Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Chiral separation"”.
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Spontaneous symmetry breaking transport : from anomalous response to chiral separation
… to sort molecules that differ only by their chirality,published in [5]. Using spontaneous breaking of chiral symmetry, the two chiral partners can be directed into orthogonal directions under the influence of a constant bias force in a symmetry direction of the lattice and into opposite …
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The Effects of Methanol and Isopropanol on the Chiral Separation of Dronabinol and Three Related Impurities: A 3 X 3 X 3 Factorial Design
The enantioseparations of Δ9-THC and Δ8-THC on amylose tris dimethylphenylcarbamate CSP was investigated using mobile phases containing 1-3% methanol with 1-7% IPA in n-heptane. A factorial design was used to study the main and interaction effects of these alcohols as measured by the retention …
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Expert system shells in chemistry: CHIRULE, a chiral chromatographic column selection system using similarity searching and personal construct theory
… process of selecting a column to perform a chiral separation can be characterized as more of an art than a science. This dissertation describes CHIRULE, a "chromatographic assistant" to aid in developing chiral separations. CHIRULE constructs an n-dimensional information space from a large …
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Tuning polymeric chiral surfactants for enhanced enantiomeric recognition in micellar electrokinetic chromatography
… The effect of polydispersity of poly-L-SUL on chiral separation of compounds was also examined. Centrifugal filtration was used to fractionate the polymeric surfactant into different molecular weight distribution. The resulting fractions were characterized by use fluorescence, PFG-NMR, …
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Lattice QCD Study of Anomalous Transport Phenomena in Strongly Interacting Matter
In this thesis, we study the Chiral Magnetic Effect (CME) and the Chiral Separation Effect (CSE) using lattice QCD simulations. We completely characterize the CSE in QCD using $2+1$ simulations of staggered quarks tuned at the physical point. We find that the CSE conductivity is severely suppressed …
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Capillary Zone Electrophoresis Studies of Sulfur Containing Compounds
… CZE offers an unprecedented advantage in that separations can be employed for speciation or quantitation of complex mixtures by using the appropriate standards or specific detectors. For the study, model sulfonium and thiophenium ions were used to determine the feasibility of the separation and …
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The design and synthesis of mixed ligand metal organic frameworks for xylene inclusion
… owing to its great promise in the areas of separation of small molecules, sensors, and chiral separation. The term ‘inclusion compounds’ refers to the association between large compounds (host) that is able to enclose a smaller molecule (guest). This association utilizes non-covalent …
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DEVELOPMENT OF A NEW CHIRAL MONOLITHIC CAPILLARY COLUMN AND A FLUORESCENCE SPECTROSCOPIC STUDY OF A SELECTIVE OFF-ON PET SENSOR FOR THE DETECTION OF ZINC IONS
… monolithic silica gel as a column substrate for chiral separation by covalently modifying with (S, S)-Whelk-O1 chiral selector. The monolithic stationary phase was generated through a sol-gel process and prepared in situ in a 100 µm i.d. fused silica capillary tubing. The chromatographic …
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Higher-Order Assemblies of Flavin-Wrapped, Single-Walled Carbon Nanotubes
… lack the uniformity of nanotube diameters and chiralities required of many device-driven applications. Accordingly, one of the most pressing challenges facing the field of carbon nanotube research is the ongoing effort to isolate single chirality nanotubes. In 2008, Ju and Papadimitrakopoulos …
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Chromatographic studies and analytical methods development for selected tetraazamacrocycles and their copper(II) complexes
… and therapeutic agents. The development of separation conditions is important in evaluating their purity as well as assessment of their physical properties including conditional formation constants, acid dissociation constants and lipophilicity, which can have a major bearing on the in vivo …
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Biofunctionalization of Submicrometer Pores and Mass Limited Sample Manipulations in Three-Dimensional Hybrid Microfluidic/nanofluidic Devices
… are molecular recognition, multidimensional separation, online sample preconcentration, as well as analyte sorting and concentration which uses the nanofluidic components interconnecting the spatially separated microfluidic channels. First of all, molecular recognition is realized by …
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Analytical separations using packed and open-tubular capillary electrochromatography
… electrochromatographic methods for improved achiral and chiral separations of various classes of analytes. The first part of this research involves the separation of seven benzodiazepines by the use of the packed mode of capillary electrochromatography (CEC) and a 40 cm packed bed of Reliasil …
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Rapid separation of biologically important low molecular weight compounds by microchip electrophoresis and ultra-fast performance liquid chromatography
The research work in this thesis reports rapid separation of biologically important low molecular weight compounds by microchip electrophoresis and ultrahigh liquid chromatography. Chapter 1 introduces the theory and principles behind capillary electrophoresis separation. An overview of the …
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Applications of Green Chemistry in Asymmetric Transfer Hydrogenation and Chiral Separations
… chemistry. More specifically, allylic and chiral alcohols are abundant in natural sources such as in essential oils, and widely utilized as starting materials. They are also major components in food, fragrance, biocides and the pharmaceutical compounds. In this thesis, I report the first …
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Chiral Separations on HPLC Derivatized Polysaccharide CSPs: Temperature, Mobile Phase and Chiral Recognition Mechanism Studies
Direct chiral separations of the non-steroidal drugs of 2-methylarylpropionic acids (profens) on the chiral stationary phases (CSPs) of amylose tris(3,5-dimethylphenyl-carbamate), Chiralpak AD, and cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, were investigated. Chiralpak AD and …
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Analysis of endogenous D-amino acids in the central nervous system and endocrine system via capillary electrophoresis with biochemical sample treatment
Chirality has significant functional effects in biological system including the central nervous system. Due to their unique chirality, endogenous D-amino acids are considered to play different roles from their corresponding L-isomers. In the central nervous system, a few D-amino acids have been …
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Migration and separation in structured microfluidic systems
… in modern (bio-)analytics: the usually fixed separation criterion (e.g. a gel density is not changeable on the fly), the usually unknown polarizability properties of samples for dielectrophoretic manipulation and the requirement of a specifically designed chiral selector for chiral separation. …
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Synthesis and enzymatic resolution of amino acid esters in "green" solvents -- ionic liquids
Chiral separation has attracted tremendous attention in pharmaceutical and chemical fields, especially in the area of chiral drug development. Chiral amino acids are among the most important intermediates in the asymmetric synthesis of modem drugs. This research has developed an effective method …
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Measuring D-amino acids in the central nervous system using capillary electrophoresis
… complex neuronal microenvironment, accomplishing chiral separations and quantifying low abundant D-AAs reliably. Among D-AAs found across the metazoan, two D-AAs are studied extensively, namely D-serine (D-Ser) and D-aspartate (D-Asp). D-Ser can be synthesized endogenously by serine racemase which …
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Chiral resolution control in batch and continuous crystallization processes for a conglomerate forming compound
Chiral molecules are molecules that have a non-superimposable mirror image. Each of these mirror image forms is known as an enantiomer. Such molecules exist throughout nature, from amino acid and sugar molecules, to the complex helical structure of our own DNA. However, the separation of …
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