Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Chondroprotective"”.
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Osteoarthritis: the role and mechanisms of the chondroprotective peptide Urocortin I
Osteoarthritis (OA), a chronic degenerative condition of the diarthrodial joints is most predominant amongst the middle aged and elderly population, where it is associated with progressive disability and deformity of the joints. Whilst the exact mechanism of OA pathogenesis is currently unknown, …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
The aim of this study was to investigate the chondroprotective effect of tart cherry polyphenols (TCP) using human chondrocytes. Chondrocytes (SW 1353) were pre-treated with TCP at concentrations of 1.25, 2.5, 5, and 10 µg/mL for 24 h then stimulated with the recombinant interleukin-1β (20 ng/mL) …
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Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
Objective: To investigate the dose-dependent effects of whole tart cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and …
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Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
Objective: To investigate the dose-dependent effects of whole tart cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and …
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Simulated impact trauma and osteoarthritis: the role of cell volume and mechanotransduction
… of single mechanical load and the effects of chondroprotective agents over short periods of time (2-30 min) post impact. Mechanical load (force 1.14 N) induced by a drop tower device caused cell death from as early as 2 min. Pre-incubation in hypertonic media protected chondrocytes from cell …
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Mechanical loading and cartilage physiology
… mechanical impact, and the effects of possible chondroprotective agents for OA preventative strategies in individuals exposed to high impact, repetitive loading. Single-impact mechanical trauma (force 1.14 N, pressure 6.47 KPa) was determined to induce biphasic decrease in cell volume to …
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ALLOGRAFT DERIVED BIOSCAFFOLDS FOR TISSUE ENGINEERING OF THE MENISCUS: AN IN VIVO OVINE STUDY AND THE EFFECT OF HYPOXIC CULTURE ON SEEDED MENISCUS CONSTRUCTS
… vivo ovine meniscectomy model to determine their chondroprotective ability. These scaffolds were also used in in vitro culture under hypoxic conditions for the differentiation of mesenchymal stem cells toward a fibrochondrocyte phenotype. This work showed that meniscus scaffolds and cell seeded …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
… have synergistic antioxidant, chemo-preventive, chondroprotective, and anticancer activity. However, their poor aqueous solubility limits their oral application. The purpose of this study is to design, characterized, and evaluate a soluble and stable TASD containing CUR and RES with a hydrophilic …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
… on the observed dysregulation of anabolic and chondroprotective processes. The second part of this thesis expands the ex vivo cartilage explant monoculture PTOA model to use human donor knee cartilage. Proteins released into the media were clustered by the kinetics of their release over three …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… of collagens and proteoglycans, suggesting a chondroprotective effect of these compounds. Cannabinoids mediate their effects via putative cannabinoid receptors and activation of these receptors has been shown to display antiinflammatory activities and inhibition of destructive factors in human …
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
… melanocortin peptides. The antiinflammatory and chondroprotective effect of melanocortin peptides were then tested on in situ bovine articular chondrocytes, injured by a single blunt impact delivered by a drop tower. The mechanical injury caused significant cell death and up-regulation of the …
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Design of Biomaterials toward Endogenous Skeletal Tissue Repair
… joint retention. To enhance the longevity and chondroprotective function of hyaluronic acid supplementation, I report a design of self-healing supramolecular biomaterial by incorporating dynamic physical crosslinking into hyaluronic acid. Consequently, the supramolecular biomaterial exhibits …
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Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
… Findings in this aim highlighted the early chondroprotective effects of local PHA-408 following mechanical joint injury. Modest improvements in pain-sensitivity related outcomes with repeated drug treatment were also observed. Nevertheless, local delivery of PHA-408 failed to modify …