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Showing 1 to 18 of 18 for “"Chimerism"”.
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… suggests that the presence of donor CD4 T cell chimerism in the peripheral blood of lung transplant recipients is a uniform phenomenon. Donor CD4 T lymphocytes were consistently detected in the recipients’ peripheral blood during the first post-operative month; however, the number of detectable …
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Chimerizmo analizė atskirose ląstelių populiacijose po alogeninės kraujodaros kamieninių ląstelių transplantacijos vaikams /
… to evaluate in a comparative way the benefit chimerism assessment in isolated cell populations (ICP) versus conventional monitoring in whole blood cells (WBC). The study was initiated in Pediatric Bone Marrow Transplant Service of Charité Children’s Hospital (Humboldt University, Berlin). …
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Human-Mouse Neural Crest Chimeras as a Novel Model for Human Melanocyte Biology in Development and Disease
… limits of the barriers restricting interspecies chimerism. Here we present approaches which focus on recapitulating the melanocyte neural crest lineage to pave the wave for a novel immune-competent melanoma model: First, we try adapting human donor cells to the mouse host environment via …
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Identification and Characterization of Distinct Populations of Clonogenic Bone Marrow Stromal Cells Capable of Transferring The Hematopoietic Microenvironment In Vivo and Supporting Lt-Hscs In Vitro
… donor repopulation with an average of 65+23.6% chimerism from CD105POS co-cultures and 49.3+19.5% chimerism from the CD105NEG co-cultures. However, we observed a significant difference when mice were transplanted with the progeny of a single co-cultured HSC. In these experiments, CD105POS …
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Platyrrhine Phylogenetics With A Focus On Callitrichine Life History Adaptations
… Goeldi's monkey was accessed though detection of chimerism and adaptive evolution of genes involved in reproduction. We determined based on these analysis that the reduction in litter size is likely pre-ovulation and due to a reversion to mono-ovulation in the species.</p>
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Variation in Recombination Rate on BTA23: Fine Mapping and Construction of a YAC Contig
… a somatic cell hybrid panel. The percentage of chimerism in this region was high (62%) in contrast to the previous estimate of 21% for this library. Estimation of the precise physical distance for the contig was not available due to a high proportion of clones being chimeric and to presence of …
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Overcoming skin rejection in composite tissue allotransplantation
… skin allotransplants. In utero and adult chimerism induction models are then used in an attempt to attain moderate-level chimeras. A vascularised skin allotransplant model is developed. Finally, the hypothesis is confirmed with the transplantation of a vascularised skin allotransplant on …
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Exogenous donor-derived hepatogenesis in chimeric hosts
… and limitations of intra and intererspecies chimerism in overcoming developmental barriers and achieving successful organogenesis. Building on these results, blastocyst complementation experiments were conducted in a large animal biomedical pig model lacking liver development (ahepatic pigs), …
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Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
… (but also LMPPs) as it allows higher levels of chimerism after IUHCT then after BMT in neonatal or adult age. In the last part we investigate in adult and fetal animal models the proposed plasticity of HSCs, a feature that holds promise for clinical BMT (or IUHCT) to non-hematopoietic disorders. …
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Donor lymphocyte infusion after allogeneic stem cell transplantation in children
… (CR)and 1 SAA patient recovered donor’s full chimerism. But other leukemia patient did not achieve CR and 4 of5 expired due to disease progression. The patient with Philadelphia gene positive ALL survived by imatinib mesylate maintenance therapy although failure of DLI. Overall, 4 of 8patients …
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Virtual microfluidics : a novel single-cell technology based on diffusion-restricted reaction that makes high-quality low-input genomic research accessible
… coverage uniformity and markedly reduced chimerism compared with traditional methods. Additionally, we applied single-cell sequencing to identify horizontally transferred genes between the microbes in the gut and revealed human population activities' selective pressure in shaping the …
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Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
… lung cells resulted in robust donor-derived chimerism within the injured host lungs. Transplanted cells formed discrete patches composed of alveolar type I (AQP5⁺, RAGE⁺) and type II (SPC⁺, LAMP3⁺) epithelial cells, endothelial (CD31⁺, ERG⁺), and mesenchymal (PDGFRα⁺) cells. Engraftment was …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… species that exhibits naturally high levels of chimerism. The genome assembly was annotated and is now the National Center for Biotechnology Information (NCBI) reference assembly for the common marmoset. In the second section of this thesis, I generated and analyzed single nucleus RNA sequencing …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… During secondary transplants, NfixΔ/Δ donor chimerism was similar to controls. Also, during steady-state hematopoiesis, we did not observe any overt phenotypes in the NfixΔ/Δ mice. We discovered that overexpressing Nfix ex vivo imparts cells with hypersensitivity to cytokines and resistance …
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Changes in peripheral B cell subsets under immunosuppressive therapy
… transplantation (allo-SCT) patients with stable chimerism often show signs of functional asplenia with appearance of Howell-Jolly bodies in erythrocytes we were interested to study B cell subsets in those patients. After a mean follow-up of 4.7 years 12 clinically stable allo-SCT recipients (five …
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Durchflußzytometrische Analysen zur spenderspezifischen Toleranzinduktion nach kombinierter orthotoper Leber/Dünndarmtransplantation
Trotz der Entwicklung neuer und selektiver Immunsuppressiva, bleibt die Transplantation des Dünndarms auch weiterhin bei einer Fünfjahresüberlebensrate von 35% ein risikoreiches Verfahren, welches nur bei einem kleinen Patientenspektrum derzeit indiziert ist. Die Erkenntnis, daß eine …
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Analyse zu epithelialem Chimärismus an humanen Kolonbiopsien nach allogener hämatopoetischer Zelltransplantation
Innerhalb der letzten Jahre fanden Forscher immer mehr Hinweise darauf, dass KM von Mäusen neben der Blutbildung zusätzlich das Potenzial für die Bildung epithelialer Gewebe besitzt. Auch beim Menschen berichteten vier Studien an Patienten nach allogener HZT über dieses Phänomen (Alison et al 2000, …
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Untersuchung des CFL-Phänotyps ("congenital fused labia" ) in dem Neuweltaffen Common Marmoset (Callithrix jacchus) unter demographischen, physiologischen und zytogenetischen Gesichtspunkten
Die vorliegende Dissertation befasst sich mit dem Phänotyp der verschlossenen Vulva (congentital fused labia; CFL-Phänotyp) in jungen und erwachsenen weiblichen Weißbüschelaffen. Beim CFL-Phänotyp handelt es um einen Verschluss der beiden Labia majora durch ein bindegewebiges Häutchen in …