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Showing 1 to 20 of 151 for “"Chondrocytes"”.
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Dynamic Properties of Chondrocytes
… movement and absorbs mechanical impact. Chondrocytes, the cells within cartilage, experience continuous mechanical loading in vivo and adapt their volume and shape accordingly, a process that is essential for maintaining cartilage health and function. Volume and shape changes in …
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The Aggregation of Chick Embryo Chondrocytes and The Characterization of an Aggregation Factor Produced by Chondrocytes in Culture
Made available in DSpace on 2014-12-14T04:27:37Z (GMT). No. of bitstreams: 1 7714951.pdf: 4293123 bytes, checksum: ea0e8045ef8b26eb8586f38ab43e9d3c (MD5) Previous issue date: 1977
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… identified Hh target genes that are expressed in chondrocytes. Microarray analyses were performed to detect changes in gene expression when the Hh pathway was modulated in human OA cartilage samples. Results from the Affymetrix Human Gene 1.0 ST microarray were analyzed for differentially …
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… on P2Y receptor activity in live articular chondrocytes by monitoring changes in the concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of calcium in the majority of cells tested (71 of 83 cells and 82 of 147 cells, respectively). In contrast, UDP …
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Studies on the Asparagine-Linked Oligosaccharides From Cartilage-Specific Proteoglycan (Chondrocytes)
Chondrocytes synthesize and secrete a cartilage-specific proteoglycan (PG-H) as one of their major products. This proteoglycan has attached to it several types of carbohydrate chains, including chondroitin sulfate, keratan sulfate, O-linked oligosaccharides, and asparagine-linked oligosaccharides. …
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
… primary bovine and in situ bovine articular chondrocytes. Pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α, produced by activated articular chondrocytes significantly up-regulate matrix metalloproteinases (MMPs) gene expression, and inhibit the chondrocyte’s compensatory …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… inhibition of destructive factors in human OA chondrocytes and synovial fibroblasts. This thesis demonstrates that the synthetic cannabinoid WIN-55 inhibits the expression of ECM degrading enzymes MMP-3 and MMP-13 both at the mRNA and protein level in human OA chondrocytes. WIN-55 also …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
… of tart cherry polyphenols (TCP) using human chondrocytes. Chondrocytes (SW 1353) were pre-treated with TCP at concentrations of 1.25, 2.5, 5, and 10 µg/mL for 24 h then stimulated with the recombinant interleukin-1β (20 ng/mL) for 24 hours. After an initial increase (p<0.05) in cell …
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Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
The mechanical properties of articular cartilage are associated with the extracellular matrix network of type II collagen and the proteoglycan, aggrecan, which in combination provide the tensile, shear, and compressive stiffness of the tissue. While the collagen network mainly provides resistance …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… increases intracellular levels of ROS in chondrocytes, while antioxidants block FN-f stimulated MMP-13 expression, demonstrating ROS are critical regulators of this pathway. However, the means by which ROS regulate this pathway are unknown. Therefore, the objective of this work was to …
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Radiologic, Histologic and Functional Analysis after Transplantation of Autologous Cultured Chondrocytes into Trachea and Vocal Fold
… acid (HA) composite gel with autologous chondrocytes for tracheal reconstruction. Chondrocytes from autologous rabbit auricular cartilages were expanded and seeded into a culture dish at high density to form stable tracheal cartilages mechanically using a fibrin/HA composite gel. A 1-cm …
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Investigation of Cellular Responses Activated by Mechanical Compression in Equine Chondrocytes: Device Design, Construction and Testing
The metabolic activity of cartilage cells (chondrocytes) is regulated by mechanical forces which act on them. Chondrocytes can respond to these forces through synthesis or degradation of extracellular matrix and changes in gene expression. The overall objective of this study was to investigate the …
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Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for reasons unrelated to joint disease. Chondrocyte pellets were treated with media (negative control); media containing IL-1 only (positive control); or media containing IL-1 …
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