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Showing 1 to 11 of 11 for “"Cholesterol binding"”.
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Cholesterol Binding Activity of ApoAI Mimetic Peptide L4F
… accumulation of lipids- more specifically cholesterol. Thus, managing the levels of cholesterol can prove to be a very effective strategy in preventing or treating several cardiovascular disorders. ApoA-I mimetic peptides are promising candidates in this respect. L4F is a synthetic apoA-I …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes, allowing cholesterol to be released. Export of cholesterol from late endosomes and lysosomes (hereafter referred to as lysosomes) …
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Variability of Cholesterol Accessibility in Human Red Blood Cells Measured Using a Bacterial Cholesterol Binding Toxin
Cholesterol partitions into accessible and sequestered pools in cell membranes. Here, we describe a new assay using fluorescently-tagged anthrolysin O, a cholesterol-binding bacterial toxin, to measure accessible cholesterol in human red blood cells (RBCs). Accessible cholesterol levels were stable …
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The Hydrophobic Handoff Between NPC2 and the N-Terminal Domain of NPC1 in the Export of Cholesterol from Lysosomes
… (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes where its cholesterol is released. Egress of cholesterol from late endosomes and lysosomes (hereafter referred to as lysosomes) …
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Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole
… There is growing evidence that host cell cholesterol trafficking plays a critical role in PV development and maintenance, prompting an examination of the role of cholesterol-binding host protein ORP1L (Oxysterol binding protein-Related Protein 1, Long) during infection. ORP1L is a …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
Cholesterol synthesis in mammalian cells is highly regulated by an end-product feedback mechanism. The transcription of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the …
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Biochemical Characterization of Niemann-Pick C: A Disease of Cholesterol Transport
… scientific interest, the mechanism by which cholesterol is transported between membrane compartments in animal cells remains obscure. One transport pathway begins in lysosomes where cholesterol is liberated from plasma lipoproteins that have entered the cell through receptor-mediated …
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Cholesterol Modulation of BK Currents and Cerebral Artery Diameter Via Channel-Forming Alpha-Subunit
… mediate numerous physiological processes. Cholesterol is consumed in high amounts with the diet and accumulates in cellular membranes when plasma levels become elevated. Cholesterol is a known inhibitor of BK channels and is suspected of contribution to many pathophysiological issues via …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… mechanosensitivity is repressed by podocin, a cholesterol-binding, membrane-associated partner of the TRPC6 channel. In addition, podocin mediates diacylglycerol activation of TRPC6, suggesting that podocin determines the favored mode of TRPC6 activation in podocytes. It is possible that …
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Studies on the optimization of expression and purification & Functional characterization of Class C – GPCRs
… by diverse activating endogenous ligands binding on the extracellular surface. This results in the uncoupling of G-proteins from the cytoplasmic loops, leading to the activation of the second messengers. GPCRs have enormous therapeutic importance due to their involvement in basic …
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Characterization Of Streptolysin O As The Translocator For The Cytolysin-Mediated Translocation Process In Streptococcus Pyogenes
… Moreover, CMT is unaffected by extraction of cholesterol to levels that block membrane binding by the cholesterol-dependent PFO protein. Although cholesterol is unnecessary, mutations that interrupt cholesterol binding by SLO indicate the sterol does increase the efficiency of CMT. …