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Showing 1 to 20 of 36 for “"Choroid plexus"”.
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Bispecific Ligand Conjugate Immunotherapy of Choroid Plexus Brain Tumors
This work may offer insights into the application of bispecific ligand conjugates to the treatment of human cancers. Application of this design includes all tumors that express folate receptors, but additional ligands may be used to target other tumor varieties.
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Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish
<p>The choroid plexus (CP) is an epithelial based structure localized within the brain ventricles and functions as the blood-cerebrospinal fluid barrier (BCSFB). Under normal conditions, the CP is responsible for generating the cerebrospinal fluid (CSF) and regulating its components. Abnormal CP …
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Functional and Molecular Aspects of Xenobiotic Transport in Choroid Plexus
The choroid plexus (CP) epithelium forms the blood-cerebrospinal fluid (CSF) barrier, which along with the blood-brain barrier (BBB) capillary endothelium maintains the fluid environment of the brain. The CP not only secretes CSF, but also transports potentially toxic xenobiotics and waste products …
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Developmental Characterization of the Choroid Plexus in Sialidosis (Neu1 Deficient) Mice
… an intrinsic exocytic/endocytic capacity: the choroid plexus (CP). The CP is responsible for producing and secreting the cerebrospinal fluid (CSF) and functions as the barrier interface between the blood and the CSF. The specific aim of this research was to investigate the consequences of Neu1 …
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The Ultrastructure of the Choroid Plexus in Vitamin A Deficient Rabbits
<p>The fire structure of the lateral choroid plexus in vitamin A deficient hydrocephalic New Zealand white rabbits has been studied with the aid of both light and electron microscopy.</p> <p>A special Vitamin A deficient diet was fed to all rabbits and control rabbits in addition received orally …
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The Comparative Ultrastructure of the Choroid Plexus in Certain Animal Species
… the writer studied the ultra-structure of the choroid plexus of the lateral and the 4th ventricles of the brain in seven species of animals comparatively. No such extensive comparative investigation has been made before with this instrument. The animals represent, in the main, species which …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
… of immunotherapies against endogenously arising choroid plexus tumors. The model we use is the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We found that systemic administration of the proinflammatory TH1 cytokine, …
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TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production
… CSF is produced primarily by the choroid plexus (CP), found in the ventricles of the brain. Composed of a high resistance epithelium surrounding a capillary network, the CP epithelium acts as a barrier, regulating ion transport between the CSF and blood. Transient Receptor …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought to only produce cerebrospinal fluid. Advances have dispelled these limited views, and the meninges and CP are now known as critical sites of immune activity, housing various immune cells, including B and T cells, …
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Regionalized choroid plexus-cerebrospinal fluid factors and effect of DNA Ligase IV deficiency in the developing mammalian brain
… extrinsic cues during brain development. The choroid plexus, a highly vascularized tissue located in each ventricle of the brain, actively secretes cerebrospinal fluid. By RNA sequencing, we obtained transcriptome data on the choroid plexi from lateral and fourth ventricles of the mouse brain …
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Developmental Expression of Rat Target of the Antiproliferative Antibody (rTAPA) Protein in the Brain
… brain. This protein is expressed by ependyma, choroid plexus, astrocytes, and oligodendrocytes, and rTAPA is dramatically upregulated at the time of glial birth and maturation. At embryonic day 18, the levels of rTAPA are low, with most of the immunoreaction product associated with the …
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Establishing a positional information assay for brain ventricle mutants and investigating the choroid plexuses in zebrafish
… In addition, I have investigated the choroid plexus (CP) cells lining the brain ventricles in the zebrafish. Though we were unable to clearly identify the CP in the adult brain, we did identify two homologues in zebrafish of a conserved gene expressed in CP of vertebrates. We found …
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Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin
… exact molecular mechanisms remain unknown. The choroid plexus, which produces the CSF, is adjacent to the origin of IVH and is the first organ to encounter the extravasated blood. The subsequent haemolysis of red blood cells causes release of cell-free haemoglobin (Hb), which will with time …
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Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
… in children with adrenocortical tumors, choroid plexus tumors and early childhood rhabdomyosarcomas and investigate whether these may be early manifestations of Li-Fraumeni syndrome (LFS). Germline TP53 mutations were found in few children with adrenocortical tumors and rhabdomyosarcomas. …
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Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
… penetrance occurred across neurovasculature, choroid plexus, and circumventricular organs (CVOs). Treatment with the AQP4 inhibitor, AER-271, blocked tracer passage across the glia limitans and caused tracer accumulation within perivascular spaces. These data show that AQP4 mediates the flux …
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Tissue Parameter Mapping in Children with Fetal Alcohol Spectrum Disorders
… cortex, hippocampus, accumbens, putamen, choroid plexus, ventral diencephalon (DC), right vessel and ventricles. Significant T2 differences were found in the caudate, brain stem, corpus callosum (CC), amygdala, cerebral cortex, choroid plexus, vessels and ventricles. Significant T2* …
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Obesity, 11β-hydroxysteroid dehydrogenase and metabolic changes in the pathogenesis of idiopathic intracranial hypertension
… We demonstrated that ICP regulating structures (choroid plexus and arachnoid granulation tissue), are potential glucocorticoid target tissues expressing 11β-HSD1. Metabolomic analysis identified a unique biofluid metabolite biomarker profile, with potential implications for IIH pathogenesis. We …
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The role of the gut microbiota in the function and integrity of brain barriers
… the tight junction protein networks in isolated choroid plexus tissue. Similar assessment of the choroid plexus capillaries revealed no difference between germ-free and conventional mice. Since microbial metabolites are some of the known contributing factors of the gut microbiota’s manipulation …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
… as well as increased CD4+ T-cells in the choroid plexus. Finally, we observed immunosurveillance of the brain by T-cells and CD45highCD11b+ cells in C57BL/6 mice after influenza inoculation. This immunosurveillance could prove detrimental to MS patients.
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… treatment strategies without brain surgery. Choroid plexus epithelial cells (CPEC) are responsible for production of cerebrospinal fluid (CSF). Ependymal cells line the ventricles and play roles in CSF maintenance and waste clearance. Astrocytes perform various functions, one being …
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