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Showing 1 to 15 of 15 for “"Cholic Acid"”.
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The enclathration of alcohols by cholic acid
A series of crystalline Cholic acid inclusion compounds were studied with a view to understanding the role of guest molecules in inducing and stabilizing a particular Cholic acid (host) lattice structure. Alcohols in the series CH₃(CH₂nOH (n= 0 to 3 and 2-propanol) were employed as guest molecules …
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Dietary cholesterol, tissue phospholipids and prostacylin production of rat aorta
… and the control diet plus both cholesterol and cholic acid. After four months the animals were sacrificed and blood samples, along with abdominal and thoracic aorta cross-sectional ring segments. were collected. The serum cholesterol levels, fatty acid compositions in the phospholipids (PL) of …
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The Effect of Hypercholesterolemia on the Membrane Lipids, 3-0-[¹⁴C] Methylglucose Transport, and 2,3-Diphosphoglycerate Levels in Rat Erythrocytes
<p>An increase in dietary cholesterol and cholic acid will produce hypercholesterolemia in rats. For ten months, two groups of rats (six in each group) were fed commercial rat pellets (control group) or rat pellets plus cholesterol (1%) and cholic acid (0.25%) (experimental group). A blood sample …
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Role of TGR5 in Bile Acid Metabolism
TGR5 is a G protein-coupled bile acid receptor present in various tissues in the body. Its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its …
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Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… cells. We subsequently identified Cholic Acid (CA), a microbial bile acid that was increased in both patients and murine models with exercise, as a likely mediator of exercise induced reduction in iCAFs. Consistent with these findings, patients that exercised more also exhibited …
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The gallbladder epithelium in experimental cholelithiasis
… diet containing 1% cholesterol and 0.5% cholic acid for 42 days, and (c) guinea pigs when given subcutaneous injections of Lincomycin (60 mg/kg) for 7 days. 2. The morphological changes in the gallbladder epithelium during gallstone formation have been studied with light microscopy and …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… ADAM11. Utilizing low and high cholesterol and cholic acid containing diets and the ADAM11 knockout, we did not find a phenotype for ADAM11 with respect to plasma cholesterol or triglyceride levels, liver lipid levels, gallbladder bile composition, glucose tolerance, or atherosclerosis …
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TOWARDS UNDERSTANDING MODE-OF-ACTION OF TRADITIONAL MEDICINES BY USING IN SILICO TARGET PREDICTION
… synergistic combinations, ginsenoside Rb3 and cholic acid, ginsenoside Rb2 and ginsenoside Rb3, ginsenoside Rb3 and 11-hydroxyprogesterone and ginsenoside Rb2 and ginsenoside Rd agreed with the experimental results. The modulation of androgen receptor, epidermal growth factor and caspases were …
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In-Vivo and In-Vitro Cholesterol Removal by Lactobacilli and Bifidobacteria
Four strains of Lactobacillus acidophilus, eleven strains of L. casei and five strains of Bifidobacterium were studied for their acid and bile tolerance. Possible mechanisms of cholesterol removal were also examined. All strains showed varying levels of tolerance at pH 2.0 for two hours. L. …
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… levels of cholesterol in gallbladders and of cholic acid in serum indicated a shifted metabolite profile in bile acid metabolism and disruption of enterohepatic circulation in the Abcc6-/- mouse model.<br /> Remodeling of the ECM in PXE fibroblasts in two- and three-dimensional culture proved …
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The role of the gut microbiota in the function and integrity of brain barriers
… concentrations of short chain fatty acids (SCFAs), butyrate and propionate, with and without induced barrier dysfunction (LPS) on the actin cytoskeleton and tight junction protein dynamics using an in vitro BBB model. We found that the butyrate and propionate altered filamentous actin …
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Molecular selectivity by host-guest methods
… of the trimethoxybenzene (TMB) isomers, cholic acid and deoxycholic acid' hosts were used in chapter 3. It was found that each host separated the isomers differently. That was independent of the closeness of their molecular structures. The difference in selectivity was attributed to the …
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Role of Src phosphorylation of FXR in bile acid regulation
Bile acids are physiological detergents which aid in the absorption of dietary lipids and lipid soluble vitamins but also function as fed state signaling molecules. Elevated bile acid levels in the liver can lead to cholestatic injury, primary biliary cirrhosis, fibrosis, and liver cancer; …
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Valorisation of waste streams within the agri-food sector
Over the twenty-year period between 1998 and 2018 the number of full-time farmers within the Northern Ireland (NI) agri-tech sector dropped from 22,524 to 16,964. As expected, this has also resulted in a commensurate loss in the total cattle livestock which has decreased from 1.77 million to 1.63 …