Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Chlorpheniramine"”.
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Using high resolution mass spectrometry to profile impurities in drugs from different sources
… verified. In chapter 4 the organic impurities in chlorpheniramine maleate were investigated using high resolution mass spectrometry in combination with chemometric modelling of the data. Several new impurities of chlorpheniramine maleate were characterised by using MSn and it was demonstrated that …
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Development of screening assays to test novel integrin antagonists in allergic inflammation
… mM), but not the first-generation antihistamine chlorpheniramine, displaces [125I]fibronectin (FN) binding to human a4b1 integrin. This result is supported by flow cytometry analysis, where levocabastine antagonizes the binding of a primary antibody to integrin a4 expressed in Jurkat E6.1 cells. …
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Evaluation of antihistamines for in vitro antimalarial activity against Plasmodium falciparum
… Promising results have been demonstrated when chlorpheniramine was combined with chloroquine to reverse chloroquine resistance in two African studies (Sowunmi et al, 1997; Abok., 1997).Recently, astemizole and its principle human metabolite desmethylastemizole were identified as potent …
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A Series of Pharmaceutical Technology Concepts Applied to Pediatric Formulations
… and an anion were utilized in this work (Chlorpheniramine Maleate, Prednisone, Sulfamerazine, and Iodide ion). Each drug molecule was utilized according to its physicochemical properties along with the pediatric patients’ needs. As a result, several pediatric formulations were developed. …
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The production of a lyotropic liquid crystal coated powder precursor through twin screw extrusion.
… granular aggregates. The highly soluble chlorpheniramine maleate loaded in Pluronic F127 solution coated MCC particles prepared through twin screw extrusion was examined to produce the cubic phase (gel) for the development of controlled release formulation and for coating of very fine …
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Developments in Raman spectrometry and intracavity laser absorption spectrometry for quantitative analysis
… study, an HPLC method was devised to quantify chlorpheniramine maleate (the API) in a sample set of more than 280 Chlortrimeton allergy tablets containing a stated API mass of 4 mg. Despite utilising a multi-stage, destructive sample preparation sequence, the average calculated API mass was …
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Investigations into the roles of Histamine Receptor H1 and extracellular vesicles in ovarian cancer cell behaviour
… activation (via histamine) or inhibition (via chlorpheniramine) and its effect on cellular behaviour was evaluated through different in vitro assays. Results showed that HRH1: 1) does not modulate gene expression of EMT-related genes; 2) does not influence adhesion of OC cells to endothelial …
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Toxicological Findings in Fatal Road Traffic Accidents in Cape Town: A Pilot Study
… if consumed therapeutically, such as codeine, chlorpheniramine, diphenhydramine and zopiclone. Discussion: This study was the first to the author’s knowledge to report on prospective toxicological findings in road traffic accident cases in Cape Town. Although this was a pilot study, the results …
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… form III. Xylitol exhibited good processability. Chlorpheniramine Maleate (CLPM) and Diltiazem Hydrochloride (DTZ) were used as a model API to design a sustained release pellet formulations utilizing Ethocel<sup>TM</sup> (EC). EC is also studied as matrix former with lipophillic processing aids …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… MAP design and performance. Two antihistamines—chlorpheniramine maleate (CPM) and loratadine (LOR)—were incorporated into MAP using distinct micromoulding methods (drug solution diffusion vs molten drug) and formulation types (polymer-based vs drug-only). The final formulations, CPM MAP (70 …
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Methods for removing pharmaceuticals from human urine
… a high pH (˃12), was 0 - 64.7%. Diclofenac and chlorpheniramine maleate did not degrade, while salicylic acid experienced the most degradation (64.7%). On the other hand, the ARVs had a range of degradation of 17.2 - 73.4%. Stavudine experienced the least degradation (17.2%) while lamivudine …