Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Cholangitis"”.
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Primary sclerosing cholangitis
… six consecutive patients with primary sclerosing cholangitis (PSC), 20 males median age 42 years, were studied in order to define prognostic variables and determine the influence of surgery on outcome. Presentation was usually with insidious cholestasis or recurrent cholangitis. Twenty six …
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Primary sclerosing cholangitis: from genetic risk to disease biology
Primary sclerosing cholangitis: from genetic risk to disease biology Elizabeth Claire Goode One in 10,000 people in the Western world lives with Primary Sclerosing Cholangitis (PSC), an immune-mediated, inflammatory disease of the bile ducts that is highly co-morbid with inflammatory bowel disease …
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Primary biliary cholangitis: genetic risk, phenotypic stratification and disease pathogenesis
Primary biliary cholangitis (PBC) is a rare disease which occurs in fewer than 1 in 2,000 people, mainly women over the age of 40. It is an autoimmune condition and is phenotypically associated with other immune-mediated inflammatory disorders (IMIDs). It is characterised by progressive destruction …
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ROLE OF NATURAL KILLER CELLS IN THE PATHOGENESIS OF PRIMARY BILIARY CHOLANGITIS
Background: Primary biliary cholangitis (PBC) is the most prevalent autoimmune liver disease and involves the selective destruction of small intrahepatic biliary epithelial cells (BECs), potentially leading to biliary cirrhosis and liver transplantation, if left untreated. As of now, …
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Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a progressive chronic cholestatic liver disease, affecting young males predominantly. It causes stricturing of the intrahepatic and extrahepatic bile ducts, often leading to biliary cirrhosis, with an increased risk of colorectal and hepato-biliary …
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Der enterohepatische Kreislauf von T-Lymphozyten für die Entwicklung einer immunvermittelten Cholangitis bei chronisch entzündlichen Darmerkrankungen
Die Primäre sklerosierende Cholangitis (PSC) ist eine chronisch rezidivierende Entzündung der extra- und intrahepatischen Gallengänge bislang unbekannter Ursache, welche eng mit einer chronischen Kolitis assoziiert ist. Dabei weisen die in der Leber von PSC-Patienten vermehrt vorkommenden T-Zellen …
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Maligner Verschlussikterus : eine retrospektive Analyse der Komplikationen und Ergebnisse der nicht-operativen Gallendrainage
… Galle führte nur bei 19,7 der Pat. zu einer Cholangitis, so dass mehrere Faktoren eine Rolle spielen müssen, damit es zu einer Cholangitis kommen kann. Besonders Pat. mit einem Gallengangskarzinom sind am häufigsten gefährdet. Als weitere Komplikationen kamen ein Leberabszess, ein …
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Salivary proteome investigation for Autoimmune Liver Diseases classification and biomarker discovery
… Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC), and Primary Sclerosing Cholangitis (PSC). Saliva, as a mirror of oral and systemic health, represents a promising biofluid for biomarker discovery. Several studies evidenced that various systemic disorders affected qualitatively …
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MAdCAM-1 expression and function in human liver
… in liver diseases such as primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) that complicate IBD, therefore understanding the factors that drive hepatic expression of MAdCAM-1 might elucidate the pathogenesis of these diseases. In vitro stimulation of HSEC with tumor necrosis …
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Elucidating the biology of G-protein coupled receptor 35
… a coding variant is linked to primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen short of revealing its core biology. In this project we set out to gain further understanding of the biology …
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Which pre-operative findings translate to a positive intra-operative cholangiogram?
… cholecystitis, and one case was for ascending cholangitis. Four cases had a positive IOC, and in this group, the median age was 44.5 years with one male. The mean common bile duct diameter was 6.5 mm. Two patients had biliary colic, one patient gallstone pancreatitis and one acute …
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Chronic hepatitis at Groote Schuur Hospital: 1978-1996 : a literature review of the syndrome, its clinical spectrum and management at Groote Schuur Hospital
… Primary biliary cirrhosis, Primary sclerosing cholangitis, alpha-1-antitrypsin deficiency, alcohol abuse and iron over load states.
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Machine learning and data analytics for liver disease modeling
Primary sclerosing cholangitis (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective …
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Factors affecting recurrence of intrahepatic duct stone and factors affecting development of cholangiocarcinoma after initial treatment of intrahepatic duct stone
Background Hepatolithiasis causes recurrent cholangitis, biliary cirrhosis, and is an important risk factor for cholangiocarcinoma, which has a grave prognosis. Nevertheless, its intractable nature and high recurrence rate complicates treatment. Therefore, we investigated factors affecting …
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The function of TAK1 in hepatocarcinogenesis
… suffer from advanced hepatitis and an acute cholangitis at the age of 6 weeks, leading to enhanced mortality rate between 14 and 36 weeks of age. We showed that TAK1 prevents liver cell apoptosis and hepatic inflammation since it is necessary for NF-kappaB activation but not JNK activation in …
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Clinical, Diagnostic, Therapeutic and Prognostic Aspects of Autoimmune Liver Diseases /// Клинико-диагностични, терапевтични и прогностични аспекти на автоимунните чернодробни болести
Темата на дисертацията е свързана със сравнително редките автоимунни болести на черния дроб – автоимунен хепатит (АИХ), първичен билиарен холангит (ПБХ), първичен склерозиращ холангит и наслагващи се синдроми. За първи път у нас е извършена цялостна характеристика на автоимунните чернодробни …