Global ETD Search
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Showing 1 to 4 of 4 for “"Cholestatic liver disease"”.
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
Liver fibrosis is the result of different types of chronic liver diseases, such as cholestatic liver disease and nonalcoholic steatohepatitis, among others. Fibrosis, if left unchecked, may progress to the point of cirrhosis – permanently affecting liver function detrimentally and potentially …
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Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
… cholangitis (PSC) is a progressive chronic cholestatic liver disease, affecting young males predominantly. It causes stricturing of the intrahepatic and extrahepatic bile ducts, often leading to biliary cirrhosis, with an increased risk of colorectal and hepato-biliary malignancy. It is …
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Machine learning and data analytics for liver disease modeling
… cholangitis (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical …
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Primary biliary cholangitis: genetic risk, phenotypic stratification and disease pathogenesis
Primary biliary cholangitis (PBC) is a rare disease which occurs in fewer than 1 in 2,000 people, mainly women over the age of 40. It is an autoimmune condition and is phenotypically associated with other immune-mediated inflammatory disorders (IMIDs). It is characterised by progressive destruction …