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Showing 1 to 20 of 38 for “"Cholesterol biosynthesis"”.
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Regulation of Cholesterol Biosynthesis in Hepatocytes
Hypercholesterolemia, a condition of high cholesterol levels in the circulation, poses a major risk for developing cardiovascular disease, such as atherosclerosis. A common method of reducing plasma cholesterol levels relies on the administration of drugs that limit cholesterol synthesis or uptake, …
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Fatty Acid and Cholesterol Biosynthesis, Plasma and Tissue Lipid Levels in Swine
Made available in DSpace on 2015-05-13T15:26:53Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7524323.PDF: 4934364 bytes, checksum: ecdc37d8608a0244faad4082b2718a1e (MD5) Previous issue date: 1975
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
<p>Cells obtain cholesterol in two ways, <em>de novo</em> biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
<p>Cells obtain cholesterol in two ways, <em>de novo</em> biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion …
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Studies of the Metabolism of Vitamin a - 9,10-Carbon-14 Acetate and the Effect of Vitamin a Deficiency on Cholesterol Biosynthesis
Made available in DSpace on 2014-12-05T17:47:46Z (GMT). No. of bitstreams: 1 6100220.pdf: 2705483 bytes, checksum: 60bed4f22c3d4dc488ecfb18d4bc7101 (MD5) Previous issue date: 1960
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Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
Proper cholesterol homeostasis is crucial in mammalian development. Currently, there are 8 known human malformation syndromes due to genetic defects in cholesterol biosynthesis. Patients with these syndromes present with a constellation of developmental defects, ranging from skeletal and …
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
… are indispensable for feedback inhibition of cholesterol biosynthesis. Mice null for both Insigs drastically overproduce cholesterol and its precursor sterol intermediates and exhibit many developmental abnormalities such as cleft palate. In this work, we generate and characterize a line of …
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The effects of dietary protein source on the development of cholesterol metabolism
… of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult …
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A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
Cholesterol has been shown to play important role in the pathogenesis and persistence of intracellular pathogens. Here, we modulate host cholesterol biosynthesis pathway using pharmacological agent statins, which are reversible inhibitors of HMG†CoA reductase enzyme. The aim of the study was to …
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Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… neuro-inflammation and dysregulation of cholesterol homeostasis, all of which play a role in neuro-degeneration. The main aim of this study was to determine possible relationships between insulin signaling, cholesterol biosynthesis and their effects on Aβ, and inflammatory response in …
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An omics study into the molecular impact of autosomal dominant APP and MAPT mutations on the cerebral cortex
… each iPSC line, I identify an upregulation of cholesterol biosynthesis genes in excitatory and inhibitory neurons and astrocytes carrying MAPT E10+16 mutation compared to the isogenic control cells. I corroborate cholesterol synthesis upregulation in VGLUT1+ excitatory neurons carrying MAPT …
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Impacts of Oil Exposure During Early Life Development Stages In Sheepshead Minnows (<i>Cyprinodon variegatus</i>) Under Different Environmental Factors
… in all treatment comparisons included cholesterol biosynthesis, cardiotoxicity, and hepatoxicity. These findings indicate that the post-larval stage is the most sensitive to oil and environmental stress.</p>
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Proteomic insights into the modulation of foetal neurogenesis by the anti-retroviral efavirenz
… enriched deregulated pathways included cholesterol biosynthesis, mRNA splicing, and JAK/STAT and Wnt signalling. Conclusions: Efavirenz-altered protein expression reflects functional pathway perturbations, which may contribute to clinically-observed neurological effects. Orthoganal and …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… We hypothesized that Hh signaling regulates cholesterol biosynthesis in chondrocytes, and that modulating cholesterol homeostasis impacts the severity of OA. To investigate the function of cholesterol in the cartilage, mice with chondrocyte-specific cholesterol accumulation were generated. …
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Structure and Function of the ER-Membrane Complex
… inter-organelle phospholipid transfer, cholesterol biosynthesis and the biogenesis of multi-pass membrane proteins. Although the complex was formally identified nearly 10 years ago, direct biochemical evidence for functional roles is sparse. Only in the last two years have mechanistic …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… Reductase (HMGCR), the rate limiting enzyme in cholesterol biosynthesis. Under sterol rich conditions, HMGCR is rapidly degraded through ERAD, however, when sterols are limited, HMGCR is stabilised through decreased degradation and increased transcription by the transcription factor SREBP2. As …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… the physiological and/or pathological role of cholesterol on beta- and alpha-cells is less well examined. Cholesterol is the major component of membrane microdomains, termed lipid rafts. Numerous signaling and transport proteins have been found to be targeted to lipid raft microdomains, where …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
… The first three chapters explore the role of cholesterol in synaptic transmission. We treated hippocampal cultures with methyl-beta-cyclodextrin, which reversibly binds cholesterol, or mevastatin, an inhibitor of cholesterol biosynthesis, to deplete cholesterol. We also used hippocampal …
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… in Pit1dw/dwJ mice comprised of genes regulating cholesterol biosynthesis, fatty acid utilization, and lipoprotein metabolism. Affecting global energy homeostasis, this programmatic shift in hepatic expression may contribute to longevity by influencing bioenergetic and oxidative reactions …
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