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Showing 1 to 20 of 61 for “"Choroid"”.
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The Multifunctional Melanocortin System in the Human Choroid
The choroid is a vascular pigmented tissue in the eye located between the outer collagenous sclera and inner neural retina. The choroid stroma includes extracellular matrix, blood vessels, immune cells, nerves, fibroblasts, and melanocytes. As one of the most abundant cells within the choroid, …
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Bispecific Ligand Conjugate Immunotherapy of Choroid Plexus Brain Tumors
This work may offer insights into the application of bispecific ligand conjugates to the treatment of human cancers. Application of this design includes all tumors that express folate receptors, but additional ligands may be used to target other tumor varieties.
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Optical frequency domain imaging of human retina and choroid
… problem, they are inadequate for imaging the choroid, which can be useful for evaluating choroidal disorders as well as early stages of retinal diseases. The objective of this thesis was to develop a new ophthalmic imaging method, termed optical frequency domain imaging (OFDI), to overcome …
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Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish
<p>The choroid plexus (CP) is an epithelial based structure localized within the brain ventricles and functions as the blood-cerebrospinal fluid barrier (BCSFB). Under normal conditions, the CP is responsible for generating the cerebrospinal fluid (CSF) and regulating its components. Abnormal CP …
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Functional and Molecular Aspects of Xenobiotic Transport in Choroid Plexus
The choroid plexus (CP) epithelium forms the blood-cerebrospinal fluid (CSF) barrier, which along with the blood-brain barrier (BBB) capillary endothelium maintains the fluid environment of the brain. The CP not only secretes CSF, but also transports potentially toxic xenobiotics and waste products …
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Developmental Characterization of the Choroid Plexus in Sialidosis (Neu1 Deficient) Mice
… an intrinsic exocytic/endocytic capacity: the choroid plexus (CP). The CP is responsible for producing and secreting the cerebrospinal fluid (CSF) and functions as the barrier interface between the blood and the CSF. The specific aim of this research was to investigate the consequences of Neu1 …
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The Ultrastructure of the Choroid Plexus in Vitamin A Deficient Rabbits
<p>The fire structure of the lateral choroid plexus in vitamin A deficient hydrocephalic New Zealand white rabbits has been studied with the aid of both light and electron microscopy.</p> <p>A special Vitamin A deficient diet was fed to all rabbits and control rabbits in addition received orally …
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The Comparative Ultrastructure of the Choroid Plexus in Certain Animal Species
… the writer studied the ultra-structure of the choroid plexus of the lateral and the 4th ventricles of the brain in seven species of animals comparatively. No such extensive comparative investigation has been made before with this instrument. The animals represent, in the main, species which …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
… of immunotherapies against endogenously arising choroid plexus tumors. The model we use is the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We found that systemic administration of the proinflammatory TH1 cytokine, …
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TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production
… CSF is produced primarily by the choroid plexus (CP), found in the ventricles of the brain. Composed of a high resistance epithelium surrounding a capillary network, the CP epithelium acts as a barrier, regulating ion transport between the CSF and blood. Transient Receptor …
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Physiological responses of human retina and choroid to retinal image defocus: Implications for myopia
… local regulation of eye growth. The retina and choroid have been implicated in detecting defocus and relaying information to the sclera to control eye size and thus maintain emmetropia. However, the mechanisms underlying retinal and choroidal responses to defocus remain unclear. Aims: To …
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Establishing a positional information assay for brain ventricle mutants and investigating the choroid plexuses in zebrafish
… In addition, I have investigated the choroid plexus (CP) cells lining the brain ventricles in the zebrafish. Though we were unable to clearly identify the CP in the adult brain, we did identify two homologues in zebrafish of a conserved gene expressed in CP of vertebrates. We found …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought to only produce cerebrospinal fluid. Advances have dispelled these limited views, and the meninges and CP are now known as critical sites of immune activity, housing various immune cells, including B and T cells, …
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Regionalized choroid plexus-cerebrospinal fluid factors and effect of DNA Ligase IV deficiency in the developing mammalian brain
… extrinsic cues during brain development. The choroid plexus, a highly vascularized tissue located in each ventricle of the brain, actively secretes cerebrospinal fluid. By RNA sequencing, we obtained transcriptome data on the choroid plexi from lateral and fourth ventricles of the mouse brain …
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Targeted drug delivery within the eye
… of pharmacotherapies to cornea, ciliary body, choroid, and posterior segment of the eye using microneedles as a drug delivery platform. The first part of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal …
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Developmental Expression of Rat Target of the Antiproliferative Antibody (rTAPA) Protein in the Brain
… brain. This protein is expressed by ependyma, choroid plexus, astrocytes, and oligodendrocytes, and rTAPA is dramatically upregulated at the time of glial birth and maturation. At embryonic day 18, the levels of rTAPA are low, with most of the immunoreaction product associated with the …
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Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin
… exact molecular mechanisms remain unknown. The choroid plexus, which produces the CSF, is adjacent to the origin of IVH and is the first organ to encounter the extravasated blood. The subsequent haemolysis of red blood cells causes release of cell-free haemoglobin (Hb), which will with time …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… circulation from both the conjunctival and choroidal blood vessels and lymphatics, iv thus overcoming the dynamic barrier. Moreover, this pathway might overcome the major drawback associated with steroid therapy (glaucoma and cataract), since a trans-scleral route of absorption is accessed. …
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Design of a Precision Needle for Injection of Fluid into the Suprachoroidal Space of the Eye for the Treatment of Retinal Detachment
… distorted vision upon recovery. In-office Suprachoroidal Viscopexy™ (SCVEXY™) is a minimally invasive technique recently developed by Dr. Rajeev Muni for treating rhegmatogenous retinal detachment (RRD) which has been performed on a handful of people [2]. This procedure has the potential to …
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Record and analysis with conclusions upon the examination of 1,041 school children attending the Bradford Eye and Ear Hospital, from April 1902 to November 1905
… and simple, or to a diseased condition of the Choroid etc: Personally I think it is due to a combination of both of these conditions, although the: strain certainly plays a very important part.
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