Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Chromosomal instability"”.
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Mechanisms of Palindrome-Mediated Chromosomal Instability
… are highly unstable DNA sequences that induce chromosomal rearrangements and underlie cancer and hereditary diseases such as Emanuel Syndrome. Despite being a significant source of genomic instability, the mechanisms governing palindrome fragility in eukaryotic cells are not fully defined. In …
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Signatures of chromosomal instability in human cancers
Chromosomal instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the …
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
<p>Telomere dysfunction drives chromosomal instability (CIN) during the transition from benign adenoma to malignant adenocarcinoma. While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with …
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Constitutively active-RSK2 induces chromosomal instability through diverse mechanisms
… loss and/or gain of single chromosomes through chromosomal instability may be the most common pathway to aneuploidy. We observed that constitutively acvtive RSK2 induced chromosomal instability such as lagging chromosome and chromosome bridge, micro-nucleus and abnormal number of chromosome. …
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Targeting chromosomal instability: screening and characterization of CIN killers.
Chromosomal INstability (CIN), a hallmark of cancer cells, refers to a state in which cells have an increased rate of gain or loss of whole chromosomes or large chromosomal fractions. CIN is linked to the progression of tumours with poor clinical outcomes such as drug resistance and metastasis. …
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Measuring ongoing chromosomal instability in single-cell DNA sequencing data
Chromosomal instability is a characteristic hallmark of cancer. It is providing part of the genomic variation that makes cancer so heterogeneous and difficult to treat. Consequently, better insights into the mechanism and dynamics of chromosomal instability are fundamental to understanding and …
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Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… of the mammalian spindle checkpoint can cause chromosomal instability (CIN), the frequent gain or loss of entire chromosomes during cell divisions. While CIN has been proposed to be sufficient to initiate tumorigenesis, no direct evidence has shown that CIN itself is a causal agent for human …
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Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer
… likely precipitated by oestrogen-induced chromosomal instability, are recurrent in 15% of breast cancer, defines the IntClust6 subtype, and portends poor prognosis with high risk of late relapse and chemotherapy resistance. ZNF703 is the most frequently amplified gene and the putative …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
… to cell-cycle control, thereby restraining chromosomal instability, tumor evolution, and providing a therapeutically exploitable vulnerability in cancer therapy.
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Mechanical Confinement and Heat as Drivers of Aneuploidy in Cancer
… changes. In Chapter 3, I extend my studies on chromosomal instability to other stressors. Hyperthermia destabilizes the mitotic spindle, induces abnormal spindle morphologies, and produces a linear increase in heritable chromosome losses and micronuclei across multiple cancer cell lines. In …
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Role of inherited DNA repair deficiencies in cancer susceptibility and evolution
… with characteristic signatures. This genomic instability is associated with the heritability of multiple cancer syndromes. I explored the role of inherited DNA repair deficiencies in cancer predisposition, progression and evolution. Using whole genome sequencing from family trios and a …
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In Vivo Functional Significance of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome
… been shown to play an important role in inducing chromosomal instability and supporting cell proliferation and cell cycle arrest. However, a causal role of <em>CCAT2</em> in initiation of tumorigenesis and the importance of G/T SNP in <em>CCAT2</em>-induced phenotype still remains to be resolved. …
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Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… in sporadic colon cancer; one of which is chromosomal instability (CIN). One hypothesized driver of CIN in cancer is the improper repair of dysfunctional telomeres. Telomeres comprise the linear ends of chromosomes and play a dual role in cancer. Its length is maintained by the …
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Discovering GCNA: A Novel Regulator of Germline Genomic Stability
… the ability to generate variation by exchange of chromosomal segments during meiosis. During meiosis, hundreds of double-stranded DNA breaks are initiated at once, which if generated in most other cell types would introduce chromosomal aberrations. Germ cells, however, execute the formation of …
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Discovery and Elucidation of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma
<p>Fusion genes occur due to chromosomal instability where two previously separate genes rearrange and fuse together, forming a hybrid gene. The first fusions were reported in leukemias; however, with the advent of more powerful sequencing technologies, fusions have recently been reported in …
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Investigating the Relationship Between Calorie Restriction and Mitotic Protein BubR1 in the Prevention of CIN-Induced Tumorigenesis
… are complex and largely undefined. Genomic and chromosomal instability in the form of aneuploidy is a hallmark of both aging and cancer, and it is theorized that the natural age-related deregulation of important mitotic processes leads to aneuploidy that increases the risk of cancer. BubR1, an …
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