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Showing 1 to 20 of 25 for “"Cholestasis"”.
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On Leukocyte Recruitment in Cholestatic Liver Injury
Cholestasis is a frequent clinical syndrome, which is caused by a dysfunction in bile formation of the hepatocyte or from obstruction of the biliary tract. This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment …
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Auswirkungen der obstruktiven Cholestase auf die intestinale Expression von MRP2 bei Ratten und Menschen
… regulated in liver and kidney during cholestasis, but little is known about its regulation in the intestine. We investigated duodenal protein expression of MRP2 in male Sprague-Dawley rats with bile duct ligation (BDL) or biliary diversion as well as in 20 cholestatic patients with …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
Estrogen-mediated cholestasis is an important clinical entity, but its molecular pathophysiology is still not fully understood. The phenomenon of intrahepatic cholestasis under estrogen influence can occur during pregnancy or by taking estrogens for oral anticonception and hormone substitution. …
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The differentiation of extrahepatic biliary atresia from the neonatal hepatitis syndrome
The differentiation, in an infant with cholestasis, between extrahepatic biliary atresia (EHBA) and the neonatal hepatitis syndrome (NHS) is important in that laparotomy is always indicated in EHBA but is undesirable in NHS. This differentiation is particularly difficult in those infants with …
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Genetische Prädisposition der intrahepatischen Schwangerschaftscholestase : Mutationsanalyse des Phospholipidtransporters ABCB4 und der Gallensäurenexportpumpe ABCB11
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder with a complex aetiology: Hormonal factors, exogenous influence and, in patients with high gamma-glutamyl transferase (GGT), heterozygous mutations in the ABCB4 gene encoding the hepatic canalicular phospholipid transport protein MDR3 …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… was continuously increasing with duration of cholestasis. Smad2 and 4 expression levels were unchanged. Smad3 expression was decreased, while hepatocytes of fibrotic lesions exhibited Smad3. Conclusions: Hepatocytes of damaged liver tissue display increased TGF-beta signaling via Smad3. …
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Characterisation of the role of VPS33B in Vesicular trafficking in polarised Epithelial cells.
Arthrogryposis, Renal dysfunction, and Cholestasis (ARC) syndrome is a multisystem disorder associated with abnormal localisation of some polarised membrane transporter proteins. Distinct apical and basolateral poles are essential for epithelial function and organ development but the molecular …
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Structure of the Human VPS33B/VPS16B Complex
… can cause arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome, a rare neonatal lethal condition with symptoms affecting many organ systems. These proteins form a VPS33B/VPS16B complex which is required for many cellular processes, including the production by bone marrow …
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Effect of experimental complex III deficiency on respiratory chain assembly and function
… syndrome (growth restriction, aminoaciduria, cholestasis, iron accumulation, lactic acidosis, and early death, MIM 603358). To clarify the mechanisms of BCS1L-related disorders, especially possible changes in supercomplex formation, the specific aims of this thesis were to investigate CIII …
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Taurocholat-Transport in isolierten proximalen Tubuluszellen der Ratte : Einfluss einer extrahepatischen Cholestase
… acids is negligible low. During extrahepatic cholestasis, when bile acid concentrations in the plasma are enhanced, there is, according to our studies, an adaptive renal mechanism facilitating urinary excretion of bile acids. The aim of the study was to elucidate whether this adaptive …
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Primary sclerosing cholangitis
… outcome. Presentation was usually with insidious cholestasis or recurrent cholangitis. Twenty six patients (72 per cent) had associated inflammatory bowel disease (ulcerative colitis 20, Crohn's disease 2, unclassified 4). Thirty two patients were followed prospectively for up to nine years. …
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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid
… bile canaliculi, and form bile plugs leading to cholestasis fol owed by liver injury. Both ferrochelatase (<em>FECH</em>/<em>Fech</em>) and aminolevulinic acid synthase 1 (<em>ALAS1</em>/<em>Alas1</em>) are crucial enzymes in regulating heme biosynthesis. Isoniazid has recently been reported to …
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… target for the prevention and/or treatment of cholestasis, hyperlipidemic disorders, metabolic syndrome, and liver and colon cancer. Studies suggest epigenetic mechanisms are critical for proper transcriptional induction of nuclear receptors. Likewise, evidence shows epigenetic mechanisms are …
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The Immunogenicity of Cholangiocyte Cellular Therapies
… of life-threatening conditions characterised by cholestasis, ductopenia and eventual liver failure. There are currently no curative treatments for cholangiopathies aside from liver transplantation and while individual cholangiopathies are rare, together they account for a third of adult and 70% …
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Human Liver Organoids as models for investigating drug-induced liver injury
… of transmembrane proteins in a process called cholestasis. Furthermore, formation of typical features of drug-induced steatosis were observed upon treatment with steatotic drugs. In summary, our findings highlight how this novel differentiated organoid system could be a relevant human in vitro …
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
… defects in hepatic bile acid export, termed cholestasis, results in bile acid accumulation in hepatocytes and is a well-described form of liver injury and disease. In contrast to liver, it was unknown whether bile acid accumulation in intestinal enterocytes can also lead to disease. Blocking …
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The function of TAK1 in hepatocarcinogenesis
… of HCC coinciding with biliary ductopenia and cholestasis.
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Regulation des renalen Natrium-abhängigen Gallensäuren-Transporters (ASBT) durch Sexualhormone und Glukokortikoide
… change was due to an ethinylestradiol induced cholestasis. The main finding of this study was a significant higher tubular taurocholate clearance and therefore less intracellular taurocholate accumulation in female compared to male rats. This gender-specific difference is likely to be due to an …
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Placental growth factor; potential for its use in twin pregnancy and evaluation of its benefit in singletons with suspected preterm pre-eclampsia
… use of a donor oocyte, and presence of obstetric cholestasis are all important risk factors for the development of a hypertensive disorder in a twin pregnancy. The incidence of iatrogenic late prematurity and neonatal hypoglycaemia are increased when a hypertensive disorder complicates a twin …
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Role of Src phosphorylation of FXR in bile acid regulation
… when challenged in models simulating cholestasis, these signs of liver damage are dramatically elevated in mice expressing Y67F-FXR. These in vivo studies demonstrate that disruption of the FXR tyrosine-67 site drastically impairs FXR’s ability to regulate its target genes, maintain …
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