Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Cholecystokinin"”.
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Brain distribution and release of Cholecystokinin octapeptide
In this thesis the in vitro release of immunoreactive CCK₈ (iCCK₈) from rat central nervous system preparations and the regulation of this release have been studied. Rat brain was dissected into the following regions; hypothalamus, cerebral cortex, striatum and thalamus, according to the method of …
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Development of new radiopharmaceuticals targeting the Cholecystokinin 2 receptor
Il percorso di studi sperimentali del presente Ph.D è stato incentrato sullo sviluppo di radiofarmaci innovativi e sulla loro valutazione preclinica. Il progetto è stato inquadrato all’interno della “filiera del radiofarmaco” nata a Catania grazie alla collaborazione instaurata tra il Center for …
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
… networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… to the discovery that the related protein, preprocholecystokinin, also promotes impressive beta cell growth, in addition to enhanced beta cell function, as measured by improved glucose-stimulated insulin secretion. Several additional experiments suggest that traditional plasma membrane receptors …
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The synthesis and evaluation of small organic molecules as cholecystokinin antagonists
Cholecystokinin (CCK) is a peptide hormone, present in the alimentary and the CNS. It is the most abundant peptide in the brain. CCK has been implicated in a number of disorders. The link between CCK and anxiety was the basis for this research. A comprehensive discussion on the many types of CCK …
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The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
Systemic administration of the CCK-A receptor antagonist lorglumide has been shown to block voltammetrically detected dopamine (DA) signals associated with slow wave depolarization (SWD) in the rat caudate (CPu). Failure to elicit KC1-induced DA signals following lorglumide treatment may be due to …
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Cholecystokinin Action at CCK1 Receptors in the Brain to Produce Satiety in Rats
Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist devazepide increases food intake in a variety of species provide compelling …
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RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation
… As a member of the GPCR superfamily, Cholecystokinin-2 receptor (CCK2R) is a physiological receptor for gastrin (G17) and activates extracellular signal-regulated kinase (ERK) via the PKC activity. The inhibition of classical PKCs (cPKC, PKC-α,-β, and -γ) by Gö6976 …
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Interactions of islet hormones with acetylcholine and cholecystokinin-octapeptide in the isolated pancreas of normal and diabetic rats
… acetyicholine (ACh), the gut hormone cholecystokinin octapeptide (CCK-8), sodium nitroprusside (SNIP), 8-Bromo guanosine 3'5' cyclic monophosphate (8-Br cOMP) and nerve stimulation on amylase secretion and intracellular free calcium concentration ([Ca 2 ]) in the isolated pancreas of …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΠΑΡΕΝΤΕΡΙΚΗΣ ΧΟΡΗΓΗΣΗΣ ΛΙΠΩΝ, ΑΜΙΝΟΞΕΩΝ ΚΑΙ ΥΔΑΤΑΝΘΡΑΚΩΝ ΣΤΗΝ ΣΥΣΠΑΣΤΙΚΟΤΗΤΑ ΤΗΣ ΧΟΛΗΔΟΧΟΥ ΚΥΣΤΕΩΣ
… VOLUME (GBV) AS WELL AS IN THE PLASMA LEVEL OF CHOLECYSTOKININ 90 MIN AFTER THE INITIAL ADMINISTRATION. THE STUDY WAS CARRIED OUT ON 29 INDIVIDUALS. THE CHANGE IN THE GBV WAS DETECTEDBY ULTRASOUND ASSESMENT AND THE PLASMA LEVEL OF CHOLECYSTOKININ ESTABLISHED BYRADIO IMMUNOASSAY STUDIES AT …
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New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors
… increased levels of neurotransmitters such as cholecystokinin (CCK) in which both the peptides and their receptors are increased in pain states. To effectively treat diseases involving "systems changes" a new paradigm for the design of compounds was proposed. In this new approach single peptide …
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Effets d'une immunomodulation de la leptine et de la cholécystokinine chez le rat en croissance
… The meal-related intestinal signal cholecystokinin (CCK) and the adipose tissue-produced leptin are known as satiety hormones. Their interaction induces long- and short-terms effects. The aim of this study is to examine the zootechnical and endocrinal effects of an active …
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Prevention of Acute Pancreatitis by Broccoli Components
… inhibition of nuclear factor-kappaB (NF-kappaB). Cholecystokinin (CCK)-induced acute pancreatitis is the most widely used in vivo experimental model, with a similar inflammation profile to acute pancreatitis in humans. Administration of crambene (1-cyano-2S-hydroxy-3-butene, CHB) to male F344 rats …
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An investigation of the distribution of gastrin-like activity, and its nature, in the gastrointestinal tract of the sheep
… The active principle was unlikely to have been cholecystokinin as the extracts had isoelectric points of a more acidic nature than that of cholecystokinin. Similarly, bioassay using an isolated guinea-pig ileum showed histamine to be absent from the extracts. Extraction of rumenal, reticular, …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
… in the cerebellum of the peptide hormone Cholecystokinin (Cck) in these mice. Knocking out Cck or the Cck1 receptor (Cck1R) in ATXN1[30Q]D776 mice confers a progressive disease where PC death occurs by thirty-six weeks of age. Weighted Gene Co-expression Network Analysis (WGCNA) performed …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… and gastric inhibitory peptide (Chapter 4), and cholecystokinin (Chapter 5) following nutrient stimulation. As intestinal tissue is a more complex and invasive matrix to collect, organoid models have been developed for *in vitro* studies of specific cell activity. An extraction method for …
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ΑΝΟΣΟΚΥΤΤΑΡΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΤΟΥ ΑΓΓΕΙΟΚΙΝΗΤΙΚΟΥ ΠΟΛΥΠΕΠΤΙΔΙΟΥ ΤΟΥ ΕΝΤΕΡΟΥ, ΤΗΣ ΧΟΛΗΚΥΣΤΟΚΙΝΙΝΗΣ ΚΑΙ ΤΟΥ ΝΕΥΡΟΠΕΠΤΙΔΙΟΥ Υ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ, ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP)-, CHOLECYSTOKININ (CCK)- AND NEUROPEPTIDE Y (NPY)- CONTAINING NEURONS IN THE CNS OF THE HEDGEHOG AND SHEEP, WERE INVESTIGATED USING AN IMMUNOCYTOCHEMICAL METHOD. A TOTAL OF THIRTY-TWO HEDGEHOGS AND TWENTY-FOUR SHEEP OF BOTH SEXES WERE USED. FROZEN …
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