Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Cholesterol Trafficking"”.
-
Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
High blood cholesterol (HBC) is an important risk factor of cardiovascular disease (CVD), which is associated with high morbidity and mortality worldwide. Lifestyle changes and drugs (e.g. statins) are mainly advised by practitioners to manage cholesterol; however, safer alternatives such as …
-
Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… drugs indicated that they affect intracellular cholesterol trafficking and the intermediates of the cholesterol synthesis pathway. Furthermore, simvastatin prevented cell migration and seemed to cause cell death through apoptosis. Our in vitro and in vivo studies indicate the potential of these …
-
Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole
… There is growing evidence that host cell cholesterol trafficking plays a critical role in PV development and maintenance, prompting an examination of the role of cholesterol-binding host protein ORP1L (Oxysterol binding protein-Related Protein 1, Long) during infection. ORP1L is a …
-
Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
… The first three chapters explore the role of cholesterol in synaptic transmission. We treated hippocampal cultures with methyl-beta-cyclodextrin, which reversibly binds cholesterol, or mevastatin, an inhibitor of cholesterol biosynthesis, to deplete cholesterol. We also used hippocampal …
-
Evaluating the Mechanisms of 2-Hydroxypropyl-β-Cyclodextrin and Liver X Receptor Agonists as Potential Therapies for Niemann-Pick Type C Disease
Cholesterol is essential to life; therefore, the synthesis, entry, and efflux of cholesterol are tightly regulated. In some rare disease states, such as in Niemann-Pick Type C, cholesterol balance is lost leading to detrimental effects. In Niemann-Pick Type C, mutations in either of the cholesterol …
-
Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells
… by lipids and advanced the ability to image cholesterol in cells and tissues. The unbiased proteomic analysis of fatty-acylated proteins using chemical reporters undertaken here revealed a greater diversity of lipid-modified proteins in mammalian cells than had previously been appreciated. …
-
The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… elucidate this mechanism, two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol (25-OHC), were used to induce apoptosis in murine macrophage cell lines (P388D1, and Raw 264.7) and mouse peritoneal macrophages (MPMs). Pharmacological inhibition of eicosanoid synthesis or genetic knockout of …
-
Characterization of a Novel NPC1I1061T Knock-in Mouse Model of Niemann-Pick Type C1 Disease
… Type C (NPC) disease is a fatal pediatric cholesterol storage disease that is caused by mutations in either the <italic>npc1</italic> or <italic>npc2</italic> genes. Loss of function of either gene results in toxic storage of free cholesterol in the lysosomes due to a cholesterol …
-
Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… like inflammatory bowel disease (IBD) and hypercholesterolemia. We first assessed LOBs and ENL effects on barrier integrity (a pathological hallmark of IBD) in vitro using a monoculture transwell system, and the potential mechanisms involved in maintenance of the barrier. Next, we examined their …
-
Characterising the role of GPR50 in neurodevelopment and lipid metabolism
… cells, this was mimicked by the inhibition of cholesterol trafficking, suggesting the translocation of GPR50 to the plasma membrane is dependent on cholesterol transport. Further, the depletion of lipoproteins resulted in the downregulation of GPR50, indicating a responsiveness to lipid levels. …