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Showing 1 to 18 of 18 for “"Cholestasis"”.
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On Leukocyte Recruitment in Cholestatic Liver Injury
Cholestasis is a frequent clinical syndrome, which is caused by a dysfunction in bile formation of the hepatocyte or from obstruction of the biliary tract. This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment …
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The differentiation of extrahepatic biliary atresia from the neonatal hepatitis syndrome
The differentiation, in an infant with cholestasis, between extrahepatic biliary atresia (EHBA) and the neonatal hepatitis syndrome (NHS) is important in that laparotomy is always indicated in EHBA but is undesirable in NHS. This differentiation is particularly difficult in those infants with …
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Characterisation of the role of VPS33B in Vesicular trafficking in polarised Epithelial cells.
Arthrogryposis, Renal dysfunction, and Cholestasis (ARC) syndrome is a multisystem disorder associated with abnormal localisation of some polarised membrane transporter proteins. Distinct apical and basolateral poles are essential for epithelial function and organ development but the molecular …
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Structure of the Human VPS33B/VPS16B Complex
… can cause arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome, a rare neonatal lethal condition with symptoms affecting many organ systems. These proteins form a VPS33B/VPS16B complex which is required for many cellular processes, including the production by bone marrow …
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Effect of experimental complex III deficiency on respiratory chain assembly and function
… syndrome (growth restriction, aminoaciduria, cholestasis, iron accumulation, lactic acidosis, and early death, MIM 603358). To clarify the mechanisms of BCS1L-related disorders, especially possible changes in supercomplex formation, the specific aims of this thesis were to investigate CIII …
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Primary sclerosing cholangitis
… outcome. Presentation was usually with insidious cholestasis or recurrent cholangitis. Twenty six patients (72 per cent) had associated inflammatory bowel disease (ulcerative colitis 20, Crohn's disease 2, unclassified 4). Thirty two patients were followed prospectively for up to nine years. …
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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid
… bile canaliculi, and form bile plugs leading to cholestasis fol owed by liver injury. Both ferrochelatase (<em>FECH</em>/<em>Fech</em>) and aminolevulinic acid synthase 1 (<em>ALAS1</em>/<em>Alas1</em>) are crucial enzymes in regulating heme biosynthesis. Isoniazid has recently been reported to …
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… target for the prevention and/or treatment of cholestasis, hyperlipidemic disorders, metabolic syndrome, and liver and colon cancer. Studies suggest epigenetic mechanisms are critical for proper transcriptional induction of nuclear receptors. Likewise, evidence shows epigenetic mechanisms are …
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The Immunogenicity of Cholangiocyte Cellular Therapies
… of life-threatening conditions characterised by cholestasis, ductopenia and eventual liver failure. There are currently no curative treatments for cholangiopathies aside from liver transplantation and while individual cholangiopathies are rare, together they account for a third of adult and 70% …
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Human Liver Organoids as models for investigating drug-induced liver injury
… of transmembrane proteins in a process called cholestasis. Furthermore, formation of typical features of drug-induced steatosis were observed upon treatment with steatotic drugs. In summary, our findings highlight how this novel differentiated organoid system could be a relevant human in vitro …
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
… defects in hepatic bile acid export, termed cholestasis, results in bile acid accumulation in hepatocytes and is a well-described form of liver injury and disease. In contrast to liver, it was unknown whether bile acid accumulation in intestinal enterocytes can also lead to disease. Blocking …
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Placental growth factor; potential for its use in twin pregnancy and evaluation of its benefit in singletons with suspected preterm pre-eclampsia
… use of a donor oocyte, and presence of obstetric cholestasis are all important risk factors for the development of a hypertensive disorder in a twin pregnancy. The incidence of iatrogenic late prematurity and neonatal hypoglycaemia are increased when a hypertensive disorder complicates a twin …
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Role of Src phosphorylation of FXR in bile acid regulation
… when challenged in models simulating cholestasis, these signs of liver damage are dramatically elevated in mice expressing Y67F-FXR. These in vivo studies demonstrate that disruption of the FXR tyrosine-67 site drastically impairs FXR’s ability to regulate its target genes, maintain …
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Primary biliary cholangitis: genetic risk, phenotypic stratification and disease pathogenesis
… small, intra-hepatic bile ducts, causing chronic cholestasis, progressive fibrosis and leading in many cases to cirrhosis and end stage liver disease. Treatment options are limited and the disease spectrum encompasses those patients with an adequate response to treatment and a transplant-free …
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Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
Liver performs a multitude of functions ranging from detoxification, metabolism and digestion. To execute these tasks, one of the mechanisms that the liver utilizes is nuclear receptor signaling, which in turn can transcriptionally regulate gene networks. My doctoral thesis focuses on studying the …
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Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Η μελέτη της επίδρασης του οξειδωτικού στρες στην οκλουδίνη, βασικού δομικού μορίου των στενών δεσμών (tight junctions) του αιματοεγκεφαλικού φραγμού σε επίμυες. Μελέτη της πιθανής προφυλακτικής επίδρασης αντιοξειδωτικών παραγόντων
Ο αιματο-εγκεφαλικός φραγμός (ΑΕΦ) παίζει έναν καθοριστικό ρόλο στην ομοιόσταση του Κεντρικού Νευρικού Συστήματος. Οι στενοσύνδεσμοι (TJ) των ενδοθηλιακών κυττάρων των εγκεφαλικών τριχοειδών συνεισφέρουν σημαντικά στη λειτουργία του ΑΕΦ περιορίζοντας την παρακυτταρική διάχυση. Η οκλουδίνη, μια …