Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Chromatin decondensation"”.
-
Analysis of Human Sperm Chromatin Integrity
… material in the two condensation stages of chromatin and chromosomes. Original semen samples (ORI) and their swim-up fractions (SW, selected for motility) from men of known (donors) and unknown (patients) fertility were analyzed. The extent of chromatin condensation was assessed by light …
-
Early and late events in NET formation
… traps) – networks of extruded decondensed chromatin adorned with antimicrobial molecules, which primarily serve to immobilize and inactivate pathogens (bacteria, viruses, yeasts, and fungi). In addition, it has been widely reported that NETs play a role in the progression of various …
-
A histone H4 code regulates 53BP1-mediated responses to DNA damage
… that combinations of modifications regulate chromatin processes differently than modifications occurring individually. However, surprisingly little is known about the nature and functions of multi-site histone modification. This study investigates functional interactions between acetylation …
-
Role of ORCA/LRWD1 in the maintenance of telomere integrity
… by the coordination of replication, heterochromatin, and DNA damage repair machinery. In this thesis, I describe how Origin Recognition Complex-associated (ORCA/LRWD1), regulates telomere integrity in Alternative Lengthening of Telomeres (ALT) -positive cells. In the absence of Telomere …
-
Role of ORCA and ORC in chromatin organization and DNA replication
… or individual subunits of ORC including heterochromatin organization, telomere and centromere function, centrosome duplication and cytokinesis. Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases …
-
Genomic and microscopic dissection of nuclear compartmentalization and function
… transcriptionally active and inactive chromatin positioned at the interior and periphery of the nucleus, respectively. Newer genomic methods (SPRITE, GAM) suggest multi-way interactions occurring more frequently in the nuclear interior, specifically at nucleoli and nuclear speckles. But …