, i.e. was not observed for the [mathematical symbol] prophage. A model is proposed that by employing its cis-elements to create a domain barrier for segregation and compaction of its genome, …
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The Regulation of Dna Methylation In Mammalian Development and Cancer
… such as gene transcription, maintenance of chromosomal structure and genomic stability, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Dysregulation of DNA methylation is associated with various human diseases. For example, cancer cells usually show global …
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Development and application of a general method for somatic cell genetics
… drivers, paralogous gene expression pattern, and chromosomal structure. By mapping sets of genes displaying variable but correlated essentiality across lines, I uncovered functionally interacting gene networks. Using this dataset, I also identified genetic vulnerabilities associated with oncogenic …
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Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair
… responses. DNA context is important; cell cycle, chromosomal structure, and sequence all can make DSBs more likely or more problematic to repair. Saccharomyces cerevisiae is very resilient to DSBs and primarily uses a process called homologous recombination to repair DNA damage. To further our …