Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Chromosomal abnormalities"”.
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The human Y chromosome : gene content and chromosomal abnormalities
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Utilization of fish for constitutional and acquired chromosomal abnormalities for diagnostic and prognostic purposes
… of FISH for Constitutional and Acquired Chromosomal Abnormalities for Diagnostic and Prognostic Purposes Amy L. Shackelford Fluorescence in-situ hybridization (FISH) is a useful molecular cytogenetics technique for counting chromosomes and identifying specific chromosomal sequences of …
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A study of oral health care for the children with genetic disorder and chromosomal abnormalities
This study was performed to prepare the references of oral hygiene management for the children with Down's Syndrome and Angelman Syndrome. Thirty five caregivers of the children was answered about children`s characteristics, oral health condition and management, socio-economic status of the …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… genetic information but are limited to known abnormalities that have previously been identified with the use of cytogenetics, array comparative genomic hybridization (CGH), gene-expression profiling, and the resequencing of candidate genes. At diagnosis, most patients with AML harbour at least …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… genetic information but are limited to known abnormalities that have previously been identified with the use of cytogenetics, array comparative genomic hybridization (CGH), gene-expression profiling, and the resequencing of candidate genes. At diagnosis, most patients with AML harbour at least …
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Aneuploidy and DNA fragmentation in morphologically abnormal sperm
… between abnormal sperm morphology and chromosomal abnormalities has been suggested but not been conclusive and less is known about the connection between sperm morphology and DNA integrity. Sperm morphology will be evaluated on its ability to identify the level of chromosomal …
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Κυτταρογενετική μελέτη των κακοηθών λεμφωμάτων της παιδικής ηλικίας
… cases of Hodgkin's disease. 13 patients showed chromosomal abnormalities and three patients had normal karyotype. In these 13 patients, 16 structural atypias were identified. From these, 9 were chromosomal translocations, from which three were translocation t(14;18) (q32;q21), one t(8;14) …
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Selenium levels and recurrent pregnancy loss : is there an association?
… for RPL have been documented and these include chromosomal abnormalities, peas, thrombophilias and anatomical anomalies such as cervical incompetence. In many couples the aetiology of the pregnancy loss is often not defined but nutritional deficiencies have been postulated as possible causes. In …
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Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… diverse and nearly 50% of patients present with chromosomal abnormalities. Deletion of the short arm on chromosome 17 (del17p) occurs in 5-7% of cases and presents with the shortest median survival time and often respond poorly to therapy. The tumor suppressor gene, TP53 is located on this region …
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The role of recombinational repair in the mechanism of killing during thymine starvation in Escherichia coli
… cells were observed to accumulate chromosomal breaks and induce the SOS response, indicating chromosomal damages, but it is unclear if the chromosomal damage is the cause of lethality. The goal of this work is to elucidate the mechanism of thymineless death, by investigating if the …
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Human subtelomeric aberrations in the Hong Kong population
… environmental, or a combination of both. Chromosomal abnormalities are a major cause of ID. They are more commonly seen in patients with moderate-severe ID than in patients with mild ID, accounting for up to 40-50% of these cases. Subtelomeric aberrations constitute an important subset of …
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TOWARDS AN UNDERSTANDING OF GENETIC SELECTION IN BREAST CANCER
Cancer genomes accumulate chromosomal abnormalities and gene mutations but must maintain the ability to survive in vitro. We sought evidence in breast cancer that genetic selection acts to maintain tumour survival. Analysis of genomes from 243 breast tumours revealed 766 unstable and 812 stable …
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Genetic analysis of squamous cell carcinoma of the head and neck
… would benefit from a greater insight into the chromosomal alterations underlying the disease. Knowledge of such alterations would be expected to provide many benefits to the HNSCC clinician in terms of diagnostic and prognostic markers and may eventually identify novel molecular targets for …
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A chromosomal analysis of 25-day pig embryos
… Hampshire boars to produce 25-day embryos for chromosomal analysis. Blood samples were drawn from five of these gilts and one of the boars for leucocyte cultures and a comparison was made between karyotypes prepared from the dam with those prepared from her 25-day embryos. The mean ovulation …
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Chromosome identification and analysis in selected lines of laboratory mice
… Karyotypes for each line were made with no chromosomal abnormalities detected in any of the lines. The selection regime followed has produced significant genetic change in several characteristics of these mice. However, these changes have apparently not been accompanied by observable …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
… a dose dependent increase in the DNA damage and chromosomal abnormalities in all tested groups regardless of confounding factors. Prior to experiments physicochemical characterisation of nanoparticles was conducted. In the presence of the flavonoids, quercetin and rutin that were acting in an …
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Genetic basis of hereditary persistence of fetal haemoglobin
… was investigated. Birth weight, gestation and chromosomal abnormalities were not responsible and the frequency of the 4.9kb g-thalassaemia deletion mutation was determined to be low.
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Machine Learning Techniques for Augmenting Hematological Malignancy Diagnosis
… for clinically informative recurring structural chromosomal abnormalities and serving as a clinical decision support system for clinical MFC data analysis. Most of the data used for this work are from patients with acute myeloid leukemia, but these ML algorithms can easily be extended to other …
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Effect of Anchoring On Perceived Amniocentesis Related Miscarriage Risk Within A Latina Population
… of prenatal diagnostic test, is used to detect chromosomal abnormalities, such as Down syndrome. Amniocentesis is associated with a risk of complications that can lead to a miscarriage, which is typically quoted to be between 1 in 300 and 1 in 500. Amniocentesis uptake rates are typically lowest …
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