Global ETD Search
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Showing 1 to 3 of 3 for “"Chlorzoxazone"”.
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The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys
… brain tissue. Also, in vivo pharmacokinetics for chlorzoxazone (metabolized selectively by CYP2E1) and nicotine (metabolized primarily by CYP2A6 and to a lesser extent CYP2B6) were assessed. Hepatic CYP2E1 protein levels, in vitro hepatic CYP2E1 activity and in vivo chlorzoxazone metabolism were …
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Human Cytochrome P450 2E1: Functional Comparison to Cytochrome 2A13 and 2A6
… CYP2E1 substrates p-nitrophenol (pNP) [2] and chlorzoxazone (CZN) [3], but none showed significant differences in activity from the CYP2E1 wild type enzyme. However, in contrast to previous literature reports [4], both CYP2A6 and CYP2A13 were observed to metabolize both CYP2E1 substrates pNP …
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The Role of Cytochrome P450 2E1 in Hepatic Ischemia Reperfusion Injury and Reactive Oxygen Species Formation
… determined by UPLC-MS/MS analysis of 6-hydroxychlorzoxazone formed from the chlorzoxazone substrate. The CYP2E1 and Control clones were subjected to hypoxia (10 h) and reoxygenation (0.5 h), and cell death and ROS generation were quantitated using LDH and flow cytometry, respectively. Compared …