Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Cholangiocyte"”.
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The Immunogenicity of Cholangiocyte Cellular Therapies
Cholangiocytes are the epithelial cells of the biliary system, responsible for the transport and modification of bile. Cholangiocyte disorders, known as cholangiopathies, are a diverse group of life-threatening conditions characterised by cholestasis, ductopenia and eventual liver failure. There …
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The role of the mechanical microenvironment in regulation of cholangiocyte specification and tubulogenesis
… formation, emphasising collagen I’s role in both cholangiocyte fate specification and morphogenesis. Together, my findings reveal how cell-ECM interactions are a primary regulator of biliary epithelial cell fate specification and morphogenesis. This work, to my knowledge, is the first to …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… this challenge, I use biliary epithelial cell (cholangiocyte), one of the cell types with the highest ACE2 levels, to dissect the molecular mechanisms controlling ACE2 expression. I identify the farnesoid X receptor (FXR) as a direct regulator of ACE2 transcription in multiple COVID19- affected …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
… of interest is the transdifferentiation of cholangiocytes into hepatocytes via either direct differentiation or via a progenitor cell population (Michalopoulos & Khan, 2015). However, the reality of this process in a disease context especially in human remains to be fully demonstrated while …
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Investigation of growth factors and cytokines that suppress adult stem cell asymmetric cell kinetics
… have used the SACK method to derive hepatic and cholangiocyte stem cell strains from adult rat livers in vitro. These cell strains provide an assay to evaluate whether growth factors and cytokines previously implicated in proliferation of progenitor cells act by converting the kinetics of the …
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Modelling human liver bud development in vitro
… (KRT19+CDX2+PDX1+HNF1B+) and extra-hepatic cholangiocytes (ACE2+MUC13+). By performing extensive snRNAseq analyses across HepBud formation, I was able to validate that hepatic specification in HepBuds follows a natural developmental path forming hepatoblast which strongly resemble 5/6pcw …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… non-malignant murine biliary epithelial cells (cholangiocytes, 603B cells) and human lung epithelial carcinoma cells (A495 cells). We examined collagen production and cell survival in 603B cells and cell migration in A549 cells during TGF-β1-induced EMT. The involvement of Snail1 in mediating …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
The cellular microenvironment encompasses every chemical and physical factor surrounding a cell, including all other cells, cell-cell and cell-extracellular matrix (ECM) signaling interactions and any detectible change in conditions. As the interplay between every component of the microenvironment …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
Engineered systems provide a means of deconstructing the microenvironmental cues which guide cell fate and function. These cues can include biochemical elements, as in ligand–receptor binding for cell–cell or cell–extracellular matrix (ECM) interactions, or responses to biophysical parameters, as …