Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Chloride channel"”.
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… transporters that function as Ca2+-dependent Cl- channels (CaCCs) or dual functional Ca2+-dependent ion channels and phospholipid scramblases. The TMEM16A and TMEM16B CaCCs conduct Cl- across the membrane and regulate transepithelial fluid transport, smooth muscle contraction, neuronal …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… airway remodeling. TGF-β activity also affects chloride channel activity, which can regulate mediator release and cell migration. Therefore,the role that TGF-β1 stimulation of eosinophils has on chloride channel activity and migration of eosinophils and the underlying mechanisms involved in this …
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… Hco-UNC-49 is a H. contortus GABA-gated chloride channel and is an orthologue to the UNC-49 channel from the free-living nematode Caenorhabditis elegans. Previous research by our group has shown that while the UNC-49 channels from the two nematodes share similar sequence homology they do …
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Chloride Channel 3 (CLC3), an Immune Antiporter in the Migration and Activation of Human Eosinophils in Allergic Asthma
… has also been implicated in the modulation of chloride channels including CLC3, which is required for the respiratory burst by eosinophils and neutrophils, and altering the shape to cause migration of neutrophils. However, the underlying mechanism of eosinophil migration and activation is not …
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A molecular characterization of agonists that bind to Hco-UNC-49, a GABA-gated chloride channel from Haemonchus contortus
… control. UNC-49 is a nematode ligand-gated ion channel that plays an important role in muscle contraction required for normal locomotion. However, little is known regarding its sensitivity to different agonists and how they interact with the binding site. This thesis describes an investigation …
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Ion Transport in Chloroplasts with Role in Regulation of Photosynthesis
… the rest of the cell, specialized proteins named channels and transporters mediate ion transport across membranes and control ion homeostasis in chloroplasts. The work presented in this thesis addresses the role in regulation of photosynthesis of ion channels and transporters from the chloroplast …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… an alarming rate. Cystine-loop ligand-gated ion channels are important receptors in nematode neurobiology, and as such are promising drug targets. The UNC-49 (GABA-gated chloride channel) and ACC (acetylcholine-gated chloride channel) family of receptors have been characterized as potential drug …
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Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans
… NPR-9 and stimulatory glutamate gated cation channel receptor GLR-1 function in anterior interneuron AIB. npr-9 loss-of-function and over-expression mutants display abnormal spontaneous locomotion patterns. Hence, we evaluated npr-9 and AIB-specific glr-1 mutant locomotory phenotypes in …
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Chloride Channels in Normal Human Blood Monocytes and a Macrophage-like Cell Line
… and volume change are unclear.|Alteration in ion channels, especially chloride channels, is generally involved in the shape and volume change of circulating cells for successful invasion into tissues. In this work, we examined chloride currents in human blood monocytes and macrophages, and their …
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Nongenomic Effects of Estrogens on Epithelial Chloride Secretion.
… cell line T84, a model for studying epithelial chloride secretion and cystic fibrosis chloride channel (CFTR) function, was used to investigate the regulatory role of estrogens in transepithelial ion transport. Estrogens and other steroid hormones do not stimulate chloride secretion by …
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
… interest, ACC-2 which is an acetylcholine-gated chloride channel unique to nematodes and the UNC-49 GABA receptor. In total, 22 compounds, 12 of which are novel, were synthesized, including imidazole-4-acetic acid like compounds, levamisole derivatives, and a levamisole dimer. Compounds 8-15 were …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… that can regulate cAMP-/cGMP-activated CFTR chloride channel function. We report the physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation …
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Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
… by several nematocides which target ion channels. We have identified two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B subunit forms a functional homomeric channel in Xenopus …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… fluid are controlled by the activity of ion channels and transporters. In cystic fibrosis (CF), loss of CFTR chloride channel function causes airway surface dehydration, bacterial infection, and inflammation. We investigated the effects of IL-17A plus TNF-α, 2 cytokines with relevant roles in …
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
… cattle, sheep, and goats. UNC-49 is a GABA-gated chloride channel found to be exclusive to nematodes which could be a viable future target for anthelminthic drugs. An analysis of the model of the Hco-UNC-49 receptor has identified potentially interacting residues that may be important to its …
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
Chloride channels play an essential role in the physiology of the respiratory system, the gastrointestinal tract, and secretory glands. Their dysregulation underlies debilitating pathologies such as cystic fibrosis, asthma, and certain cancers. The CLCA (Chloride Channel Accessory) gene family is …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
… targeting gamma-aminobutyric acid (GABA)-gated chloride channels, indicating the potential of insect mAChRs as a target for developing novel insecticides/synergists to control resistant pests. A point mutation (A301S) in the GABA-gated chloride channel confers resistance to dieldrin (Rdl), …
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Distribution and targeting of CLC-3
ClC-3 is a ubiquitously expressed chloride channel that is present in synaptic vesicles and endosome/lysosome compartments. The channel is largely intracellular, but has been observed at the plasma membrane as well. The aim of this study was to identify the trafficking pathway for delivery of ClC-3 …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their proximity to each other in a …
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