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Showing 1 to 6 of 6 for “"Chiral discrimination"”.
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Studies on new approaches of chiral discrimination for chiral analysis by regression modeling of spectral data.
Two new approaches of chiral discrimination for enantiomeric composition analysis using isotropic spectroscopic techniques and multivariate regression modeling were investigated. This is in view of the urgent need for rapid and improved strategies for chiral analysis due to the rising preference …
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An investigation into the use of B-cyclodextrins as additives to effect enantiomeric separation by reversed phase HPLC.
The occurrence of chirality in organic molecules and its significance for the clinical effects of drug molecules is reviewed. A need is established for suitable methods, both analytical and preparative for the separation of enantiomers. The present range of analytical methods used for …
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Applications of Brush-Type Chiral Stationary Phases in New Chromatographic Techniques
… are an important class of resolutions by which a chiral stationary phase (CSP) is utilized to affect the separation of a mixture of enantiomers to provide, as the end result, the single enantiomers of the mixture. In the studies described within, three areas involved in chiral discrimination are …
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Chiral Separations on HPLC Derivatized Polysaccharide CSPs: Temperature, Mobile Phase and Chiral Recognition Mechanism Studies
Direct chiral separations of the non-steroidal drugs of 2-methylarylpropionic acids (profens) on the chiral stationary phases (CSPs) of amylose tris(3,5-dimethylphenyl-carbamate), Chiralpak AD, and cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, were investigated. Chiralpak AD and …
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Exploring the Functionality and Application of Cyclic Phosphazanes
… active ligands for inorganic electrolytes, and chiral discrimination reagents for enantiomeric amines were explored. Firstly, the extensive versatility of cyclodiphosphazanes in synthesising P(III), P(V), or mixed-valence inorganic macrocycles is demonstrated in this thesis. Despite many of the …
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Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers
… self-assembly approach with a high level of chiral discrimination to construct Janus dendrimers in situ. As far as we are aware, this is the first such example utilizing metal-ligand interaction for the construction of Janus dendrimers. Using this approach we were able to generate a large …