Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Cholesterol biosynthesis pathway"”.
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A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
Cholesterol has been shown to play important role in the pathogenesis and persistence of intracellular pathogens. Here, we modulate host cholesterol biosynthesis pathway using pharmacological agent statins, which are reversible inhibitors of HMG†CoA reductase enzyme. The aim of the study was to …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… ester transfer protein (CETP), which transports cholesterol esters and triglycerides between different lipoprotein particles. Loss-of-function mutations in CETP are associated with better cognition in aging. To investigate the role of CETP in AD, human CETP transgenic mice were crossed with an …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
… (HMGCR) catalyses the rate-limiting step in the cholesterol biosynthesis pathway and is targeted therapeutically by statins. To maintain cholesterol homeostasis, the expression of HMGCR is tightly regulated by sterols transcriptionally and post-translationally. Sterols induce the association of …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… fatty acid oxidation, primarily through PPARα pathway. </p> <p> Farnesyl pyrophosphate (FPP) is a branch-point intermediate in the mevalonate pathway that is normally converted mainly to squalene by squalene synthase in the first committed step of sterol biosynthesis. Treatment with the …