Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Chondroitin Sulphate"”.
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Expression, Purification, And Characterization Of Elastin-Like Polypeptides Containing Chondroitin Sulphate Binding Domains
… by the Woodhouse laboratory, as well as chondroitin sulphate-specific binding sequences (CSBD1 and CSBD2) determined by the Panitch laboratory, a new elastin-like polypeptide-chondroitin sulphate binding domain (ELP-CSBD) block copolymer has been developed and characterized. The …
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Biochemical Characterization of Normal Navicular Bone Flexor Surface Cartilage
… DNA, total collagen, total glycosaminoglycans, chondroitin sulphate, and keratan sulphate contents were determined. The results from each site were compared and the differences were analyzed by paired t-test (P < 0.05). Significant differences were determined between the water content of the …
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The design, development and testing of a non-invasive continuous crystalliser system for the study of calcium oxalate crystallisation processes
… inhibitors individually (citrate, magnesium, chondroitin sulphate A) and in combination (citrate and magnesium). The inhibitor experiments were performed using two different approaches. In the first, the pooled urine was pre-treated with the inhibitor prior to being introduced into the …
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Biosynthesis and degradation of proteoglycans in cultured smooth muscle cells
… synthesize proteoglycans that are more highly sulphated than those produced in the absence of ascorbate. The glycosaminoglycan chains associated with the proteoglycans synthesized by rat smooth muscle cells were heparan sulphate, chondroitin sulphate and dermatan sulphate. There was no evidence …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… protein (HSP)25, or plasticity-related proteins, chondroitin sulphate proteoglycans (CSPGs) or Nogo-A.
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Mechanical loading and cartilage physiology
… and antiinflammatory actions of chondroitin sulphate, glucosamine sulphate, REV 5901 and Tamoxifen were associated with a reduction in pre-impact cell volume (average of 31.91±4.19 %) and increased pre-impact actin levels (average of 39.92±9.29 %). Anti-inflammatory agents, …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… and caffeine (~9 folds), Curcumin (~9 folds) chondroitin sulphate A (~11 folds) and cocrystals with the coformer 5–Nitroisophthalic acid (~12 folds). Regardless, of the co–processing techniques applied with paracetamol in the presence of other drugs and excipient, there was an improvement of …
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Developing an astrocyte-selective AAV-ADAMTS4 gene therapy to promote repair after spinal cord injury
… are key contributors to the deposition of chondroitin sulphate proteoglycans (CSPGs) after injury, which are potent inhibitors to axon regeneration and plasticity. A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4) is a human enzyme that catalyses the proteolysis of …
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Antibody engineering to evaluate binding, internalisation, and intracellular routing of tumour-targeting fusion proteins
… chain variable fragment (scFv) specific to chondroitin sulphate proteoglycan 4 (CSPG4), a tumour-associated antigen often overexpressed in TNBC. The scFv antibody derivative was genetically fused to a SNAP-tag, enabling stable and site-specific conjugation of the scFv to diagnostic and …
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Synthesis and characterization of thermosensitive hydrogels derived from polysaccharides
… (here: the polysaccharides hyaluronic acid, chondroitin sulphate, or pectin, as well as the protein gelatin) were employed as additional macromolecular crosslinker to simultaneously incorporate an enzyme responsiveness into the systems. In order to have strong ionic/electrostatic interactions …
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Studies of plasticity after neuronal injury
… to promote plastic changes, that is, the enzyme chondroitinase ABC (ChABC) which degrades chondroitin sulphate proteoglycans - a major class of inhibitory extracellular matrix molecules. Viral vector technology was used to optimise the delivery of ChABC by gene transfer to host spinal cord cells. …
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Complex glycan utilization preferences of human gut bacteria
… bacteria: amylopectin (AP), arabinan (ARAB), chondroitin sulphate (CS), pectic galactan (PG), polygalacturonic acid (PGA), and rhamnogalacturonan I (RGI), and measured remaining substrates over time as well as PULs expression. Bt and Bo utilized some glycans before others, but with different …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
Over recent years the bacterial enzyme chondroitinase ABC (ChABC) has emerged as a promising experimental therapeutic for the treatment of spinal cord injury (SCI). In pre-clinical studies ChABC has repeatedly been shown to enhance functional recovery in a number of SCI models in both rodents and …
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Scientific aspects of urolithiasis : quantitative stone analyses and crystallization experiments
… acid, urea, creatinine, MgO, methylene blue, chondroitin sulphate A, fluoride) in the reference solution. Crystals formed in these experiments were subjected to qualitative and semi-quantitative X-ray powder diffraction analyses. Scanning electron microscopy of several deposits was also …
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Large Artery Stiffness: Genes and Pathways
… glycosylation of aggrecan, reflecting loss of chondroitin-sulphate binding domains. These differences were age-dependent but the striking finding was the acceleration of this process in stiff versus elastic young aortas. These findings suggest that aggrecan and fibulin-1 have critical roles in …
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Investigation of the potential beneficial effects of supplemental polyunsaturated fatty acids and glycosaminoglycans on the risk factors for calcium oxalate kidney stone formation using theoretical, experimental and human models
… acid (FA) supplementation (n-6 and n-3) and chondroitin sulphate (CS) supplementation may reduce the plasma (FA) and urinary (FA and CS) risk factors for CaOx renal stone formation, and ultimately serve as therapeutic agents in the management of this disease. The notion that FAs may reduce …
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Characterisation of novel matrix-binding interactions for latent transforming growth factor-β-binding protein-2 (LTBP-2), with emphasis on heparin and heparan sulphate proteoglycans.
… fibulin-5 and as yet unidentified heparan sulphate proteoglycans (HSPGs), have also been identified as playing important roles in this process. Fibrillins-1, -2, -3 and latent transforming growth factor-β binding protein (LTBP)-1, -2, -3, -4, associated components of fibrillin-microfibrils, …
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Studies of the interaction of hepatitis B virus with human haemopoietic cells.
… by up to 80%, and to leucocyte PM by up to 40%; chondroitin sulphare C (CS-C) enhanced virus binding (approximately 1.5-fold) to leucocyte pM only. Chondroitin sulphate A and hyaluronate had no effect on binding to either PM, arguing that simple electrostatic properties of GAGs were not …