Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Chloroquine resistance"”.
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The Use of Combinations of Chemosensitisers to Reverse Chloroquine Resistance in Mice infected with Malaria
… compounds are able to transiently alter chloroquine resistance via chemosensitisation, the phenomenon has never evolved beyond laboratory practice as a result of in vivo difficulties. Chemosensitising compounds either need to be administered at doses which are toxic to the host in order …
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An investigation of privileged substructural motifs as templates for the discovery and design of chloroquine-resistance reversal agents
Includes bibliographical references (leaves 152-165).
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The antimalarial activity of Dicoma anomala and the chloroquine resistance reversing effects of Sclerocarya birrea on Plasmodium falciparum in vitro
… selectively enhance the in vitro accumulation of chloroquine in resistant strains of Plasmodium falciparum.
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Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and …
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Evaluation of antihistamines for in vitro antimalarial activity against Plasmodium falciparum
… activity and cause a marked reversal of chloroquine resistance in vitro and in vivo. Promising results have been demonstrated when chlorpheniramine was combined with chloroquine to reverse chloroquine resistance in two African studies (Sowunmi et al, 1997; Abok., 1997).Recently, …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
Antimalarial drug resistance is a major factor affecting global malaria control, causing treatment failure and significant morbidity and mortality. Resistance has historically emerged in low-transmission areas before spreading to high-transmission areas, and there is consequently widespread …
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Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains
Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance proteins might be involved in the mechanism of resistance. …
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The occurence, distribution and frequency of membrane transporter resistance alleles in <i>Plasmodium falciparum</i> and their association with response and resistance to Arteminisin based combination therapy (ART) in Northern Nigeria
… genome has shown to have recently developed resistance to the most successful related group of drug treatment, known as Artemisinin combination therapies (ACTs), primarily in parts of South East Asia, but possibly also in other parts of the world e.g. East Africa.<br/>The purpose of this …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
<p>Multidrug resistance (MDR) is the condition where cancer cells or microorganisms cease to respond to multiple drugs. MDR conferred by efflux transporters, that deprive the bioavailability of drugs at their site of action, are a threat to cancer and malarial chemotherapy. Specifically, the …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
Antimalarial drug resistance is an unrelenting obstacle to malaria control programs. In Southeast Asia (SEA), parasites have developed some degree of resistance to nearly every malaria drug currently available, with the most recent emergence to artemisinin combination therapies (ACTs). ACTs are the …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… severe forms of human malaria; with multidrug resistance to modern antimalarials emerging and spreading in certain parasite populations, understanding the mechanisms for acquiring multidrug resistance will be key for predicting which genes may become important for clinical resistance in the …
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Investigating calcium channel blockers as antimalarials
The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as …
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Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS)
… well as the modes of action of antimalarial drug resistance. We have developed a computational pipeline that converts a series of fluorescence readings from a DNA microarray into a meaningful set of biological hypotheses based on the comparison of two lines, generally one that is drug sensitive …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
The recurring challenge of the emergence of drug resistance necessitates the continual development of improved antimalarial treatments, which can target parasite strains that display reduced susceptibility towards current therapy. Consequently, a novel series of dual functioning pyridodibemequine …
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In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
… one focus for researches in response to the resistance of P. falciparum malaria parasites that emerged towards well-known antimalarials. While hundreds of new β-haematin inhibitors have been discovered using detergent mediated high-throughput screening methods, a crucial aspect is …