Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Chlorotoxin"”.
-
The mechanism of action of the scorpion toxin, chlorotoxin, a bioinformatics approach
… potential targets for effective glioma therapy. Chlorotoxin is a promising toxin peptide for glioma targeted therapy. Chlorotoxin decreased migration and metastasis of GBM cells, although mechanism of action of the toxin is unclear due to the complicated nature of GBM, slow and costly experiments …
-
Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… and characterize GBM is one such strategy. Chlorotoxin (Ctx), a 36-amino-acid residue polypeptide derived from Leiurus quinquestriatus scorpion venom, has shown selective binding to GBM cells, making it a promising candidate for diagnostic applications and improving tumor visualization. …
-
Engineering M13 bacteriophage platforms for cancer therapy applications
… targeting M13 platform collection by cloning for chlorotoxin display on the tail p3 capsid protein of M13. Chlorotoxin can induce passage across blood-brain barrier, targets for cancer cells, and specifically internalizes to glioma cells. Expression of chlorotoxin on M13 will allow us to …
-
Engineering M13 Bacteriophage Nanoplatforms for Diagnostic and Therapeutic Applications
… phage derived particles, (ii) developed a chlorotoxin (CTX) motif on the M13 p3 capsid to enable phage particle crossing of the blood-brain-barrier and homing to glioblastoma cancer cells, and (iii) built ‘inho’ phage derived transgene cassettes for phage gene delivery in mammalian cells. …
-
CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… to characterize<em> in vitro </em>specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of <em>e</em>xtracellular <em>m</em>atrix <em>m</em>etalloproteinase <em>in</em>ducer (EMMPRIN; Basigin) isoform 2, toward U87 GBM …
-
Improving efficacy of therapeutics by enhancing delivery using chemical engineering
… We found that conjugates of siRNA with chlorotoxin could knock down levels of a housekeeping gene in vitro and in vivo in a mouse brain tumor model. Furthermore, we developed prostate-cancer targeting ligands that demonstrate in vitro efficacy and tested them in vivo.
-
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) based diagnostic and therapeutic applications. Bimetallic gold-platinum …
-
Multifunctional Nanoparticles for Cancer Imaging and Therapy
… cells. Conjugation of glioma-targeting peptide chlorotoxin on the nanoparticle improved the cellular uptake of the siRNA, and polyarginine peptide on the nanoparticle enhanced the endosomal escape of the siRNA into the cytosol. The efficiency of gene silencing was found to be greatly enhanced …