Global ETD Search
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Showing 1 to 20 of 25 for “"Chromatin remodelers"”.
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
Chromatin is highly regulated nucleoprotein complex facilitating the dynamic balance between genome packaging and accessibility. The central workhorses regulating the dynamic nature of chromatin are ATP-dependent chromatin remodelers- ISWI, SWI/SNF, INO80, and CHD/Mi2. All chromatin remodelers …
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THE MECHANISMS OF ISW1A, ISW1B AND ISW2 CHROMATIN REMODELERS
The focus of this study was to understand the nucleosome remodeling mechanism of three ISWI complexes in yeast using various biochemical approaches. The aspects investigated were, identification of the suitable substrate for ISW1a, role of accessory subunits and various domains/motifs of ISWI …
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CHD Chromatin Remodelers Promote Epigenetic Control of Development in Arabidopsis thaliana
Chromatin remodeling is a vital biological process that facilitates activation and repression of gene expression as well as compaction of large eukaryotic genomes into compact nuclei. The CHD3 family of chromatin remodelers play key roles as epigenetic modifiers and transcriptional regulators in …
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DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION
… TITLE: DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION MAJOR PROFESSOR: Dr. Blaine Bartholomew Chromatin remodelers are conserved from yeast to humans and are the gatekeepers of chromatin. They regulate transcription by …
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MODES OF NUCLEOSOME INTERACTION AND MECHANISMS OF THE SACCHAROMYCES CEREVISIAE CHROMATIN REMODELERS INO80 AND ISW1A
The dynamic nature of eukaryotic chromatin enables the packaging of large amounts of genetic material in a small space. At the same time, it provides controlled access to genomic DNA for a variety of nuclear processes for example, transcription and DNA repair. The transition between open and closed …
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Analysis of CHD Remodelers during Development: A Tale in Two Organisms
… Organisms have recruited ATP-dependent chromatin remodelers to ensure the correct timing of gene expression during developmental transitions. Here I show how different CHD ATP-dependent chromatin remodelers regulate developmental transitions of different organisms. I show that PICKLE not …
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THE INTERPLAY OF HISTONE CHAPERONE NAP1 WITH SWI/SNF FAMILY OF CHROMATIN REMODELLERS IN S.cerevisiae
… one of the mechanisms by which the ATP dependent chromatin remodelers remodel the nucleosomes. However nucleosome remodeling is also regulated by other factors like covalent modifications marks (methylation, acetylation etc. of both histones and chromatin remodelers). and histone chaperones. All …
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The Regulation of the Phosphatidate Phosphatase Gene <em>PAH1</em> and Its Regulatory Role on Cell Homeostasis
… were subsequently used to help determine the chromatin remodelers involved in <em>PAH1</em> gene expression. Chromatin remodelers play a significant role in modifying and restructuring the nucleosome and therefore play an essential role in the regulation of gene expression. Using growth curve …
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Statistical analysis and modeling of nucleosome positioning
… is the fundamental building block of eukaryotic chromatin. The precise location of nucleosome along the genome plays a central role in gene regulation by controlling the accessibility of genetic information encoded in DNA. Understanding the principles underlying the establishment of genome-wide …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… interactions between FUS-CHOP and multiple chromatin remodeling complexes via co-IP including a new interaction with SNF2H, the ATPase subunit of the imitation switch (ISWI) complex. Using knockdown systems, we demonstrated that these interacting chromatin remodelers are functionally …
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Highly Constrained Kinetic Models for Quantitative Single-Cell Gene Expression Analysis
… followed by recruitment of proteins like chromatin remodelers, general transcription factors, and RNA polymerase II in eukaryotes. Variability in transcriptional outcomes arises from both regulatory mechanisms and stochastic events, making it essential to understand transcription dynamics …
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Chromatin Dynamics During DNA Replication
The primary level of chromatin organisation consists of arrays of nucleosomes that are present across the genetic template. Advances in the post genomics era have made it possible to determine the positions of nucleosomes genome-wide where it has been observed that nucleosomes adopt a distinct …
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Mechanisms underlying cell-to-cell diversity in clonal populations of yeast
… with downstream DNA binding factors and chromatin remodelers. The genes regulated by these promoters encode cell-surface glycoproteins that mediate a range of cell-to-cell and cell-to-surface adhesions. Phenotypic diversity in clonal populations of yeast cells is mediated in part by …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… nuclear receptors, their coregulators and chromatin remodelers. This screen identified RUVBL1 and RUVBL2 (collectively referred to as RUVBL1/2) as differentially required for the viability of NSCLC. We show that RUVBL1/2 require their ATPase activity to support NSCLC viability and have …
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ROLES OF ACCESSORY DOMAINS IN THE CATALYTIC SUBUNIT OF ISW2
Regulation of chromatin structures in eukaryotes involves ATP-dependent chromatin remodeler complexes. ISW2 belongs to the ISWI family of chromatin remodelers in Saccharomyces cerevisiae and has been shown to be involved in transcription repression and DNA replication. The catalytic subunit of ISW2 …
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AN INSIGHT INTO DIFFERENT MODES OF REMODELER REGULATION: FOCUS ON SACCHAROMYCES CEREVISIAE SWI/SNF
ATP dependent chromatin remodelers use the energy from ATP hydrolysis to move, disassemble or alter the composition of nucleosomes. Though all remodelers share a conserved ATP hydrolysis and DNA translocase domain, their biochemical actions and in-vivo characteristics differ because of their …
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STRUCTURAL AND FUNCTIONAL DELINEATION OF SUBUNITS AND DOMAINS IN THE SACCHAROMYCES CEREVISIAE SWI/SNF COMPLEX
Chromatin remodelers are ATP-dependent multisubunit assemblies that regulate transcription and other processes by altering DNA-histone contacts. The mechanism of action is based on the transduction of energy released by ATP hydrolysis to translocation on DNA and ultimately the movement of histones …
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Licensing Of Cell Fate Reprogramming Via Leafy Transcription Factor Pioneering Activity
… during cell fate reprogramming in the context of chromatin. A special class of transcription factors, termed pioneer transcription factors, is ideally suited to execute this role because they can bind their target sites in nucleosomes. Although plants frequently reprogram cell fate in response to …
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SWI/SNF COMPLEXES COORDINATE WITH HISTONE MODIFICATIONS TO REGULATE CHROMATIN REMODELING
SWI/SNF, the founding member of ATP dependent chromatin remodelers and its paralog RSC in yeast perform similar yet distinct functions inside the cell. In vitro these complexes use ATP dependent DNA translocation to either mobilize or disassemble nucleosomes. However, how these complexes interact …
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Characterization of the p23 interaction network
… sizeable nuclear network were six subunits of chromatin remodelers, accounting for five of the eight complexes present in Saccharomyces cerevisiae. Given the recent finding that p23 deletion alters global chromatin states (Zelin et al. 2012), we sought to study p23 functions with chromatin …
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