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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Chiral Separations"”.
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Applications of Green Chemistry in Asymmetric Transfer Hydrogenation and Chiral Separations
… chemistry. More specifically, allylic and chiral alcohols are abundant in natural sources such as in essential oils, and widely utilized as starting materials. They are also major components in food, fragrance, biocides and the pharmaceutical compounds. In this thesis, I report the first …
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Thermodynamic and kinetic investigation of chiral separations using polysaccharide stationary phases
Thesis (Ph. D.)--Michigan State University. Dept. of Chemistry, 2010
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Characterization of endogenous D-amino acids in mammals via chiral separations
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Chiral Separations on HPLC Derivatized Polysaccharide CSPs: Temperature, Mobile Phase and Chiral Recognition Mechanism Studies
Direct chiral separations of the non-steroidal drugs of 2-methylarylpropionic acids (profens) on the chiral stationary phases (CSPs) of amylose tris(3,5-dimethylphenyl-carbamate), Chiralpak AD, and cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, were investigated. Chiralpak AD and …
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Expert system shells in chemistry: CHIRULE, a chiral chromatographic column selection system using similarity searching and personal construct theory
… process of selecting a column to perform a chiral separation can be characterized as more of an art than a science. This dissertation describes CHIRULE, a "chromatographic assistant" to aid in developing chiral separations. CHIRULE constructs an n-dimensional information space from a large …
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New bio-analytical separations utilizing chiral mobile phase additives in thin layer chromatography and chiral stationary phases in high performance liquid chromatography
… important and rapidly developing field of study. Chiral separations of pharmaceutical compounds and important organic intermediates in high performance liquid chromatography (HPLC) and thin layer chromatography (TLC) were achieved. Two methods were employed for the direct liquid chromatographic …
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Analytical separations using packed and open-tubular capillary electrochromatography
… electrochromatographic methods for improved achiral and chiral separations of various classes of analytes. The first part of this research involves the separation of seven benzodiazepines by the use of the packed mode of capillary electrochromatography (CEC) and a 40 cm packed bed of Reliasil …
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Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
… did not focus on stereoselective syntheses or chiral separations, which in the case of the chiral tetrahydro-beta-carbolines could have given valuable insights about the spatial requirements for affinity among the three main opioid receptors.
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Fundamental Capillary Electrophoresis: An Evaluation of Electrokinetic Sampling
… separation technique in fields of biochemical separations, inorganic ions, and chiral separations. The technique has experienced exponential growth since the historic publication of Zone Electrophoresis in Open-Tubular Glass Capillaries by Lukacs and Jorgenson in 1981. However, the use of …
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Measuring D-amino acids in the central nervous system using capillary electrophoresis
… complex neuronal microenvironment, accomplishing chiral separations and quantifying low abundant D-AAs reliably. Among D-AAs found across the metazoan, two D-AAs are studied extensively, namely D-serine (D-Ser) and D-aspartate (D-Asp). D-Ser can be synthesized endogenously by serine racemase which …
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Methodological advances for the measurement of the D-amino acids across the metazoa: From mollusks to man
… amino acids, with the exception of glycine, are chiral molecules which exist as either L- or D-amino acids. Although identical with regard to physical and chemical properties, the enantiomeric forms rotate plane-polarized light in opposite directions. The difference in stereoconfiguration of D- …
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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… <em>in vivo</em> with the reduced necessity of chiral separations. Some of these new compounds have activity similar to Sorafenib, an FDA-approved drug that has been tested clinically in melanoma patients.</p> <p>To further expand our understanding of SARs and to potentially identify new …