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Showing 1 to 9 of 9 for “"Chromene"”.
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NEW GREEN TECHNOLOGIES FOR ORGANOCATALYTIC ASYMMETRIC EPOXIDATION APPLICATIONS IN SYNTHESIS
… of asymmetric epoxidation reactions on chromene substrates mediated by Page’s iminium salt catalysts. Organocatalytic asymmetric epoxidation is an efficient tool to access enantiomerically rich epoxides. This study is divided into three main parts which are discussed in each chapter. The …
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Some chemistry of bromobenzopyrans
… of the resulting chroman-4-ols gave the 2H-chromenes in excellent yield. Addition of N-bromosuccinimide in moist dimethyl sulfoxide to the 2H-chromenes gave the trans-3-bromochroman-4-ols in good yield. Subsequent dehydration using a catalytic amount of 4-toluenesulfonic acid in refluxing …
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Synthetic studies and biological evaluation of chromone - 3 - carbaldehydes
… followed by the oxidation thereof to 4-oxo-4H-chromene-3-carboxylic acids. A series of chromone-3-carboxamides was obtained from corresponding 4-oxo-4H-chromene-3-carboxylic acid via the in situ generation of the corresponding acid chloride in good yield. The second class of compounds were …
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SÍNTESE DE NOVOS DERIVADOS DE LAPACHONAS E NOR-LAPACHONAS: VEREDAS À ATIVIDADE FARMACOLÓGICA
… 4-azido-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10- dione (86) and 3-azido-2,2-dimethyl-2,3-dihydro-naphtho[2,3-b]furan-4,9-dione (93). The orto-furan-naphthoquinones 3-[4-(1-hydroxy-cyclohexyl)-[1,2,3]triazol-1-yl]-2,2- dimethyl-2,3-dihydro-naphtho[1,2-b]furan-4,5-dione (80), …
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RECENT ADVANCES IN IMINIUM SALT CATALYSED ASYMMETRIC EPOXIDATION
… as a tool in the kinetic resolution of racemic chromene substrates, and (ii) investigations into the asymmetric epoxidation of new N-protected dihydroquinoline substrates. In the first part of chapter two, the first examples of kinetic resolution in epoxidation reactions using iminium salt …
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The application of organocatalytic Asymmetric Epoxidation
… has been successfully employed to access chiral chromenes within the Page group. Iminium-catalysed asymmetric epoxidation methodology has been applied to the synthesis of levcromakalim, 3 trans-khellactone, and lomatin,4 which are based on a chromene-type structure. In this thesis, we offer a …
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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
… molecules; tetrahydroisoquinoline (THIQ) and chromenes. These molecules were screened in vitro to find the most potent anticancer derivatives that exhibited the least toxicity on normal stromal cells. EDL-360 (5-10 µM) and SP-6-27 (IC50 = 7-21 nM) were the most potent analogs of THIQ and …
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Some chemistry of chromenes and chromanones
… chroman-4-ols yielded the corresponding chromenes. The established synthesis of chromenes involving the rearrangement of aryl propargyl ethers has been modified such that the chromene can be prepared directly by reaction of an alkynol with a suitably activated phenol at an alumina …
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Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants
As a part of the continuing search for bioactive compounds with the Madagascar International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), thirteen plant extracts were investigated …