Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cholinesterase Inhibitors"”.
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Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
In vitro testing of cholinesterase inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… memory loss and behavioural abnormalities. Cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate receptor (NMDAR) antagonists are current treatment options for mild to moderate AD. These agents are not used to cure the illness, but rather as symptomatic therapy. Heat Shock Protein …
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… AD. This has been a target for therapy since the cholinesterase inhibitors (ChEIs) (tacrine, donepezil, rivastigmine, galantamine) were introduced as treatments for AD. Multiple short-term randomised clinical trials of ChEI treatment show beneficial effects on cognition, global functioning and …
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Antioxidant and anticholinesterase activities of centella asiatica phenolic extract-mediated gold nanoparticles
… contents (TPC and TFC), antioxidant and anticholinesterase (anti-ChE) activities were also tested in vitro and Pearson correlation analysis was performed. The GNP synthesis using CAP was successfully accomplished under optimum conditions of reactants ratio of 1:1, 8 % CAP concentration, 0.5 …
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Changes in cerebral glucose metabolism in patients with Parkinson’s disease with dementia after cholinesterase inhibitor therapy
… disease dementia (PDD) patients after cholinesterase inhibitor therapy. BACKGROUND: Cholinesterase inhibitors (ChEI) are now widely used with proven efficacy in patients with PDD. There have been several reports describing how the drugs are benefiting the PDD patients in terms of …
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Changes in Brain Functional Connectivity Following Donepezil Treatment in Alzheimer's Disease
… disease (AD) following treatment with the cholinesterase inhibitor, donepezil. The ROIs were selected on the basis of their association with cholinergic neurotransmission, AD neuropathology, and neurocognitive deficits in AD. These ROIs included the medial septal nuclei, left and right …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… in responses seen after exposure to stress and cholinesterase inhibitors. Effects of concurrent exposure to repeated stress and chlorpyrifos (CPF) on concentrations of excitatory amino acids, activities of cholinergic enzymes, and maximum binding density (Bmax) and equilibrium dissociation rate …
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CUMULATIVE ANTICHOLINERGIC BURDEN AND ASSOCIATED OUTCOMES AMONG OLDER ADULTS WITH ALZHEIMER’S DISEASE
… adults with Alzheimer’s disease (AD) initiating Cholinesterase inhibitors (ChEIs); (2) Assess the risk of delirium associated with cumulative anticholinergic burden in older adults with AD; (3) Evaluate the treatment modification among older adults with AD after a delirium event. Methods: This …
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Long Term Outcome and Prediction Models of Cognition, Activities of Daily Living and Nursing Home Placement in Alzheimer’s Disease with Cholinesterase Inhibitor Treatment
… studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. Knowledge about the predicted course of the disease, …