Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cholesterol lowering drugs"”.
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Development of genotyping systems for pharmacogenomics profiling
… ten polymorphisms related to anticancer drugs and ten polymorphisms related to cholesterol lowering drugs. SNaPshot minisequencing and high resolution melt analysis (HRM) genotyping panels were developed, optimized, and their performances were evaluated and compared. SNaPshot …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… growth inhibition. Depletion of lipid rafts via cholesterol reduction results in sensitivity of EGFR TKI resistant breast cancer cell lines to the EGFR TKI gefitinib. Importantly, the effects of cholesterol lowering drugs and EGFR TKI in combination were synergistic. We have shown that the …
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Medical data mining : improving information accessibility using online patient drug reviews
… significant association between a class of cholesterol-lowering drugs called statins, and a wide range of alarming disorders, including depression, memory loss, and heart failure. We also develop an initial language model for speech recognition in the medical domain, with transcribed data on …
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… treatments. Research has shown diets high in cholesterol increase the incidence of aggressive breast cancers and pre-clinical research has shown cholesterol can fuel the growth of breast cancer in vivo. Studies at MD Anderson have shown that IBC patients taking cholesterol lowering drugs, …
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Studies on cholesterol metabolism in prostate cancer cells
… studies have associated high blood-cholesterol levels with an increased risk of PCa, whilst cholesterol-lowering drugs (statins) reduce the risk of advanced PCa. Furthermore, PCa cells have been found to accumulate large amounts of cholesterol. Why and how does this happen? This …
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The impact of cholesterol and its metabolites on the ovarian tumor microenvironment and cancer progression
… In this regard, we and others have found that cholesterol appears to be clinically important for ovarian cancer survival, highlighting it and its metabolism as potential therapeutic targets for improving the lifespan of patients. In a cohort of 153 patients, we found high total, LDL or non-HDL …
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… one cause of mortality world wide. High blood cholesterol is linked to CVD and is an important risk factor. Statins – cholesterol lowering drugs- are first choice drugs for reducing the chance of suffering a CVD event. In the USA alone, approximately 32 million individuals take statins. …